Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindreds

2003 ◽  
Vol 124 (5) ◽  
pp. 1292-1299 ◽  
Author(s):  
Stephen J Rulyak ◽  
Albert B Lowenfels ◽  
Patrick Maisonneuve ◽  
Teresa A Brentnall
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Familial Pancreatic Cancer

Risk Factors of Familial Pancreatic Cancer in Japan

Pancreas ◽  
2011 ◽  
Vol 40 (6) ◽  
pp. 974-978 ◽  
Author(s):  
Hiroyuki Matsubayashi ◽  
Atsuyuki Maeda ◽  
Hideyuki Kanemoto ◽  
Katsuhiko Uesaka ◽  
Kentaro Yamazaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Familial Pancreatic Cancer

scholarly journals Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1612
Author(s):  
Julie Earl ◽  
Emma Barreto ◽  
María E. Castillo ◽  
Raquel Fuentes ◽  
Mercedes Rodríguez-Garrote ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Overall Survival ◽  
Somatic Mutation ◽  
Disease Status ◽  
Clinical Analysis ◽  
Cytotoxic Agents ◽  
Disease Stage ◽  
Ductal Adenocarcinoma ◽  
Familial Pancreatic Cancer ◽  
Circulating Free Dna

Pancreatic ductal adenocarcinoma (PDAC) presents many challenges in the clinic and there are many areas for improvement in diagnostics and patient management. The five-year survival rate is around 7.2% as the majority of patients present with advanced disease at diagnosis that is treatment resistant. Approximately 10–15% of PDAC cases have a hereditary basis or Familial Pancreatic Cancer (FPC). Here we demonstrate the use of circulating free DNA (cfDNA) in plasma as a prognostic biomarker in PDAC. The levels of cfDNA correlated with disease status, disease stage, and overall survival. Furthermore, we show for the first time via BEAMing that the majority of hereditary or familial PDAC cases (around 84%) are negative for a KRAS somatic mutation. In addition, KRAS mutation negative cases harbor somatic mutations in potentially druggable genes such as KIT, PDGFR, MET, BRAF, and PIK3CA that could be exploited in the clinic. Finally, familial or hereditary cases have a longer overall survival compared to sporadic cases (10.2 vs. 21.7 months, respectively). Currently, all patients are treated the same in the clinic with cytotoxic agents, although here we demonstrate that there are different subtypes of tumors at the genetic level that could pave the way to personalized treatment.

scholarly journals Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer

2015 ◽  
Vol 6 (2) ◽  
pp. 166-175 ◽  
Author(s):  
Nicholas J. Roberts ◽  
Alexis L. Norris ◽  
Gloria M. Petersen ◽  
Melissa L. Bondy ◽  
Randall Brand ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Genetic Heterogeneity ◽  
Familial Pancreatic Cancer ◽  
Whole Genome

Risk independence for the identification of cystic lesions in Familial Pancreatic Cancer (FPC) kindreds

Pancreatology ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. S68
Author(s):  
Andrea Sheel ◽  
Sara Harrison ◽  
Ioannis Sarantitis ◽  
James Nicholson ◽  
Christopher Halloran ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Familial Pancreatic Cancer ◽  
Cystic Lesions

Risk factors and early signs of pancreatic cancer in diabetes: screening strategy based on diabetes onset age

2012 ◽  
Vol 48 (2) ◽  
pp. 238-246 ◽  
Author(s):  
Suguru Mizuno ◽  
Yousuke Nakai ◽  
Hiroyuki Isayama ◽  
Ayako Yanai ◽  
Naminatsu Takahara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Screening Strategy ◽  
Onset Age ◽  
Diabetes Screening ◽  
Diabetes Onset ◽  
Early Signs

Fr336 RISK FACTORS FOR DEVELOPMENT OF PANCREATIC CANCER AMONG PATIENTS WITH CHRONIC PANCREATITIS: A CASE-CONTROL STUDY

2021 ◽  
Vol 160 (6) ◽  
pp. S-297-S-298
Author(s):  
Mark Kowalczyk ◽  
Sridevi K. Pokala ◽  
Joshua Demb ◽  
Fady Youssef ◽  
Lin Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Update on familial pancreatic cancer

2001 ◽  
Vol 3 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Henry T. Lynch ◽  
Randall E. Brand ◽  
Carolyn A. Deters ◽  
Ramon M. Fusaro
Keyword(s):  
Pancreatic Cancer ◽  
Familial Pancreatic Cancer
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