DNA Methylation of Multiple Genes in Gastric Cancer: Association with CpG Island Methylator Phenotype and Helicobacter pylori Infection

2006 ◽  
Vol 6 (4) ◽  
pp. 227 ◽  
Author(s):  
Kyong Hwa Jun ◽  
Yong Sung Won ◽  
Eun Young Shin ◽  
Hyun Min Cho ◽  
Myoung Goo Im ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Helicobacter Pylori ◽  
Cpg Island ◽  
Helicobacter Pylori Infection ◽  
Cpg Island Methylator Phenotype ◽  
Multiple Genes ◽  
Methylator Phenotype

scholarly journals DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Marie Loh ◽  
Natalia Liem ◽  
Aparna Vaithilingam ◽  
Pei Li Lim ◽  
Nur Sabrina Sapari ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype

DNA methylation of multiple genes in gastric carcinoma: Association with histological type and CpG island methylator phenotype

2003 ◽  
Vol 94 (10) ◽  
pp. 901-905 ◽  
Author(s):  
Naohide Oue ◽  
Yasuhiro Oshimo ◽  
Hirofumi Nakayama ◽  
Reiko Ito ◽  
Kazuhiro Yoshida ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gastric Carcinoma ◽  
Cpg Island ◽  
Histological Type ◽  
Cpg Island Methylator Phenotype ◽  
Multiple Genes ◽  
Methylator Phenotype

Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer

Epigenomics ◽  
2019 ◽  
Vol 11 (15) ◽  
pp. 1651-1659
Author(s):  
Sayumi Tahara ◽  
Tomomitsu Tahara ◽  
Noriyuki Horiguchi ◽  
Masaaki Okubo ◽  
Tsuyoshi Terada ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Mucosa ◽  
Cpg Island ◽  
Methylation Status ◽  
Promoter Hypermethylation ◽  
Cpg Island Methylator Phenotype ◽  
Line1 Methylation ◽  
Methylator Phenotype ◽  
H Pylori ◽  
Mlh1 Methylation

Aim: To investigate the associations between LINE1 methylation, an indicator for genome-wide hypomethylation, molecular and clinicopathological characteristics of gastric cancer (GC) patients. Patients & methods: LINE1 methylation statuses were examined in paired cancerous, non-neoplastic mucosa from 217 GC and gastric mucosa from separate group of 224 noncancer patients. CpG island methylator phenotype, TP53 and KRAS mutation, MLH1 methylation status and promoter hypermethylation of GC related and H. pylori-related genes were examined. Results: Lower LINE1 methylation was observed in primary GC compared with non-neoplastic gastric mucosa and associated with CpG island methylator phenotype, TP53 mutation, MLH1 methylation and promoter hypermethylation of GC related and H. pylori-related genes. Conclusion: Lower LINE1 methylation correlates specific molecular subtypes and promoter hypermethylation in GC.

scholarly journals Prognostic value of CpG island methylator phenotype in gastric cancer

2018 ◽  
Vol 109 (8) ◽  
pp. 2623-2625 ◽  
Author(s):  
Huashi Xiao ◽  
Jiaxin Fu ◽  
Masanobu Abe ◽  
Jiafu Ji ◽  
Liang Zong
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype

scholarly journals High CpG island methylator phenotype is associated with lymph node metastasis and prognosis in gastric cancer

2011 ◽  
Vol 103 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Hua-Yun Chen ◽  
Bao-He Zhu ◽  
Chang-Hua Zhang ◽  
Dong-Jie Yang ◽  
Jian-Jun Peng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Node Metastasis ◽  
Methylator Phenotype
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