scholarly journals Pivotal Role of Interleukin-12 and Interferon-γ Axis in Controlling Tissue Parasitism and Inflammation in the Heart and Central Nervous System during Trypanosoma cruzi Infection

2001 ◽  
Vol 159 (5) ◽  
pp. 1723-1733 ◽  
Author(s):  
Vladimir Michailowsky ◽  
Neide M. Silva ◽  
Carolina D. Rocha ◽  
Leda Q. Vieira ◽  
Joseli Lannes-Vieira ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Trypanosoma Cruzi ◽  
Interferon Γ ◽  
Pivotal Role ◽  
Interleukin 12 ◽  
Cruzi Infection

scholarly journals Role of endothelin receptors in the control of central nervous system parasitism in Trypanosoma cruzi infection in rats

2010 ◽  
Vol 220 (1-2) ◽  
pp. 64-68 ◽  
Author(s):  
Milene A. Rachid ◽  
Antônio L. Teixeira ◽  
Lucíola S. Barcelos ◽  
Conceição R.S. Machado ◽  
Egler Chiari ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Trypanosoma Cruzi ◽  
Endothelin Receptors ◽  
Cruzi Infection

scholarly journals The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system

2019 ◽  
Vol 5 (4) ◽  
pp. a004143 ◽  
Author(s):  
Derek Wong ◽  
Yaoqing Shen ◽  
Adrian B. Levine ◽  
Erin Pleasance ◽  
Martin Jones ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pivotal Role ◽  
Recurrent Tumors ◽  
The Central Nervous System

scholarly journals The Role of Vitamin D in Neurodegeneration and Other Pathological Processes of the Central Nervous System

2021 ◽  
Author(s):  
Carl Nikolaus Homann
Keyword(s):  
Central Nervous System ◽  
Vitamin D ◽  
Nervous System ◽  
Human Body ◽  
Serum Levels ◽  
Nerve Cells ◽  
Pivotal Role ◽  
The Central Nervous System ◽  
Measured Response

The nervous system is the most complex organ in the human body, and it is the most essential. However nerve cells are particularly precious as, only like muscle cells, once formed, they do not replicate. This means that neural injuries cannot easily be replaced or repaired. Vitamin D seems to play a pivotal role in protecting these vulnerable and most important structures, but exactly how and to what extend is still subject to debate. Systematically reviewing the vast body of research on the influence of Vitamin D in various neuropathological processes, we found that Vitamin D particularly plays a mitigating role in the development of chronic neurodegeneration and the measured response to acutely acquired traumatic and non-traumatic nerve cells incidents. Adequate serum levels of Vitamin D before the initiation of these processes is increasingly viewed as being neuroprotective. However, comprehensive data on using it as a treatment during the ongoing process or after the injury to neurons is completed are much more ambiguous. A recommendation for testing and supplementation of insufficiencies seems to be well-founded.

Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism

2008 ◽  
Vol 294 (5) ◽  
pp. E810-E816 ◽  
Author(s):  
Eva Rother ◽  
A. Christine Könner ◽  
Jens C. Brüning
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Glucose Metabolism ◽  
Molecular Mechanisms ◽  
Pivotal Role ◽  
Energy Regulation ◽  
Peripheral Organs ◽  
Nutrient Signaling ◽  
The Central Nervous System

As obesity, diabetes, and associated comorbidities are on a constant rise, large efforts have been put into better understanding the cellular and molecular mechanisms by which nutrients and metabolic signals influence central and peripheral energy regulation. For decades, peripheral organs as a source and a target of such cues have been the focus of study. Their ability to integrate metabolic signals is essential for balanced energy and glucose metabolism. Only recently has the pivotal role of the central nervous system in the control of fuel partitioning been recognized. The rapidly expanding knowledge on the elucidation of molecular mechanisms and neuronal circuits involved is the focus of this review.

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