Molecular Subtypes Combining CpG Island Methylator Phenotype (CIMP) and TP53 Hot Spot Mutation Status Provide Distinct Clinicopathological Features in Gastric Cancer

2017 ◽  
Vol 152 (5) ◽  
pp. S1027-S1028
Author(s):  
Tomomitsu Tahara ◽  
Masaaki Okubo ◽  
Tomohiko Kawamura ◽  
Noriyuki Horiguchi ◽  
Takamitsu Ishizuka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Molecular Subtypes ◽  
Cpg Island ◽  
Hot Spot ◽  
Clinicopathological Features ◽  
Cpg Island Methylator Phenotype ◽  
Mutation Status ◽  
Methylator Phenotype

Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer

Epigenomics ◽  
2019 ◽  
Vol 11 (15) ◽  
pp. 1651-1659
Author(s):  
Sayumi Tahara ◽  
Tomomitsu Tahara ◽  
Noriyuki Horiguchi ◽  
Masaaki Okubo ◽  
Tsuyoshi Terada ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Mucosa ◽  
Cpg Island ◽  
Methylation Status ◽  
Promoter Hypermethylation ◽  
Cpg Island Methylator Phenotype ◽  
Line1 Methylation ◽  
Methylator Phenotype ◽  
H Pylori ◽  
Mlh1 Methylation

Aim: To investigate the associations between LINE1 methylation, an indicator for genome-wide hypomethylation, molecular and clinicopathological characteristics of gastric cancer (GC) patients. Patients & methods: LINE1 methylation statuses were examined in paired cancerous, non-neoplastic mucosa from 217 GC and gastric mucosa from separate group of 224 noncancer patients. CpG island methylator phenotype, TP53 and KRAS mutation, MLH1 methylation status and promoter hypermethylation of GC related and H. pylori-related genes were examined. Results: Lower LINE1 methylation was observed in primary GC compared with non-neoplastic gastric mucosa and associated with CpG island methylator phenotype, TP53 mutation, MLH1 methylation and promoter hypermethylation of GC related and H. pylori-related genes. Conclusion: Lower LINE1 methylation correlates specific molecular subtypes and promoter hypermethylation in GC.

scholarly journals Prognostic value of CpG island methylator phenotype in gastric cancer

2018 ◽  
Vol 109 (8) ◽  
pp. 2623-2625 ◽  
Author(s):  
Huashi Xiao ◽  
Jiaxin Fu ◽  
Masanobu Abe ◽  
Jiafu Ji ◽  
Liang Zong
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype

scholarly journals High CpG island methylator phenotype is associated with lymph node metastasis and prognosis in gastric cancer

2011 ◽  
Vol 103 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Hua-Yun Chen ◽  
Bao-He Zhu ◽  
Chang-Hua Zhang ◽  
Dong-Jie Yang ◽  
Jian-Jun Peng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Node Metastasis ◽  
Methylator Phenotype

scholarly journals Molecular Subtypes of Colorectal Cancer and Their Clinicopathologic Features, With an Emphasis on the Serrated Neoplasia Pathway

2016 ◽  
Vol 140 (5) ◽  
pp. 406-412 ◽  
Author(s):  
Jeong Mo Bae ◽  
Jung Ho Kim ◽  
Gyeong Hoon Kang
Keyword(s):  
Colorectal Cancer ◽  
Complex Disease ◽  
Molecular Subtypes ◽  
Cpg Island ◽  
Colorectal Cancers ◽  
Cpg Island Methylator Phenotype ◽  
Molecular Features ◽  
Methylator Phenotype ◽  
Serrated Neoplasia Pathway ◽  
Molecular Carcinogenesis

Context.—Colorectal cancer is a heterogeneous disease entity with 3 molecular carcinogenesis pathways and 2 morphologic multistep pathways. Right-sided colon cancers and left-sided colon and rectal cancers exhibit differences in their incidence rates according to geographic region, age, and sex. A linear tendency toward increasing frequencies of microsatellite instability–high or CpG island methylator phenotype–high cancers in subsites along the bowel from the rectum to the cecum or the ascending colon accounts for the differences in tumor phenotypes associated with these subsites. The molecular subtypes of colorectal cancers exhibit different responses to adjuvant therapy, which might be responsible for differences in subtype-specific survival. Objectives.—To review the clinicopathologic and molecular features of the molecular subtypes of colorectal cancer generated by combined CpG island methylator phenotype and microsatellite statuses, to integrate these features with the most recent findings in the context of the prognostic implications of molecular subtypes, and to emphasize the necessity of developing molecular markers that enable the identification of adenocarcinomas involving the serrated neoplasia pathway. Data Sources.—Based on the authors' own experimental data and a review of the pertinent literature. Conclusions.—Because colorectal cancers arise from 2 different morphologic multistep carcinogenesis pathways with varying contributions from 3 different molecular carcinogenesis pathways, colorectal cancer is a heterogeneous and complex disease. Thus, molecular subtyping of colorectal cancers is an important approach to characterizing their heterogeneity with respect to not only prognosis and therapeutic response but also biology and natural history.

scholarly journals Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130409 ◽  
Author(s):  
Kunitoshi Shigeyasu ◽  
Takeshi Nagasaka ◽  
Yoshiko Mori ◽  
Naosuke Yokomichi ◽  
Takashi Kawai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Prognostic Markers ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype ◽  
Mlh1 Methylation

scholarly journals Increased Frequency of CpG Island Methylator Phenotype and CDH1 Methylation in a Gastric Cancer High-Risk Region of China

2008 ◽  
Vol 1 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Kai-Li Zhang ◽  
Yuan Sun ◽  
Yan Li ◽  
Ming Liu ◽  
Bo Qu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype
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