Nerve growth factor stimulates MAPK via the low affinity receptor p75LNTR

FEBS Letters ◽  
1999 ◽  
Vol 463 (3) ◽  
pp. 231-234 ◽  
Author(s):  
Kathrin Susen ◽  
Rolf Heumann ◽  
Andrea Blöchl
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Affinity Receptor

Estrogen-induced proliferation of urothelial cells is modulated by nerve growth factor

2002 ◽  
Vol 282 (6) ◽  
pp. F1075-F1083 ◽  
Author(s):  
Jian Teng ◽  
Zun-Yi Wang ◽  
Dale E. Bjorling
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Primary Cultures ◽  
Cell Types ◽  
Urothelial Cells ◽  
Nerve Growth ◽  
High Affinity Receptor ◽  
17Β Estradiol ◽  
Affinity Receptor ◽  
Estrogen Antagonist

Both nerve growth factor (NGF) and estrogen have been shown to stimulate proliferation of various cell types. Human urothelial cells (HUC) express the α- and β-subtypes of the estrogen receptor (ERαand ERβ) as well as tyrosine kinase A (trkA), the high-affinity receptor for NGF. We investigated interactions between estrogen and NGF relative to cell proliferation using primary cultures of HUC. 17β-estradiol (E2) stimulated NGF synthesis by HUC, and E2 (50 nM), the ERαagonist 16α-iodo-17β-estradiol (10 nM), or the ERβagonist genistein (50 nM) each stimulated HUC proliferation, an effect that was abolished by the estrogen antagonist ICI-182,780 (100 nM). NGF (1–100 ng/ml) stimulated HUC proliferation, and this was abolished by NGF antiserum (0.1 μl/ml) or the trkA antagonist K252a (100 nM). HUC proliferation stimulated by E2 was also abolished by NGF antiserum or K252a. Finally, we observed that treatment of HUC with NGF (50 ng/ml) or E2 (50 nM) stimulated trkA phosphorylation, and this was abolished by K252a (100 nM) or NGF antiserum (0.1 μl/ml). These data indicate that the effects of ER activation on HUC proliferation at least partly involve activation of trkA by NGF.

scholarly journals Autocrine Nerve Growth Factor Protects Human Keratinocytes from Apoptosis Through its High Affinity Receptor (TRK): A Role for BCL-2

1997 ◽  
Vol 109 (6) ◽  
pp. 757-764 ◽  
Author(s):  
Carlo Pincelli ◽  
Anne R. Haake ◽  
Luisa Benassi ◽  
Emanuela Grassilli ◽  
Cristina Magnoni ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Human Keratinocytes ◽  
Nerve Growth ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Trk A

scholarly journals Nerve Growth Factor and Its High-Affinity Receptor in Chronic Pancreatitis

1999 ◽  
Vol 230 (5) ◽  
pp. 615 ◽  
Author(s):  
Helmut Friess ◽  
Zhao-Wen Zhu ◽  
Fabio F. di Mola ◽  
Christoph Kulli ◽  
Hans U. Graber ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor

Effects of perinatal hypo- and hyperthyroidism on the levels of nerve growth factor and its low-affinity receptor in cerebellum

1993 ◽  
Vol 72 (2) ◽  
pp. 237-244 ◽  
Author(s):  
B.C. Figueiredo ◽  
U. Otten ◽  
S. Strauss ◽  
B. Volk ◽  
D. Maysinger
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Affinity Receptor
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