THE ACTION OF AN ANTI-ANDROGENIC STEROID, 17α-METHYL-B-NORTESTOSTERONE, ON SEBUM SECRETION IN RATS TREATED WITH TESTOSTERONE

1967 ◽  
Vol 38 (2) ◽  
pp. 181-185 ◽  
Author(s):  
F. J. EBLING
Keyword(s):  
Female Rats ◽  
Sebaceous Glands ◽  
Androgenic Steroid ◽  
Sebum Production ◽  
Sebum Secretion ◽  
Do So

SUMMARY An anti-androgenic steroid, 17α-methyl-B-nortestosterone was shown to reduce sebum production in spayed female rats treated simultaneously with testosterone. The sebum production was assessed by measuring the increase in the amount of ether-extractable hair fat over a period of 8 days immediately after washing the rats. Testosterone increased the secretion of sebum mainly by stimulating mitosis in the sebaceous glands and it was shown that the anti-androgenic steroid acted at this site, i.e. by suppressing mitosis. These effects were in contrast to the action of oestradiol which also depressed sebaceous activity, but appeared to do so by interfering with synthesis in the sebaceous cells.

EFFECT OF SEX AND AGE AT GONADECTOMY ON THE SEBACEOUS RESPONSE TO PROGESTERONE

1977 ◽  
Vol 73 (1) ◽  
pp. 67-70 ◽  
Author(s):  
SAM SHUSTER ◽  
WENDY M. HINKS ◽  
A. J. THODY
Keyword(s):  
Adult Female ◽  
Adult Male ◽  
Female Rats ◽  
Male Rats ◽  
Adult Males ◽  
Adult Rat ◽  
Sebum Production ◽  
Males And Females ◽  
Sebum Secretion

SUMMARY The effect of progesterone on the rate of sebum secretion was examined in intact and gonadectomized rats. In intact, adult, male rats, progesterone administered for 3 weeks decreased sebum secretion; after castration of adult males, progesterone increased sebum secretion and an even greater response occurred in males castrated at 21 days of age. In intact, adult, female rats progesterone slightly increased sebum production. As in the male, the response was affected by the time of gonadectomy, a greater response occurring after spaying at 21 days compared with 10 weeks of age. Thus, the response to progesterone in the adult rat differs in intact males and females and is affected by changes in the endocrine environment induced by gonadectomy, especially near the time of puberty.

ROLE OF THE GONADS IN THE REGULATION OF SEBACEOUS GLANDS IN RATS: COMPARISON OF THE EFFECTS OF CASTRATION AT AND AFTER BIRTH

1980 ◽  
Vol 85 (2) ◽  
pp. 261-265 ◽  
Author(s):  
YEE CHU TOH
Keyword(s):  
Skin Surface ◽  
Female Rats ◽  
Sprague Dawley ◽  
Sebaceous Glands ◽  
Male And Female Rats ◽  
Sprague Dawley Rats ◽  
Sequential Event ◽  
Sebum Production ◽  
Skin Surface Lipids

Sprague–Dawley rats were castrated either within 24 h of birth or at 4 weeks of age. Control animals were sham operated. Intact female rats were also included for comparison. Sebum production was assessed at 80 days of age by measuring the amount of skin-surface lipids that could be extracted with acetone and which had been produced during 2 days. The removal of the testes at birth reduced the activity of the sebaceous glands to a level more nearly approaching that seen in the female rats whereas castration at 4 weeks of age only partially decreased the rate of sebum secretion so that it was intermediate between the male and female rats. The weights of the pituitary gland, thyroid and adrenal glands increased after castration but there were no differences between rats castrated at birth and those castrated at 4 weeks of age except in the weight of the thyroid gland. It would appear that the role of the testes in the control of the activity of the sebaceous glands is a sequential event which has already started at birth.

INCREASED SEBUM SECRETION IN ADULT FEMALE RATS AFTER NEONATAL TREATMENT WITH TESTOSTERONE PROPIONATE

1971 ◽  
Vol 49 (4) ◽  
pp. 677-681 ◽  
Author(s):  
A. J. THODY ◽  
S. SHUSTER
Keyword(s):  
Adult Female ◽  
Testosterone Propionate ◽  
Female Rats ◽  
Sebaceous Glands ◽  
Adult Rats ◽  
Gland Weight ◽  
Androgen Treatment ◽  
Sebum Secretion ◽  
Normal Inhibition ◽  
Normal Adults

SUMMARY Testosterone propionate (TP) was administered to female rats at 3 and 6 days of age. When adult the sebum secretion rate of these rats was significantly increased, although the response to TP was normal. Neonatal androgen treatment had no effect on the preputial gland weight of adult female rats. On the other hand ovarian weight was reduced. After ovariectomy of normal adult rats there was an increase in sebum secretion to a level comparable to that found in adult rats given TP as neonates. By contrast there was no change in sebum secretion after ovariectomy of adult rats given TP as neonates and the rate of sebum secretion in these rats was comparable to that in ovariectomized normal adults. It is suggested that after neonatal androgen treatment the normal inhibition of the sebaceous glands by the ovaries was abolished and consequently the rate of secretion was increased. Thus the endocrine state in early life may have a lasting effect on sebaceous gland activity in the adult.

THE EFFECTS OF THYROTROPHIC HORMONE AND OF THYROXINE ON THE RESPONSE OF THE SEBACEOUS GLANDS OF THE RAT TO TESTOSTERONE

1970 ◽  
Vol 48 (1) ◽  
pp. 83-90 ◽  
Author(s):  
F. J. EBLING ◽  
ERIKA EBLING ◽  
J. SKINNER
Keyword(s):  
Thyroid Gland ◽  
Male Rats ◽  
Sebaceous Glands ◽  
Thyrotrophic Hormone ◽  
Sebum Production ◽  
Sebum Secretion ◽  
Stimulation Of

SUMMARY Treatment with thyrotrophic hormone (TSH) significantly enhanced the action of testosterone in increasing sebum secretion in both castrated and hypophysectomized—castrated male rats. The dose of TSH, equivalent to about 0·1 i.u./24 h for 24 days, was insufficient to increase thyroid weight, even though this was only half of normal in the hypophysectomized—castrated rats. Treatment with thyroxine (T4) significantly added to the action of testosterone in increasing sebum production in castrated rats, but the effect was accompanied by a decreased incidence of mitoses in the sebaceous glands. Treatment with propylthiouracil did not by itself affect sebaceous activity in castrated rats, nor did it inhibit the action of testosterone. Sebum secretion in castrated animals treated with propylthiouracil and testosterone was significantly higher than in those treated with testosterone alone. In view of the evidence that TSH and T4, although similar in their effects on sebum secretion, appeared to act in opposite ways on the incidence of sebaceous mitoses, and that the response of the sebaceous glands to testosterone was increased rather than inhibited by treatment of the rats with propylthiouracil, it is concluded that the action of TSH in enhancing the sebaceous response is more likely to be direct than indirect by stimulation of the thyroid gland.

THE RESPONSE OF THE SEBACEOUS GLANDS OF THE HYPOPHYSECTOMIZED—CASTRATED MALE RAT TO 5α-DIHYDROTESTOSTERONE, ANDROSTENEDIONE, DEHYDROEPIANDROSTERONE AND ANDROSTERONE

1971 ◽  
Vol 51 (1) ◽  
pp. 181-190 ◽  
Author(s):  
F. J. EBLING ◽  
ERIKA EBLING ◽  
VIRGINIA McCAFFERY ◽  
J. SKINNER
Keyword(s):  
Active Metabolite ◽  
Male Rat ◽  
Sebaceous Glands ◽  
Sebum Production ◽  
Do So

SUMMARY 5α-Dihydrotestosterone and androstenedione (0·2 mg/24 h for 24 days), but not testosterone, significantly increased sebum production in hypophysectomized—castrated rats. Dehydroepiandrosterone and androsterone, even in doses ten times greater, could not be shown to do so, though all the steroids increased the incidence of mitoses in the sebaceous glands. In rats with intact pituitaries, however, the greatest effect on sebaceous secretion was produced by testosterone. A significant increase was also produced by 5α-dihydrotestosterone; androstenedione was only effective at ten times the dose, and androsterone was without significant effect. Dehydroepiandrosterone was not tested. A possible interpretation of the results is that within the sebaceous glands, either the release of testosterone from its conjugates or its conversion to an active metabolite is under pituitary control. The results also support the view that there are at least two distinct points of action of steroids on the sebaceous glands, namely mitosis and intracellular synthesis of sebum.

Serca2a and Na+/Ca2+ exchanger are involved in left ventricular function following cardiac remodelling of female rats treated with anabolic androgenic steroid

2016 ◽  
Vol 301 ◽  
pp. 22-30 ◽  
Author(s):  
Andrews Marques do Nascimento ◽  
Ewelyne Miranda de Lima ◽  
Girlandia Alexandre Brasil ◽  
Izabela Facco Caliman ◽  
Josiane Fernandes da Silva ◽  
...  
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Female Rats ◽  
Cardiac Remodelling ◽  
Anabolic Androgenic Steroid ◽  
Androgenic Steroid

EFFECT OF NEONATAL ADMINISTRATION OF THYROXINE ON THE RATE OF SEBUM PRODUCTION IN RATS

1979 ◽  
Vol 83 (2) ◽  
pp. 199-203 ◽  
Author(s):  
YEE CHU TOH
Keyword(s):  
Normal Activity ◽  
Skin Surface ◽  
Postnatal Period ◽  
Female Rats ◽  
Sprague Dawley ◽  
Male And Female Rats ◽  
Sprague Dawley Rats ◽  
Sebum Production ◽  
Skin Surface Lipids ◽  
Neonatal Administration

Newborn Sprague–Dawley rats of both sexes were treated with 28 μg thyroxine (T4) daily for the first week of life. At the age of 80 days, the secretion rate of sebum was measured from the amount of skin-surface lipids extractable by acetone and which had been produced during 2 days. Treatment with such excess amounts of T4 during the early postnatal period significantly reduced the production of sebum in both male and female rats when compared with control rats and with rats deprived of food early in life. The thyroid, the pituitary gland, the testes and the seminal vesicles were significantly smaller but the weights of the ovaries and uteri remained relatively unaffected. There was a similar ratio of sex difference in the rate of sebum secretion irrespective of treatment. It is suggested that a reduction of sebaceous response in rats made thyrotoxic with large doses of T4 early in life was probably due to a decreased secretion of thyroid hormone which is required to maintain normal activity of the sebaceous glands.

scholarly journals Role of Androgen on Physiological Function of Pilosebaceous Unit

2021 ◽  
Vol 5 (3) ◽  
pp. 573-579
Author(s):  
Inda Astri Aryani ◽  
Cayadi Sidarta Antonius ◽  
Suroso Adi Nugroho ◽  
Nopriyati
Keyword(s):  
Hair Growth ◽  
Androgen Receptors ◽  
Physiological Function ◽  
Steroid Hormone ◽  
Hair Follicles ◽  
Sebaceous Glands ◽  
Pilosebaceous Unit ◽  
Sebum Production ◽  
Dermal Papillae

The pilosebaceous unit is a sebaceous gland with hair follicles. One of the hormones that affects the pilosebaceous unit is androgen, a steroid hormone that plays an important role in the expression of the phenotype of men and women. Androgen consist of testosterone and dihydrotestosterone which are activated by androgen receptors. Androgen in the pilosebaceous unit affect sebum production and hair growth. Androgen receptors in the sebaceous glands are found on sebocytes and in hair follicles in the dermal papillae of hair follicles

THE EFFECT OF HYPOPHYSECTOMY ON THE RESPONSE OF THE SEBACEOUS GLAND TO TESTOSTERONE PROPIONATE

1971 ◽  
Vol 49 (2) ◽  
pp. 329-333 ◽  
Author(s):  
A. J. THODY ◽  
S. SHUSTER
Keyword(s):  
Sebaceous Gland ◽  
Testosterone Propionate ◽  
Preputial Gland ◽  
Sebaceous Glands ◽  
Gland Weight ◽  
Actual Increase ◽  
Small Doses ◽  
Sebum Secretion ◽  
Higher Doses

SUMMARY The effect of varying doses of testosterone propionate (TP) on the sebum secretion and preputial gland weight of castrated and hypophysectomized—castrated rats was studied. The changes in preputial gland weight closely paralleled those of sebum secretion. Small doses of TP (0·05 mg) stimulated sebum secretion in hypophysectomized-castrated rats, but not in the castrated rats. Higher doses of TP increased sebum secretion in both the hypophysectomized—castrates and the castrated rats. While 0·5 mg TP completely restored sebum secretion to normal levels in castrated rats but not in the hypophysectomized—castrated rats, the actual increase in sebum secretion produced by this dose of TP was similar in both groups. It is concluded that at physiological doses the action of TP on the sebaceous glands is independent of the pituitary. However, the presence of the pituitary is required for normal sebaceous gland activity.

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