CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation

Brain Research ◽

10.1016/s0006-8993(00)03293-5 ◽

2001 ◽

Vol 893 (1-2) ◽

pp. 95-103 ◽

Author(s):

Lynn Pulliam ◽

Ian Irwin ◽

Leonard Kusdra ◽

Hans Rempel ◽

William D. Flitter ◽

...

Keyword(s):

Erk Activation ◽

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AIDS dementia complex (ADC) and HIV infection of the CNS: Pathophysiologically-based approach to treatment and evaluation

Electroencephalography and Clinical Neurophysiology ◽

10.1016/s0013-4694(97)88029-0 ◽

1997 ◽

Vol 103 (1) ◽

pp. 27

Author(s):

R Price

Keyword(s):

Hiv Infection ◽

Aids Dementia Complex ◽

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Cortical actin organization is required for internalization of bombesin/GRP and EGF receptors, and ERK activation in Swiss 3T3 cells

Gastroenterology ◽

10.1016/s0016-5085(01)81542-0 ◽

2001 ◽

Vol 120 (5) ◽

pp. A310-A311

Author(s):

J LUNN ◽

H WONG ◽

E ROZENGURT ◽

J WALSH

Keyword(s):

Egf Receptors ◽

3T3 Cells ◽

Cortical Actin ◽

Erk Activation ◽

Actin Organization ◽

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MEK/ERK activation is necessary for neuronal death resulted from oxidative stress

Neuroscience Research ◽

10.1016/s0168-0102(00)81257-2 ◽

2000 ◽

Vol 38 ◽

pp. S68

Author(s):

H Kikuchi

Keyword(s):

Oxidative Stress ◽

Neuronal Death ◽

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Faculty Opinions recommendation of The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1012273.185025 ◽

2003 ◽

Author(s):

Deborah Morrison

Keyword(s):

G Protein ◽

G Protein Coupled Receptor ◽

Erk Activation ◽

Functional Consequence ◽

The Stability ◽

G Protein Coupled ◽

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Faculty Opinions recommendation of Phrenic long-term facilitation after acute intermittent hypoxia requires spinal ERK activation but not TrkB synthesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718021180.793478906 ◽

2013 ◽

Author(s):

Frank L Powell

Keyword(s):

Intermittent Hypoxia ◽

Erk Activation ◽

Long Term Facilitation

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Faculty Opinions recommendation of Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718095226.793483020 ◽

2013 ◽

Author(s):

Ralf Jockers

Keyword(s):

Endocrine Cells ◽

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Faculty Opinions recommendation of Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718149026.793488683 ◽

2013 ◽

Author(s):

Akira Kikuchi

Keyword(s):

Cell Density ◽

Erk Activation ◽

Density Dependent ◽

Cell Propagation

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Faculty Opinions recommendation of Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell Survival in Human Endometriosis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725509191.793508571 ◽

2015 ◽

Author(s):

Kaei Nasu

Keyword(s):

Cell Survival ◽

Erk Activation ◽

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ERK activation increases nitroprusside induced apoptosis in human melanoma cells irrespective of p53 status: Role of superoxide dismutases

Cancer Biology & Therapy ◽

10.4161/cbt.8.12.8561 ◽

2009 ◽

Vol 8 (12) ◽

pp. 1173-1182 ◽

Author(s):

Luis Alberto Gomez–Sarosi ◽

Mary Strasberg–Rieber ◽

Manuel Rieber

Keyword(s):

Melanoma Cells ◽

Human Melanoma ◽

Superoxide Dismutases ◽

Erk Activation ◽

Human Melanoma Cells ◽

Induced Apoptosis

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Actin Depolymerization Transduces the Strength of B-Cell Receptor Stimulation

Molecular Biology of the Cell ◽

10.1091/mbc.e04-10-0881 ◽

2005 ◽

Vol 16 (5) ◽

pp. 2275-2284 ◽

Author(s):

Shengli Hao ◽

Avery August

Keyword(s):

B Cell ◽

Cell Activation ◽

Cell Receptor ◽

Dependent Manner ◽

B Cell Activation ◽

Erk Activation ◽

Actin Depolymerization ◽

Transcription Factor Activation ◽

Raft Clustering

Polymerization of the actin cytoskeleton has been found to be essential for B-cell activation. We show here, however, that stimulation of BCR induces a rapid global actin depolymerization in a BCR signal strength-dependent manner, followed by polarized actin repolymerization. Depolymerization of actin enhances and blocking actin depolymerization inhibits BCR signaling, leading to altered BCR and lipid raft clustering, ERK activation, and transcription factor activation. Furthermore actin depolymerization by itself induces altered lipid raft clustering and ERK activation, suggesting that F-actin may play a role in separating lipid rafts and in setting the threshold for cellular activation.

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