Quantitative autoradiographic mapping of μ-, δ- and κ-opioid receptors in knockout mice lacking the μ-opioid receptor gene

1997 ◽  
Vol 778 (1) ◽  
pp. 73-88 ◽  
Author(s):  
Ian Kitchen ◽  
Susan J Slowe ◽  
Hans W.D Matthes ◽  
Brigitte Kieffer
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Knockout Mice ◽  
Receptor Gene ◽  
Μ Opioid Receptor

G-protein coupling of δ-opioid receptors in brains of μ-opioid receptor knockout mice

2003 ◽  
Vol 466 (1-2) ◽  
pp. 91-98 ◽  
Author(s):  
Sarah M. Oakley ◽  
Geza Toth ◽  
Anna Borsodi ◽  
Brigitte L. Kieffer ◽  
Ian Kitchen
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Opioid Receptors ◽  
Knockout Mice ◽  
G Protein Coupling ◽  
Protein Coupling ◽  
Μ Opioid Receptor

Quantitative autoradiographic mapping of opioid receptors in the brain of δ-opioid receptor gene knockout mice

2002 ◽  
Vol 945 (1) ◽  
pp. 9-19 ◽  
Author(s):  
Robin J Goody ◽  
Sarah M Oakley ◽  
Dominique Filliol ◽  
Brigitte L Kieffer ◽  
Ian Kitchen
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Knockout Mice ◽  
Gene Knockout ◽  
Receptor Gene ◽  
Gene Knockout Mice ◽  
Δ Opioid Receptor ◽  
The Brain

Exploring μ-Opioid Receptor Splice Variants as a Specific Molecular Target for New Analgesics

2020 ◽  
Vol 20 (31) ◽  
pp. 2866-2877
Author(s):  
Hirokazu Mizoguchi ◽  
Hideaki Fujii
Keyword(s):  
Side Effects ◽  
Opioid Receptor ◽  
Opioid Receptors ◽  
Analgesic Effect ◽  
Splice Variants ◽  
Receptor Gene ◽  
Molecular Target ◽  
Μ Opioid Receptor ◽  
Dependence Liability ◽  
Μ Opioid Receptors

Since a μ-opioid receptor gene containing multiple exons has been identified, the variety of splice variants for μ-opioid receptors have been reported in various species. Amidino-TAPA and IBNtxA have been discovered as new analgesics with different pharmacological profiles from morphine. These new analgesics show a very potent analgesic effect but do not have dependence liability. Interestingly, these analgesics show the selectivity to the morphine-insensitive μ-opioid receptor splice variants. The splice variants, sensitive to these new analgesics but insensitive to morphine, may be a better molecular target to develop the analgesics without side effects.

Sign in / Sign up

Export Citation Format

Share Document