Endometrial effects of long-term low-dose administration of RU486**Supported by San Diego Reproductive Medicine Educational and Research Foundation, San Diego, California and the Andrew W. Mellon Foundation, New York, New York.††Presented in part at the 48th Annual Meeting of Society of Gynecologic Investigation, Toronto, Ontario, Canada, March 31 to April 3, 1993.

1995 ◽  
Vol 63 (4) ◽  
pp. 761-766 ◽  
Author(s):  
Ana Alvarez Murphy ◽  
L. Michael Kettel ◽  
Arlene J. Morales ◽  
Veronica Roberts ◽  
Tim Parmley ◽  
...  
Keyword(s):  
New York ◽  
Annual Meeting ◽  
Reproductive Medicine ◽  
San Diego ◽  
Low Dose ◽  
Dose Administration

scholarly journals Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice

2020 ◽  
Vol 17 (5) ◽  
pp. 1579
Author(s):  
Svenja Koslowski ◽  
Camille Latapy ◽  
Pierrïck Auvray ◽  
Marc Blondel ◽  
Laurent Meijer
Keyword(s):  
Gaba Receptors ◽  
Memory Impairment ◽  
Low Dose ◽  
Antagonistic Activity ◽  
Aminobutyric Acid ◽  
Environmental Toxicants ◽  
Main Metabolite ◽  
Dose Administration ◽  
Cognitive Deficiencies

Fipronil is an insecticide widely used for veterinary and agricultural purposes. While its insecticidal properties mostly rely on its high affinity antagonistic activity on insect γ aminobutyric acid (GABA) receptors, fipronil and its main metabolite fipronil sulfone nevertheless display non-negligible affinity for mammalian GABAA receptor. As several environmental toxicants have been shown to raise the risk of developing various neurodegenerative disorders, the aim of this study was to evaluate whether long-term low dose administration of fipronil could lead to cognitive deficiencies. Our results indicate that long-term fipronil treatment leads to behavioral perturbations in mice, indicating an accumulative effect of sustained exposure to low dose of fipronil. Although no memory impairment was observed during the course of our study, we noticed a significant hyperlocomotion behavior after 43 weeks of weekly fipronil administration, which is consistent with its direct effect on the GABAergic system.

Effect of Long-Term and Low-Dose Administration of Erythromycin on Proliferation of T Lymphocytes

2008 ◽  
Vol 20 (5) ◽  
pp. 604-608 ◽  
Author(s):  
S. Harita ◽  
S. Kuyama ◽  
T. Okada ◽  
Y. Tanizaki
Keyword(s):  
T Lymphocytes ◽  
Low Dose ◽  
Dose Administration

Long-Term Low-Dose Administration of Erythromycin to Patients with Diffuse Panbronchiolitis

Respiration ◽  
1991 ◽  
Vol 58 (3-4) ◽  
pp. 145-149 ◽  
Author(s):  
Hideaki Nagai ◽  
Harumi Shishido ◽  
Ryozo Yoneda ◽  
Eriko Yamaguchi ◽  
Atsuhisa Tamura ◽  
...  
Keyword(s):  
Low Dose ◽  
Dose Administration ◽  
Diffuse Panbronchiolitis

Safety and Effectiveness of Low-Dose Clozapine in Psychogeriatric Patients: A Preliminary Study

1992 ◽  
Vol 4 (2) ◽  
pp. 187-195 ◽  
Author(s):  
A. F. Oberholzer ◽  
C. Hendriksen ◽  
A. U. Monsch ◽  
B. Heierli ◽  
H. B. Stähelin
Keyword(s):  
Side Effects ◽  
Low Dose ◽  
Term Treatment ◽  
Dose Administration ◽  
Group Of Seven ◽  
Long Term Treatment ◽  
Short And Long Term ◽  
Treatment Tolerance ◽  
Psychogeriatric Patients

The short- and long-term treatment tolerance of low-dose clozapine was retrospectively investigated in 18 psychogeriatric patients. Discontinued use of the drug because of side effects or inefficiency was required for only four patients. In the long-term treatment group leukopenia was not observed, and disturbances of liver function appeared to be very infrequent. A second group of seven severely demented psychogeriatric inpatients who were currently being treated with low-dose clozapine underwent a withdrawal study in order to evaluate the therapeutic efficacy of the drug, measured by the NOSIE and the SCAG scales. The results indicate that for patients such as these, with paranoid or socially disturbing behavior who also tend to develop severe neurological side effects with classical neuroleptics, a low-dose administration of clozapine is an acceptable alternative treatment.

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