Interruption of endometrial maturation without hormonal changes by an antiprogesterone during the first half of luteal phase of the menstrual cycle: a contraceptive potential**Supported by the San Diego Reproductive Medicine Research and Educational Foundation, San Diego, California and conducted, in part, by the Mellon Foundation, New York, New York.

1992 ◽  
Vol 58 (2) ◽  
pp. 338-343 ◽  
Author(s):  
Kerry E. Greene ◽  
L. Michael Kettel ◽  
Samuel S.C. Yen
Keyword(s):  
New York ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Reproductive Medicine ◽  
San Diego ◽  
Hormonal Changes ◽  
Medicine Research ◽  
Educational Foundation

scholarly journals The levels of adipokines in relation to hormonal changes during the menstrual cycle in young, normal-weight women

2017 ◽  
Vol 6 (8) ◽  
pp. 892-900 ◽  
Author(s):  
Katarzyna Wyskida ◽  
Grzegorz Franik ◽  
Tomasz Wikarek ◽  
Aleksander Owczarek ◽  
Alham Delroba ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Multivariate Regression ◽  
Normal Weight ◽  
Total Testosterone ◽  
Hormonal Changes ◽  
Regression Analyses ◽  
Anthropometric Parameters ◽  
Tnf Α ◽  
Plasma Leptin

Context The aim of this study was to assess the plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 levels in relation to hormonal changes during the menstrual cycle in young, healthy, normal-weight women. Methods The study involved 52 young, healthy, normal-weight women. Anthropometric parameters, body composition and levels of plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 in addition to serum FSH, LH, estradiol, progesterone, 17-OH progesterone, androgens, SHBG and insulin concentrations were measured during a morning in fasting state three times: between days 2–4, days 12–14 and days 24–26 of the menstrual cycle. Results Plasma adiponectin, omentin-1, resistin and visfatin/NAMPT, apelin, TNF-α, IL-6 and RBP4 concentrations were stable during the menstrual cycle, while leptin and vaspin levels were significantly higher in both the midcycle and the luteal phases than those in the follicular phase. Multivariate regression analyses revealed that changes in leptin and vaspin levels between the follicular and the luteal phase are strongly related to changes in total testosterone levels. Conclusions Our results revealed stable levels of adipokines during the phases of the physiological menstrual cycle, except for leptin and vaspin, which showed increased levels in both the midcycle and the luteal phases. This effect was significantly associated with changes in the secretion of testosterone, 17-OH progesterone and insulin in the luteal phase.

Hubungan Antara Status Gizi Dan Tingkat Stres Dengan Kejadian Pre-Menstrual Syndrome Pada Remaja Putri Di Pondok Pesantren Lirboyo Kota Kediri Tahun 2016

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Miftakhul Mualimah ◽  
Ana Wildani
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Simple Random Sampling ◽  
Physical Symptoms ◽  
Nutrition Status ◽  
P Value ◽  
Hormonal Changes ◽  
Cross Sectional ◽  
Stress Levels ◽  
Current Cycle

ABSTRAK Pre-Menstrual Syndrome adalah kumpulan gejala fisik, psikologis dan emosi yang terkait dengan siklus menstruasi wanita dan secara konsisten terjadi selama fase luteal dari siklus menstruasi akibat perubahan hormonal yang berhubungan dengan siklus saat ovulasi dan menstruasi. Salah satu faktor penyebab pre-menstrual syndrome adalah status gizi dan tingkat stres.Desain penelitian yang digunakan adalah penelitian analitik korelasional dengan menggunakan pendekatan cross sectional. Populasi yang diteliti adalah semua remaja putri usia 12-21 tahun di Pondok Pesantren Lirboyo pada Tahun 2016 sejumlah 127 orang dengan teknik simple random sampling analisa dengan menggunakan spearman rank.Hasil analisis diperoleh nilai p value = 0,000 sehingga  p value  α  maka H0 ditolak dan H1 diterima dengan nilai r =- 0,533. Sedangkan variabel tingkat stres dengan kejadian pre-menstrual syndrome, dengan hasil p value = 0,000 sehingga  p value  α  maka H0 ditolak dan H1 diterima dengan nilai r = 0,650. Berdasarkan hasil penelitian diharapkan angka kejadian pre-menstrual syndrome dapat berkurang dengan cara mengenali dini gejala terjadinya pre-menstrual syndrome dan memberikan penyuluhan kepada santri cara mencegah pre-menstrual syndrome. Kata kunci : status gizi, tingkat stres dan pre-menstrual syndrome.   ABSTRACT Pre-Menstrual Syndrome is collection of physical symptoms, psychological and emotion associated with a woman’s menstrual cycle and consistently occur during the luteal phase of the menstrual cycle due to hormonal changes associated with the current cycle of ovulation and menstruation. One of couses factor pre-menstrual syndromeis nutrition status and stress levels. The research design used an analytic corelation research by using the cross sectional approach. The population of this research were young women aged 12-21 years at Pondok Pesantren Lirboyo in 2016 amount 127 peoples with probability sampling type analyse by spearman rank.The analysis result showed that between nutrition status with pre-menstrual syndrome that p value = 0.000, p value α so H0 was rejected and H1 was accepted by r =-0,533.Futhermore, the result showed that between stress levels with pre-menstrual syndrome, get p value = 0.000 so p value α, H0was rejected and H1 was acceptedby r = 0,650. Based on this result was expected that the incident of pre-menstrual syndromecan be decrease by recognize the symptomps of pre-menstrual syndrome and provide counseling to students how to prevent pre-menstrual syndrome. Keywords : nutrition status, stress levels and pre-menstrual syndrome

scholarly journals Paranoid Hostility but Not Depressive Symptoms Associated with Cytokines During the Premenstrual Phase in Young Women

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Syros Ioannis
Keyword(s):  
Depressive Symptoms ◽  
Menstrual Cycle ◽  
Young Women ◽  
Proinflammatory Cytokines ◽  
Luteal Phase ◽  
Depression Scale ◽  
Rank Correlation ◽  
Hormonal Changes ◽  
Mean Values ◽  
Tnf Α

It is well known that some women, during their premenstrual phase, express Hostility (Ho) and Depressive symptoms (De). Various studies indicate that Ho and De correlate with circulating concentrations of cytokines. These data support the hypothesis of an inflammation-sensitive mechanism linked to certain psychological states. The aim of this study was to correlate Ho and De with selective proinflammatory cytokines during the menstrual cycle in young women. Twenty-two physically healthy medical students, mean age 22.95+2.83(SD), were studied. All reported regular menses that ranged between 27-33 days. Blood was drawn three times across a single cycle: at follicular phase (FL), at mid luteal phase (ML) and at late luteal phase (LL) corresponding to the premenstrual phase. The following proinflammatory cytokines were determined at each sample: Interleukin 8 (IL-8), Interleukin 6 (IL-6), Interleukin 1α (IL-1α), and Tumor Necrosis Factor-α (TNF-α). Immediately before blood sampling the women completed the Zung self-rating depression scale and the hostility and direction of hostility questionnaire (HDHQ), which comprises five subscales: urge to act out hostility, criticism of others, paranoid hostility, self-criticism and delusional guilt. Spearman’s rank correlation was used to determine the relation between variables at the specific time points; ρ<0.05 was considered significant. Mean values of cytokines did not change significantly throughout the menstrual cycle. Paranoid hostility was positively correlated with IL-8 (Rs=0.476, p=0.046), IL-1α (Rs=0.458, p=0.048) and TNF-α (Rs=0.518, p=0.023) in LLphase. No other significant correlation was found. Cytokines correlate with paranoid hostility and this correlation is probably related with the premenstrual hormonal changes. It is difficult to evaluate the clinical significance of our findings, nevertheless, when exploring the above association, it is necessary to take into consideration the phase of the cycle as well as the special aspects of Ho we seek to study.

scholarly journals Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pig-Tailed Macaques by Using a Systems Biology Approach

2015 ◽  
Vol 89 (18) ◽  
pp. 9167-9177 ◽  
Author(s):  
S. A. Vishwanathan ◽  
A. Burgener ◽  
S. E. Bosinger ◽  
G. K. Tharp ◽  
P. C. Guenthner ◽  
...  
Keyword(s):  
Systems Biology ◽  
Menstrual Cycle ◽  
Hiv Infection ◽  
Genital Tract ◽  
Luteal Phase ◽  
Female Genital Tract ◽  
High Dose ◽  
Hormonal Changes ◽  
Hiv 1 ◽  
Female Genital

ABSTRACTOur earlier studies with pig-tailed macaques demonstrated various simian-human immunodeficiency virus (SHIV) susceptibilities during the menstrual cycle, likely caused by cyclic variations in immune responses in the female genital tract. There is concern that high-dose, long-lasting, injectable progestin-based contraception could mimic the high-progesterone luteal phase and predispose women to human immunodeficiency type 1 (HIV-1) acquisition and transmission. In this study, we adopted a systems biology approach employing proteomics (tandem mass spectrometry), transcriptomics (RNA microarray hybridization), and other specific protein assays (enzyme-linked immunosorbent assays and multiplex chemokine and cytokine measurements) to characterize the effects of hormonal changes on the expression of innate factors and secreted proteins in the macaque vagina. Several antiviral factors and pathways (including acute-phase response signaling and complement system) were overexpressed in the follicular phase. Conversely, during the luteal phase there were factors overexpressed (including moesins, syndecans, and integrins, among others) that could play direct or indirect roles in enhancing HIV-1 infection. Thus, our study showed that specific pathways and proteins or genes might work in tandem to regulate innate immunity, thus fostering further investigation and future design of approaches to help counter HIV-1 acquisition in the female genital tract.IMPORTANCEHIV infection in women is poorly understood. High levels of the hormone progesterone may make women more vulnerable to infection. This could be the case during the menstrual cycle, when using hormone-based birth control, or during pregnancy. The biological basis for increased HIV vulnerability is not known. We used an animal model with high risk for infection during periods of high progesterone. Genital secretions and tissues during the menstrual cycle were studied. Our goal was to identify biological factors upregulated at high progesterone levels, and we indeed show an upregulation of genes and proteins which enhance the ability of HIV to infect when progesterone is high. In contrast, during low-progesterone periods, we found more HIV inhibitory factors. This study contributes to our understanding of mechanisms that may regulate HIV infection in females under hormonal influences. Such knowledge is needed for the development of novel prevention strategies.

Changes in sodium and uric acid concentrations in plasma during the menstrual cycle.

1984 ◽  
Vol 30 (3) ◽  
pp. 380-381 ◽  
Author(s):  
M Mira ◽  
P M Stewart ◽  
V Gebski ◽  
D Llewellyn-Jones ◽  
S F Abraham
Keyword(s):  
Uric Acid ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Reference Interval ◽  
Hormonal Changes ◽  
Biochemical Variables ◽  
Normal Reference

Abstract Hormonal changes during the menstrual cycle are well documented, but many other biochemical variables have not been studied. We find that in the luteal phase of the menstrual cycle the concentrations of sodium and uric acid are significantly lower. The changes may be of significance for the determination of the normal reference interval.

EVALUATION OF CHANGES IN CARDIORESPIRATORY FUNCTIONS DURING DIFFERENT PHASES OF THE MENSTRUAL CYCLE IN YOUNG WOMEN

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Shehnaz Shaikh
Keyword(s):  
Menstrual Cycle ◽  
Sample Size ◽  
Young Women ◽  
Luteal Phase ◽  
Uterine Wall ◽  
Normal Weight ◽  
Follicular Phase ◽  
Menstrual Phase ◽  
Granulose Cells ◽  
Efficiency Test

Introduction: Menstrual cycle or menstruation involved discharge of sanguinous fluid and a sloughing of uterine wall. In women menstruation occurs at regular intervals on an average of 28 days, although most women gave a history of regular intervals of 28 to 30 days. About 10% -15% of women showed cycle at the precise 28 ± 2 days intervals when menstrual calendar was utilized. Normally in young women in different phases of ovarian cycles the plasma levels of estrogen vary. Ovulation occurs in the first 12-13th day of menstrual cycle, which is termed estrogen surge and second occurs in mid-luteal phase. During mid cycle or follicular phase of menstrual cycle the plasma concentration of progesterone is very low about 0.9 ng/mL. its level starts rising owing to secretion from the granulose cells. During luteal phase progesterone level reaches its peak value of 18 ng/mL and its level fall to a minimum value toward the end of the cycle. Estrogen affects local and systemic vasodilation. The menstrual cycle envelops two fundamental stages, the follicular stage (FP) and the luteal stage (LP). The follicular stage can part advance into two substages; the early FP, which is characterised with moo concentrations of both the key hormones estrogen and progesterone; and the mid FP where estrogen is tall autonomously from progesterone. The LP is epitomized by tall concentration of both estrogen and progesterone. These two fundamental stages are isolated by a soak surge in luteinizing hormone activating ovulation. These recurrent changes are said to be frequency unsurprising while long time. Aim: The main aim of this study is to evaluate the Cardiorespiratory functions changes during different Phases of Menstrual Cycle.   Material and methods: In this study, 20 with normal weight, 20 with obese and 20 with overage were included and taken them as a sample size. In this study all the young women those were recruited as a sample size are unmarried, undergraduate female student with the between the age group of 18-22years, having regular 28+6 days menstrual cycle for at least last 6months prior to this study. For the collection of data all the participants were instructed to attend the physiology lab department during each of three different phases. Day-2 during menstrual phase, Day-7, during follicular phase and Day-22 during luteal phase and the following parameters were recorded as Anthropometric measurements, measuring of pulse rate and blood pressure and cardiac efficiency test. Result: In general, work out proficiency changed essentially amid the distinctive stages of the menstrual cycle with the most elevated amid luteal stage and least amid menstrualo stage. There was no critical contrast in impact test amid menstrual stage, follicular stage and luteal stage of menstrual cycle among three bunches of people. Conclusion: We have watched noteworthy increment in cardiac and respiratory proficiency within the luteal stage of the menstrual cycle in ordinary weight people. Lower wellness levels were watched in overweight and stout females. In this manner hone of customary work out and admissions of solid slim down which offer assistance in lessening the weight and in turn the BMI will offer assistance in improving the physical wellness of the people. Keywords: Cardiorespiratory, Menstrual cycle, expiratory blast test

EFFECT OF LH-RH ON SERUM FSH, LH AND PROGESTERONE DURING THE LUTEAL PHASE OF THE MENSTRUAL CYCLE

1975 ◽  
Vol 80 (1_Suppla) ◽  
pp. S20
Author(s):  
I. Gerhard ◽  
M. Röhrich ◽  
K. Klinga ◽  
B. Runnebaum
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Lh Rh

Features hormonal hemostasis in patients with benign hyper-plastic processes of breasts

2016 ◽  
pp. 72-74 ◽  
Author(s):  
M. Makarenko ◽  
◽  
D. Govsieiev ◽  
O. Gromova ◽  
L. Martynova ◽  
...  
Keyword(s):  
Luteal Phase ◽  
Reproductive Organs ◽  
Breast Diseases ◽  
Hormonal Changes ◽  
Morphological Investigation ◽  
Fibrocystic Disease ◽  
X Ray ◽  
Pelvic Organs ◽  
Hormone Research ◽  
Gynecological Diseases

The objective: to study the incidence of gynecological diseases, clinical and hormonal parameters of the menstrual cycle in patients with benign hyper-plastic processes of breasts. Patients and methods. 65 women with various forms of mastitis were investigated. The following investigations were conducted: mammologistic and gynecological investigation, mommologistic X-ray investigation, ultrasound of breasts and of the pelvic organs, endometrial aspiration biopsy that was followed by cytology; when it was necessary the diagnostic laparoscopy, colposcopy, hysteroscope with curettage and morphological investigation of the endometrium, hormone research and rectal temperature measurements were conducted. Results. The frequency of the benign breast diseases was set: fibrocystic disease of breast – 32 women (49.2±6.20%), fibrous of breast – 16 women (24.6±5.34%), nodular of breasts – 8 women (12.3±4.07%), fibroadenoma – 6 women (9.2±3.59%), nodular disease of breasts on the background of fibroid changes – 3 women (4.6±2.60%). All in all, 96.9±2.14% of the patients had any gynecological diseases. Thus, the average age of the ‘debut’ of mastitis was 31.4±1.09 years; the hyper-plastic processes in the uterus was 35.2±1.17 years. Anovulation was detected in 17 (47.2±8.3%) patients, the lack of the luteal phase (NLF) was detected in 11 (30.6±7.6) patients. Conclusions. Identified hormonal changes are typical for patients with the hyper-plastic processes of the reproductive organs with different localization (breasts, uterus, ovaries). Due to the commonality of the hormone changes in most cases mastitis is combined with the various gynecological diseases (96.9±2.14%). Key words: gynecological pathology, hormonal changes, breast, factors of risk.

scholarly journals Influence of Menstrual Cycle Estradiol-β-17 Fluctuations on Energy Substrate Utilization-Oxidation during Aerobic, Endurance Exercise

2021 ◽  
Vol 18 (13) ◽  
pp. 7209
Author(s):  
Hannah N. Willett ◽  
Kristen J. Koltun ◽  
Anthony C. Hackney
Keyword(s):  
Menstrual Cycle ◽  
Athletic Performance ◽  
Luteal Phase ◽  
Substrate Utilization ◽  
Follicular Phase ◽  
Exercise Session ◽  
Future Research ◽  
Physically Active ◽  
Energy Substrate ◽  
Fat Utilization

This study examined the effect of estradiol-β-17 across the menstrual cycle (MC) during aerobic exercise on energy substrate utilization and oxidation. Thirty-two eumenorrheic (age = 22.4 ± 3.8 y (mean ± SD)), physically active women participated in two steady-state running sessions at 65% of VO2max, one during the early follicular and one during the luteal phase of the MC. Blood samples were collected at rest before each exercise session and analyzed for Estradiol-β-17 to confirm the MC phase. Carbohydrate (CHO) utilization and oxidation values were significantly lower (p < 0.05) in the luteal (utilization: 51.6 ± 16.7%; oxidation: 1.22 ± 0.56 g/min; effect size (ES) = 0.45, 0.27) than follicular phase (utilization: 58.2 ± 15.1%; oxidation: 1.38 ± 0.60 g/min) exercise sessions. Conversely, fat utilization and oxidation values were significantly (p < 0.05) higher in the luteal (utilization: 48.4 ± 16.7%; oxidation: 0.49 ± 0.19 g/min; ES = 0.45,0.28) than follicular phase (utilization: 41.8 ± 15.1%; oxidation: 0.41 ± 0.14 g/min). Estradiol-β-17 concentrations were significantly (p < 0.01) greater during the luteal (518.5 ± 285.4 pmol/L; ES = 0.75) than follicular phase (243.8 ± 143.2 pmol/L). Results suggest a greater use of fat and reduced amount of CHO usage during the luteal versus follicular phase, directly related to the change in resting estradiol-β-17. Future research should investigate the role these changes may play in female athletic performance.

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