Sa1975 - Survival Analysis Based on Relationship Between Lewis Antigen and Carbohydrate Antigen 19-9 in 1115 Patiens with Pancreatic Cancer in 1115 Asian Population

AbstractAlthough serum markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) have been widely used in screening for pancreatic cancer (PC), their sensitivity and specificity are unsatisfactory. Recently, a novel tool of analyzing serum using the short-time Fourier transform (STFT) of free induction decays (FIDs) obtained by 1H-NMR has been introduced. We for the first time evaluated the utility of this technology as a diagnostic tool for PC. Serum was obtained from PC patients before starting any treatments. Samples taken from individuals with benign diseases or donors for liver transplantation were obtained as controls. Serum samples from both groups underwent 1H-NMR and STFT of FIDs. STFT data were analyzed by partial least squares discriminant analysis (PLS-DA) to clarify whether differences were apparent between groups. As a result, PLS-DA score plots indicated that STFT of FIDs enabled effective classification of groups with and without PC. Additionally, in a subgroup of PC, long-term survivors (≥ 2 years) could be discriminated from short-term survivors (< 2 years), regardless of pathologic stage or CEA or CA19-9 levels. In conclusion, STFT of FIDs obtained from 1H-NMR have a potential to be a diagnostic and prognostic tool of PC.

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The clinical utility of normal range carbohydrate antigen 19-9 level as a surrogate marker in evaluating response to treatment in pancreatic cancer—a report of two cases

Journal of Gastrointestinal Oncology ◽

10.21037/jgo.2016.01.05 ◽

2016 ◽

Vol 7 (3) ◽

pp. E45-E51 ◽

Cited By ~ 15

Author(s):

Humaid O. Al-Shamsi ◽

Mohammed Alzahrani ◽

Robert A. Wolff

Keyword(s):

Pancreatic Cancer ◽

Clinical Utility ◽

Surrogate Marker ◽

Carbohydrate Antigen ◽

Response To Treatment ◽

Normal Range

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Predictive Value of Serum Carbohydrate Antigen 19-9 (CA19-9) for Early Mortality in Advanced Pancreatic Cancer

Journal of Gastrointestinal Cancer ◽

10.1007/s12029-017-0007-x ◽

2017 ◽

Vol 49 (4) ◽

pp. 481-486 ◽

Cited By ~ 6

Author(s):

Pedro L. S. Usón Junior ◽

Donato Callegaro-Filho ◽

Diogo D. G. Bugano ◽

Fernando Moura ◽

Fernando C. Maluf

Keyword(s):

Pancreatic Cancer ◽

Predictive Value ◽

Advanced Pancreatic Cancer ◽

Carbohydrate Antigen ◽

Early Mortality ◽

Serum Carbohydrate Antigen

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(A Clinicopathological Aspects of Resectable Pancreatic Neoplasm)

Gevher Nesibe Journal, IESDR ◽

10.46648/gnj.274 ◽

2021 ◽

Vol 6 (15) ◽

pp. 39-44

Author(s):

Şeref Dokcu ◽

Mehmet Ali Çaparlar ◽

Salim Demirci

Keyword(s):

Pancreatic Cancer ◽

Survival Analysis ◽

Survival Rates ◽

Pancreatic Neoplasm ◽

Population Based ◽

Clinicopathological Features ◽

Categorical Variables ◽

Malignant Neoplasms ◽

Continuous Variables ◽

Common Diagnosis

Aim Pancreatic cancer is one of the deadliest malignant neoplasms. As with many malignant neoplasms, survival rates depend on the histopathological type of cancer, its stage, tumor size, and treatment. In this study, we aimed to classify pancreatic cancer according to clinicopathological features and histological subtypes. Material and method The data of all adult patients diagnosed and treated for pancreatic neoplasm in our clinic were collected retrospectively from the hospital's computerized database and medical files. Patients were categorized according to their clinicopathological features. Chi-square test and Fisher's exact test were used for between-group comparisons, and t-test was used for independent samples for quantitative data. Data were expressed as mean ± SD for continuous variables and numbers and percentages for categorical variables. A value of p<0.05 was considered significant. Results The mean age of the patients was 60.5 years, 70.8% were male. There were five types of tumors defined histopathologically, and the most common diagnosis was adenocarcinoma (76.9%). The most common localization of the tumor was head and neck (44.4%). Whipple surgery was performed predominantly in 69.2% of patients, and distal pancreatectomy in 29.0%. Postoperative complications were observed in more than one third (34%) of the patients. The main complications were pancreatic cyst (16.3%). In the survival analysis performed with the Kaplan-Meier test, median survival of 30.5 months, and overall survival (OS) at 1.2 and 5 years were 67.8%, 40.5%, and 16.6%, respectively. Discussion However, survival analysis results were optimistic compared to population-based studies as all patients had resectable tumors.

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Importance of Carbohydrate Antigen 19-9 Monitoring in the Management of Pancreatic Cancer

Management of Localized Pancreatic Cancer ◽

10.1007/978-3-319-98944-0_4 ◽

2019 ◽

pp. 39-45

Author(s):

Ashley N. Krepline ◽

Flavio G. Rocha ◽

Susan Tsai

Keyword(s):

Pancreatic Cancer ◽

Carbohydrate Antigen

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The early diagnostic value of combined detection of plasma miR-181b, miR-196a and miR-210 in pancreatic cancer

10.21203/rs.2.15310/v1 ◽

2019 ◽

Author(s):

Gongpan Liu ◽

Cunhua Shao ◽

Anyun Li ◽

Xiaobin Zhang ◽

Xingjun Guo ◽

...

Keyword(s):

Pancreatic Cancer ◽

Early Diagnosis ◽

Operating Characteristic ◽

Clinical Stage ◽

Diagnostic Value ◽

Carbohydrate Antigen ◽

Healthy Individuals ◽

Diagnostic Efficacy ◽

Lymph Nodes Metastasis ◽

Combined Detection

Abstract Background This study aimed to investigate the effect of combination of plasma miR-181b, miR-196a and miR-210 on early diagnosis of pancreatic cancer (PC).Methods In our study, the plasma was isolated from patients with PC and healthy individuals, respectively. The expressions of miR-181b, miR-196a and miR-210 were detected by qRT-PCR. Moreover, the level of carbohydrate antigen 199 (CA199) was measured by electrochemiluminescence (ECL) assay. Furthermore, the area under the receiver operating characteristic (ROC) curve (AUC) was used to analyze the diagnostic efficacy of miR-181b, miR-196a, miR-210 and CA199, as well as the combination of thses miRNAs in early PC patients and healthy individuals.Results The expressions of miR-181b, miR-196a and miR-210 were significantly upregulated in PC patients. In addition, the level of CA199 was also significantly upregulated in the plasma of PC patients. The expressions of miR-181b, miR-196a and miR-210 were closely associated with lymph nodes metastasis, clinical stage and vascular invasion, but had no correlation with the patient's age, gender and tumor size. Moreover, miR-181b, miR-196a and miR-210 have lower AUC than CA199 in PC patients. The combinations miR-181b + miR-196a, miR-181b + miR-210, miR-196a + miR-210 also have lower AUC than CA199 in PC patients. It is worth noting that the combinations miR-181b + miR-196a + miR-210 have higher AUC than CA199 in PC.Conclusions Our study demonstrated that the combination of plasma miR-181b, miR-196a and miR-210 had good value for PC early diagnosis.

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Can IL-2R Alpha be a Valuable Marker along with Ca 19–9 in the Diagnosis of Chronic Pancreatitis and Pancreatic Cancer?

The International Journal of Biological Markers ◽

10.1177/172460080401900304 ◽

2004 ◽

Vol 19 (3) ◽

pp. 196-202

Author(s):

B. Kayhan ◽

M. Akdoğ;an

Keyword(s):

Pancreatic Cancer ◽

Chronic Pancreatitis ◽

Interleukin 2 ◽

Carbohydrate Antigen ◽

Control Group ◽

Serum Samples ◽

Cancer Group ◽

Abdominal Symptoms ◽

Significant Difference ◽

Inflammatory Processes

Background Pancreatic cancer is characterized initially by non-specific abdominal symptoms followed by rapid tumor progression. Although chronic pancreatitis is a benign disorder, it can be one of the causative factors of pancreatic cancer. The level of the tumor marker carbohydrate antigen 19–9 (CA 19–9) in pancreatic cancer does not correlate with the stage of the neoplasm. Soluble interleukin 2 receptor (sIL-2R) is a cytokine that shows increased levels during some inflammatory processes and malignant disorders. Aim Our aim in this study was to investigate whether sIL-2Rα levels can be used in association with CA 19–9 in the early diagnosis of pancreatic cancer and chronic pancreatitis. Patients Serum samples were obtained from the blood of 21 pancreatic cancer patients without distant metastasis who were deemed inoperable, 16 chronic pancreatitis patients and 20 normal volunteers. Results We did not find any significant differences in CA 19–9 levels between normal controls and patients with chronic pancreatitis. There was a significant difference in the levels between the control group and the pancreatic cancer group (p=0.003) and between patients with chronic pancreatitis and those with pancreatic cancer (p=0.004). Although there was no significant difference in sIL-2Rα levels between the control group and the patient groups, we found a slight correlation between sIL-2Rα and CA 19–9 levels in the pancreatic cancer group (p=0.003, r=0.623) and a more marked correlation in the chronic pancreatitis group (p<0.01, r=0.751). Conclusion According to our results, sIL-2Rα alone is not a good candidate marker in the diagnosis of pancreatic cancer; it can, however, be used in association with CA 19–9 for this purpose.

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