Sebaceous glands in the cervical mucosa

Abstract Background Hair follicle (HF) development and growth are dependent on epithelial-mesenchymal interactions (EMIs). Dermal papilla (DP) cells are recognized as the key inductive mesenchymal player, but the ideal source of receptive keratinocytes for human HF regeneration is yet to be defined. We herein investigated whether human interfollicular epidermal keratinocytes with stem-like features (EpSlKCs), characterized by a α6bri/CD71dim expression, can replace human hair follicular keratinocytes (HHFKCs) for the recreation of the HF epithelium and respective EMIs. Methods The α6bri/CD71dim cellular fraction was selected from the whole interfollicular keratinocyte population through fluorescence-activated cell sorting and directly compared with follicular keratinocytes in terms of their proliferative capacity and phenotype. The crosstalk with DP cells was studied in an indirect co-culture system, and EpSlKC hair forming capacity tested in a hair reconstitution assay when combined with DP cells. Results EpSlKCs exhibited a phenotypic profile similar to follicular keratinocytes and were capable of increasing DP cell proliferation and, for short co-culture times, the number of alkaline phosphatase-active cells, suggesting an improvement of their inductivity. Moreover, the recreation of immature HFs and sebaceous glands was observed after EpSlKC and DP cell co-grafting in nude mice. Conclusions Our results suggest that EpSlKCs are akin to follicular keratinocytes and can crosstalk with DP cells, contributing to HF morphogenesis in vivo, thus representing an attractive epithelial cell source for hair regeneration strategies.

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Effect of Some Alkaloids, Flavonoids and Triterpenoids, Contents of Japanese-Chinese Traditional Herbal Medicines, on the Lipogenesis of Sebaceous Glands

Skin Pharmacology and Physiology ◽

10.1159/000211087 ◽

1993 ◽

Vol 6 (1) ◽

pp. 56-60 ◽

Cited By ~ 24

Author(s):

Taisuke Seki ◽

Masaaki Morohashi

Keyword(s):

Herbal Medicines ◽

Sebaceous Glands

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ACNE AND THE SEBACEOUS GLANDS

International Journal of Dermatology ◽

10.1111/j.1365-4362.1976.tb01803.x ◽

1976 ◽

Vol 15 (5) ◽

pp. 337-343 ◽

Cited By ~ 6

Author(s):

W. J. CUNLIFFE ◽

S. G. TAN

Keyword(s):

Sebaceous Glands

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THE ACTION OF AN ANTI-ANDROGENIC STEROID, 17α-METHYL-B-NORTESTOSTERONE, ON SEBUM SECRETION IN RATS TREATED WITH TESTOSTERONE

Journal of Endocrinology ◽

10.1677/joe.0.0380181 ◽

1967 ◽

Vol 38 (2) ◽

pp. 181-185 ◽

Cited By ~ 31

Author(s):

F. J. EBLING

Keyword(s):

Female Rats ◽

Sebaceous Glands ◽

Androgenic Steroid ◽

Sebum Production ◽

Sebum Secretion ◽

Do So

SUMMARY An anti-androgenic steroid, 17α-methyl-B-nortestosterone was shown to reduce sebum production in spayed female rats treated simultaneously with testosterone. The sebum production was assessed by measuring the increase in the amount of ether-extractable hair fat over a period of 8 days immediately after washing the rats. Testosterone increased the secretion of sebum mainly by stimulating mitosis in the sebaceous glands and it was shown that the anti-androgenic steroid acted at this site, i.e. by suppressing mitosis. These effects were in contrast to the action of oestradiol which also depressed sebaceous activity, but appeared to do so by interfering with synthesis in the sebaceous cells.

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On the Presence of a Ciliated Columnar Epithelial Cell Type within the Bovine Cervical Mucosa

Journal of Animal Science ◽

10.2527/jas1973.365936x ◽

1973 ◽

Vol 36 (5) ◽

pp. 936-940 ◽

Cited By ~ 4

Author(s):

R. J. Wordinger ◽

J. B. Ramsey ◽

J. F. Dickey ◽

J. R. Hill

Keyword(s):

Epithelial Cell ◽

Cell Type ◽

Epithelial Cell Type ◽

Columnar Epithelial Cell ◽

Cervical Mucosa

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A histological examination of the holding sacs and glandular scent organs of some bat species (Emballonuridae, Hipposideridae, Phyllostomidae, Vespertilionidae, and Molossidae)

Canadian Journal of Zoology ◽

10.1139/z99-248 ◽

2000 ◽

Vol 78 (4) ◽

pp. 613-623 ◽

Cited By ~ 29

Author(s):

William MR Scully ◽

M B Fenton ◽

A SM Saleuddin

Keyword(s):

Electron Microscope ◽

Sexual Dimorphism ◽

Sebaceous Glands ◽

Microscope Examination ◽

Scent Gland ◽

Light Microscope Level ◽

Histological Techniques ◽

Saccopteryx Bilineata ◽

The Face ◽

Scanning Electron

Using histological techniques at the light-microscope level, we examined and compared structure and sexual dimorphism of the wing sacs and integumentary glandular scent organs of 11 species of microchiropteran bats. The antebrachial wing sacs of the Neotropical emballonurids Peropteryx macrotis, Saccopteryx bilineata, and Saccopteryx leptura differed in size and location but lacked sudoriferous and sebaceous glands, confirming that they were holding sacs rather than glandular scent organs. Glandular scent organs from 11 species consisted of sebaceous and (or) sudoriferous glands in emballonurids (P. macrotis, S. bilineata, S. leptura, Taphozous melanopogon, Taphozous nudiventris), hipposiderids (Hipposiderous fulvus, Hipposiderous ater), the phyllostomid Sturnira lilium, the vespertilionid Rhogeessa anaeus, and molossids (Molossus ater and Molossus sinaloe). Glandular scent organs were located on the face (H. fulvus, H. ater), gular region (S. bilineata, P. macrotis, T. melanopogon, M. ater, M. sinaloe), chest (T. nudiventris), shoulder (S. lilium), or ears (R. anaeus). Glandular scent organs showed greater similarities within than between families, and typically were rudimentary or lacking in females. Scanning electron microscope examination revealed that the hairs associated with glandular areas of male T. melanopogon were larger and had a different cuticular-scale pattern than body hairs. These were osmetrichia, hairs specialized for holding and dispersing glandular products. In S. lilium, hairs associated with the shoulder scent-gland area were larger than body hairs but similar in cuticular-scale pattern.

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