I1307K APC gene variant has no clinical implication in Israeli jews at average or high risk for colorectal neoplasia

2001 ◽  
Vol 120 (5) ◽  
pp. A120-A121
Author(s):  
H STRUL ◽  
E BIRENBAUM ◽  
B STERN ◽  
D KAZANOV ◽  
L THEODOR ◽  
...  
Keyword(s):  
High Risk ◽  
Clinical Implication ◽  
Colorectal Neoplasia ◽  
Apc Gene ◽  
Gene Variant

I1307K APC gene variant has no clinical implication in Israeli jews at average or high risk for colorectal neoplasia

2001 ◽  
Vol 120 (5) ◽  
pp. A120-A121
Author(s):  
Hana Strul ◽  
Erez Birenbaum ◽  
Baruch Stern ◽  
Dina Kazanov ◽  
Livia Theodor ◽  
...  
Keyword(s):  
High Risk ◽  
Clinical Implication ◽  
Colorectal Neoplasia ◽  
Apc Gene ◽  
Gene Variant

W1980 Rectal Aberrant Crypt Foci (ACF) Among Subjects with a History of High-Risk Colorectal Neoplasia (CRN).

2009 ◽  
Vol 136 (5) ◽  
pp. A-766
Author(s):  
Paul J. Limburg ◽  
Michelle R. Mahoney ◽  
Stephen J. Sontag ◽  
Robert E. Schoen ◽  
Richard V. Benya ◽  
...  
Keyword(s):  
High Risk ◽  
Colorectal Neoplasia ◽  
Aberrant Crypt Foci ◽  
History Of

scholarly journals Clinical implication of surgically treated early-stage cervical cancer with multiple high-risk factors

2015 ◽  
Vol 26 (1) ◽  
pp. 3 ◽  
Author(s):  
Koji Matsuo ◽  
Seiji Mabuchi ◽  
Mika Okazawa ◽  
Mahiru Kawano ◽  
Hiromasa Kuroda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
High Risk ◽  
Clinical Implication ◽  
Early Stage ◽  
High Risk Factors ◽  
Early Stage Cervical Cancer

Faecal occult blood testing and colonoscopy in the surveillance of subjects at high risk of colorectal neoplasia

1995 ◽  
Vol 82 (3) ◽  
pp. 318-320 ◽  
Author(s):  
M. H. E. Robinson ◽  
O. Kronborg ◽  
C. B. Williams ◽  
K. Bostock ◽  
P. S. Rooney ◽  
...  
Keyword(s):  
High Risk ◽  
Colorectal Neoplasia ◽  
Occult Blood ◽  
Faecal Occult Blood Testing ◽  
Blood Testing ◽  
Faecal Occult Blood ◽  
Faecal Occult

scholarly journals Consecutive negative findings on colonoscopy during surveillance predict a low risk of advanced neoplasia in patients with inflammatory bowel disease with long-standing colitis: results of a 15-year multicentre, multinational cohort study

Gut ◽  
2018 ◽  
Vol 68 (4) ◽  
pp. 615-622 ◽  
Author(s):  
Joren R ten Hove ◽  
Shailja C Shah ◽  
Seth R Shaffer ◽  
Charles N Bernstein ◽  
Daniel Castaneda ◽  
...  
Keyword(s):  
High Risk ◽  
Colorectal Neoplasia ◽  
Low Risk ◽  
Surveillance Colonoscopy ◽  
Time Intervals ◽  
Index Procedure ◽  
Advanced Colorectal Neoplasia ◽  
Negative Findings ◽  
Inflammatory Bowel

ObjectivesSurveillance colonoscopy is thought to prevent colorectal cancer (CRC) in patients with long-standing colonic IBD, but data regarding the frequency of surveillance and the findings thereof are lacking. Our aim was to determine whether consecutive negative surveillance colonoscopies adequately predict low neoplastic risk.DesignA multicentre, multinational database of patients with long-standing IBD colitis without high-risk features and undergoing regular CRC surveillance was constructed. A ‘negative’ surveillance colonoscopy was predefined as a technically adequate procedure having no postinflammatory polyps, no strictures, no endoscopic disease activity and no evidence of neoplasia; a ‘positive’ colonoscopy was a technically adequate procedure that included at least one of these criteria. The primary endpoint was advanced colorectal neoplasia (aCRN), defined as high-grade dysplasia or CRC.ResultsOf 775 patients with long-standing IBD colitis, 44% (n=340) had >1 negative colonoscopy. Patients with consecutive negative surveillance colonoscopies were compared with those who had at least one positive colonoscopy. Both groups had similar demographics, disease-related characteristics, number of surveillance colonoscopies and time intervals between colonoscopies. No aCRN occurred in those with consecutive negative surveillance, compared with an incidence rate of 0.29 to 0.76/100 patient-years (P=0.02) in those having >1 positive colonoscopy on follow-up of 6.1 (P25–P75: 4.6–8.2) years after the index procedure.ConclusionWithin this large surveillance cohort of patients with colonic IBD and no additional high-risk features, having two consecutive negative colonoscopies predicted a very low risk of aCRN occurrence on follow-up. Our findings suggest that longer surveillance intervals in this selected population may be safe.

scholarly journals Colonoscopy uptake for high-risk individuals with a family history of colorectal neoplasia

Medicine ◽  
2016 ◽  
Vol 95 (33) ◽  
pp. e4303 ◽  
Author(s):  
Isabelle Ingrand ◽  
Gautier Defossez ◽  
Jean-Pierre Richer ◽  
David Tougeron ◽  
Nicolas Palierne ◽  
...  
Keyword(s):  
Family History ◽  
High Risk ◽  
Colorectal Neoplasia ◽  
History Of

Derivation and validation of a predictive model for advanced colorectal neoplasia in asymptomatic adults

Gut ◽  
2020 ◽  
pp. gutjnl-2020-321698
Author(s):  
Thomas F Imperiale ◽  
Patrick O Monahan ◽  
Timothy E Stump ◽  
David F Ransohoff
Keyword(s):  
High Risk ◽  
Colorectal Neoplasia ◽  
Risk Groups ◽  
Low Risk ◽  
Screening Tests ◽  
Screening Colonoscopy ◽  
Average Risk ◽  
Intermediate Risk ◽  
C Statistic ◽  
Advanced Colorectal Neoplasia

ObjectiveKnowing risk for advanced colorectal neoplasia (AN) could help patients and providers choose among screening tests, improving screening efficiency and uptake. We created a risk prediction model for AN to help decide which test might be preferred, a use not considered for existing models.DesignAverage-risk 50-to-80-year olds undergoing first-time screening colonoscopy were recruited from endoscopy units in Indiana. We measured sociodemographic and physical features, medical and family history and lifestyle factors and linked these to the most advanced finding. We derived a risk equation on two-thirds of the sample and assigned points to each variable to create a risk score. Scores with comparable risks were collapsed into risk categories. The model and score were tested on the remaining sample.ResultsAmong 3025 subjects in the derivation set (mean age 57.3 (6.5) years; 52% women), AN prevalence was 9.4%. The 13-variable model (c-statistic=0.77) produced three risk groups with AN risks of 1.5% (95% CI 0.72% to 2.74%), 7.06% (CI 5.89% to 8.38%) and 27.26% (CI 23.47% to 31.30%) in low-risk, intermediate-risk and high-risk groups (p value <0.001), containing 23%, 59% and 18% of subjects, respectively. In the validation set of 1475 subjects (AN prevalence of 8.4%), model performance was comparable (c-statistic=0.78), with AN risks of 2.73% (CI 1.25% to 5.11%), 5.57% (CI 4.12% to 7.34%) and 25.79% (CI 20.51% to 31.66%) in low-risk, intermediate-risk and high-risk subgroups, respectively (p<0.001), containing proportions of 23%, 59% and 18%.ConclusionAmong average-risk persons, this model estimates AN risk with high discrimination, identifying a lower risk subgroup that may be screened non-invasively and a higher risk subgroup for which colonoscopy may be preferred. The model could help guide patient–provider discussions of screening options, may increase screening adherence and conserve colonoscopy resources.

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