M1342 Pain Associated With Irritable Bowel Syndrome is a Major Unmet Need Among IBS Sufferers

2010 ◽  
Vol 138 (5) ◽  
pp. S-384
Author(s):  
Daniel W. Gil ◽  
Rozalina Dimitrova ◽  
Simon Daggett ◽  
Peter Sissins ◽  
Wayne Lam ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Unmet Need ◽  
Irritable Bowel

scholarly journals British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Gut ◽  
2021 ◽  
pp. gutjnl-2021-324598
Author(s):  
Dipesh H Vasant ◽  
Peter A Paine ◽  
Christopher J Black ◽  
Lesley A Houghton ◽  
Hazel A Everitt ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Evaluation System ◽  
Unmet Need ◽  
Gastrointestinal Disorder ◽  
British Society ◽  
Current Evidence ◽  
Future Research ◽  
Novel Treatments ◽  
Psychological Therapies ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders seen by clinicians in both primary and secondary care. Since publication of the last British Society of Gastroenterology (BSG) guideline in 2007, substantial advances have been made in understanding its complex pathophysiology, resulting in its re-classification as a disorder of gut-brain interaction, rather than a functional gastrointestinal disorder. Moreover, there has been a considerable amount of new evidence published concerning the diagnosis, investigation and management of IBS. The primary aim of this guideline, commissioned by the BSG, is to review and summarise the current evidence to inform and guide clinical practice, by providing a practical framework for evidence-based management of patients. One of the strengths of this guideline is that the recommendations for treatment are based on evidence derived from a comprehensive search of the medical literature, which was used to inform an update of a series of trial-based and network meta-analyses assessing the efficacy of dietary, pharmacological and psychological therapies in treating IBS. Specific recommendations have been made according to the Grading of Recommendations Assessment, Development and Evaluation system, summarising both the strength of the recommendations and the overall quality of evidence. Finally, this guideline identifies novel treatments that are in development, as well as highlighting areas of unmet need for future research.

scholarly journals Diarrhea-Predominant Irritable Bowel Syndrome: Medical Management Update

2019 ◽  
Author(s):  
Christopher N Andrews ◽  
Marc Bradette
Keyword(s):  
Irritable Bowel Syndrome ◽  
Treatment Options ◽  
Unmet Need ◽  
Work Productivity ◽  
Clinical Trial Data ◽  
Gastrointestinal Disorder ◽  
Lifestyle Modifications ◽  
Individualized Approach ◽  
Irritable Bowel ◽  
Dietary Modifications

Abstract Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder, which impacts the quality of life, work productivity and social activities of patients. Diarrhea-predominant IBS (IBS-D) is one of several subtypes, and accounts for approximately one third of all cases. Currently available treatments are typically unable to alleviate the cardinal symptoms of IBS-D, including abdominal pain and diarrhea, and a clinical unmet need remains for an effective treatment which simultaneously relieves multiple symptoms. Patients may benefit from a multipronged, individualized approach, including dietary modifications, and psychological and pharmacological therapies. The aim of this review is to provide an update on the available and upcoming treatment options for IBS-D in Canada, with reference to the recently updated Canadian IBS consensus guidelines. Initial treatment approaches include lifestyle modifications, dietary modifications, and non-prescription therapies such as peppermint oil. While some medications such as tricyclic antidepressants are also used to treat IBS-D symptoms, eluxadoline and rifaximin are the only two pharmacological therapies approved for the treatment of IBS-D in Canada. Key clinical trial data for the currently available pharmacological options are presented to provide an overview of the efficacy and safety of these agents

Motor and sensory function of the rectum in different types of irritable bowel syndrome

2001 ◽  
Vol 120 (5) ◽  
pp. A399-A399
Author(s):  
J STEENS ◽  
P SCHAAR ◽  
C LAMERS ◽  
A MASCLEE
Keyword(s):  
Irritable Bowel Syndrome ◽  
Sensory Function ◽  
Different Types ◽  
Irritable Bowel

How restrictive are Rome II criteria for the diagnosis of the irritable bowel syndrome (IBS)?

2001 ◽  
Vol 120 (5) ◽  
pp. A231-A231
Author(s):  
F MEARIN ◽  
X BADIA
Keyword(s):  
Irritable Bowel Syndrome ◽  
Rome Ii Criteria ◽  
Irritable Bowel

Rome I versus Rome II; Overlap in patients enrolled in tegaserod phase III clinical trials for irritable bowel syndrome (IBS)

2001 ◽  
Vol 120 (5) ◽  
pp. A284-A284
Author(s):  
B NAULT ◽  
S SUE ◽  
J HEGGLAND ◽  
S GOHARI ◽  
G LIGOZIO ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Irritable Bowel Syndrome ◽  
Phase Iii ◽  
Phase Iii Clinical Trials ◽  
Irritable Bowel ◽  
Rome I

Alterations in regional decreased cerebral blood flow in patients with irritable bowel syndrome-A PET imaging study

2001 ◽  
Vol 120 (5) ◽  
pp. A637-A637
Author(s):  
Y RINGEL ◽  
D DROSSMAN ◽  
T TURKINGTON ◽  
B BRADSHAW ◽  
R COLEMAN ◽  
...  
Keyword(s):  
Blood Flow ◽  
Irritable Bowel Syndrome ◽  
Cerebral Blood Flow ◽  
Pet Imaging ◽  
Imaging Study ◽  
Irritable Bowel

Health releated quality of life in irritable bowel syndrome: A community based study+

2001 ◽  
Vol 120 (5) ◽  
pp. A634-A634 ◽  
Author(s):  
K OLDEN ◽  
W CHEY ◽  
J BOYLE ◽  
E CARTER ◽  
L CHANG
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Community Based ◽  
Irritable Bowel

Differences in productivity QOL, and resource use in newly diagnosed and established irritable bowel syndrome (IBS) patients

2001 ◽  
Vol 120 (5) ◽  
pp. A634-A634
Author(s):  
P JHINGRAN ◽  
J RICCI ◽  
M MARKOWITZ ◽  
S GORDON ◽  
A ASGHARIAN ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Resource Use ◽  
Newly Diagnosed ◽  
Irritable Bowel

Screening for coeliac disease in patients with clinical diagnosis of irritable bowel syndrome

2001 ◽  
Vol 120 (5) ◽  
pp. A757-A757 ◽  
Author(s):  
R HOLT ◽  
S DARNLEY ◽  
T KENNEDY ◽  
R JONES
Keyword(s):  
Irritable Bowel Syndrome ◽  
Coeliac Disease ◽  
Clinical Diagnosis ◽  
Irritable Bowel
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