Peanut lectin-induced proliferation of HT29 human colon cancer cells is mediated by activation of mitogen-activated protein kinase (MAPK)

2000 ◽  
Vol 118 (4) ◽  
pp. A614
Author(s):  
Ravinder Singh ◽  
Lu-Gang Yu ◽  
David G. Fernig ◽  
Maryse Delehedde ◽  
Barry J. Campbell ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Human Colon ◽  
Mitogen Activated Protein Kinase ◽  
Colon Cancer Cells ◽  
Peanut Lectin ◽  
Human Colon Cancer ◽  
Mitogen Activated Protein ◽  
Human Colon Cancer Cells

Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells

1999 ◽  
Vol 117 (4) ◽  
pp. 848-857 ◽  
Author(s):  
Shaun G. Weller ◽  
Irene K. Klein ◽  
Robert C. Penington ◽  
William E. Karnes
Keyword(s):  
Colon Cancer ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Kinase C ◽  
Human Colon Cancer Cells

Combined effects of protein kinase inhibitors and 5-fluorouracil on CEA expression in human colon cancer cells

2005 ◽  
Vol 52 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Salvatore Pasquale Prete ◽  
Lorena Rossi ◽  
Pier Paolo Correale ◽  
Mario Turriziani ◽  
Susanne Baier ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Kinase Inhibitors ◽  
Human Colon ◽  
Protein Kinase Inhibitors ◽  
Combined Effects ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals Oyaksungisan, a Traditional Herbal Formula, Inhibits Cell Proliferation by Induction of AutophagyviaJNK Activation in Human Colon Cancer Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Nam-Hui Yim ◽  
Young Pil Jung ◽  
Aeyung Kim ◽  
Choong Je Ma ◽  
Won-Kyung Cho ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Human Colon ◽  
Mitogen Activated Protein Kinase ◽  
Herbal Formula ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells ◽  
Hct116 Cells

Oyaksungisan (OY) is a traditional herbal formula broadly used to treat beriberi, vomiting, diarrhea, and circulatory disturbance in Asian countries from ancient times. The effect of OY on cancer, however, was not reported until now. In this study, we have demonstrated that OY inhibits cell proliferation and induces cell deathviamodulating the autophagy on human colon cancer cells. In HCT116 cells, OY increased the ratio of LC3-II/LC3-I, a marker of autophagy, and treatment with 3-MA, an inhibitor of autophagy, and considerably reduced the formation of autophagosomes. In addition, OY regulated mitogen-activated protein kinase (MAPK) cascades; especially, JNK activation was closely related with autophagy effect by OY in HCT116 cells. Our results indicate that autophagy induction is responsible for the antiproliferative effect by OY, despite the weak apoptosis induction in HCT116 cells. In conclusion, OY might have a potential to be developed as an herbal anticancer remedy.

Activation of Protein Kinase G Up-regulates Expression of 15-Lipoxygenase-1 in Human Colon Cancer Cells

2005 ◽  
Vol 65 (18) ◽  
pp. 8442-8447 ◽  
Author(s):  
Atsuko Deguchi ◽  
Steven W. Xing ◽  
Imad Shureiqi ◽  
Peiying Yang ◽  
Robert A. Newman ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Human Colon ◽  
Protein Kinase G ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells
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