63 HELICOBACTER PYLORI AND GALLSTONE DISEASE: DOES OPTIMIZING PREOPERATIVE DIAGNOSIS AVOID UNNECESSARY SURGICAL INTERVENTION IN PATIENTS REFERRED FOR SYMPTOMATIC GALLSTONE DISEASE?

Background. The association of gallstones withHelicobacter pylorihas been investigated but not clearly demonstrated. In this study, the presence ofH. pyloriin the gallbladder mucosa of patients with symptomatic gallstones was investigated.Method. Ninety-four consecutive patients with symptomatic gallstone disease were enrolled for the study. Gastroscopy and gastricH. pyloriurease test were done before cholecystectomy to all patients who accepted. After cholecystectomy, the gallbladder tissue was investigated in terms ofH. pyloriby urease test, Giemsa, and immunohistochemical stain.Results. Overall 35 patients (37%) gallbladder mucosa tested positive forH. pyloriwith any of the three tests. Correlation of the three tests Giemsa, IHC, and rapid urease test was significant(rs: 0590,P>0.001). Rapid urease test was positive in the gastric mucosa in 47 (58.7%) patients, and it was positive in the gallbladder mucosa in 21 patients (22%). In 15 patients both gastric and gallbladder tested positive with the urease test. There was significant correlation of rapid urease test in both of gallbladder and gastric mucosa(P=0.0001).Conclusion. Study demonstrates the presence ofH. pyloriin the gallbladders of 37% of patients with symptomatic gallstones.

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Faculty Opinions recommendation of Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery: study protocol for a randomized controlled trial (UPGRADE trial).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732370979.793550824 ◽

2018 ◽

Author(s):

Piero Portincasa

Keyword(s):

Bariatric Surgery ◽

Randomized Controlled Trial ◽

Ursodeoxycholic Acid ◽

Study Protocol ◽

Controlled Trial ◽

Gallstone Disease ◽

Randomized Controlled ◽

Symptomatic Gallstone Disease

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Quality-of-life measures in Taiwanese adults with symptomatic gallstone disease

Quality of Life Research ◽

10.1007/s11136-010-9635-3 ◽

2010 ◽

Vol 19 (6) ◽

pp. 769-773 ◽

Cited By ~ 3

Author(s):

Hen-Hui Lien ◽

Chi-Cheng Huang ◽

Pa-Chun Wang ◽

Ching-Shui Huang ◽

Ya-Hui Chen ◽

...

Keyword(s):

Quality Of Life ◽

Gallstone Disease ◽

Quality Of Life Measures ◽

Symptomatic Gallstone Disease

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Is Routine MRCP Needed in Symptomatic Gallstone Disease? - A Single Center Experience

HPB ◽

10.1016/j.hpb.2020.11.908 ◽

2021 ◽

Vol 23 ◽

pp. S356

Author(s):

T. Pareek ◽

O.L. Naganath Babu ◽

S. Rajendran ◽

R. Prabhakaran ◽

R. Rajkumar

Keyword(s):

Gallstone Disease ◽

Single Center ◽

Single Center Experience ◽

Symptomatic Gallstone Disease

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Advantages and limitations of the use of tractography and fMRI in the treatment of anaplastic glioma

Spravočnik vrača obŝej praktiki (Journal of Family Medicine) ◽

10.33920/med-10-2111-04 ◽

2021 ◽

pp. 32-42

Author(s):

Igor Aleksandrovich Medyanik ◽

Simon Quarteng Badu

Keyword(s):

Neurological Disorders ◽

Preoperative Diagnosis ◽

Surgical Intervention ◽

Complete Resection ◽

Anaplastic Glioma ◽

Neurological Deficits ◽

Neural Pathways ◽

Histological Subtype ◽

Group A ◽

Group B

The possibility of using only tractography as a preoperative diagnosis of anaplastic glioma is limited due to its inability to show the exact functional location of the tumor; therefore, the combination of tractography and fMRI seems to be a more promising complex diagnostic method. In neurooncology, complete resection without or with minimal neurological deficit is the goal of surgical intervention. The aim of the study was to investigate the advantages and limitations of the use of tractography and fMRI in the treatment of anaplastic glioma compared to standard CT or MRI. The study involved 48 patients who were divided into two groups based on the use of fMRI and tractography: group A (24 patients) and without it — group B (24 patients). The groups were compared in terms of age, sex, histological subtype of anaplastic glioma, degree of resection, postoperative complications, and dynamics of neurological disorders. The combination of fMRI and tractography is the best preoperative diagnosis, it is safe and allows localizing neural pathways, preserve them during surgery, and reduce postoperative neurological deficits.

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INFORMATIVE VALUE OF SONOELASTOGRAPHY IN THE DIFFERENTIAL DIAGNOSIS OF FOLLICULAR THYROID CANCER

Acta medica Eurasica ◽

10.47026/2413-4864-2021-4-73-78 ◽

2021 ◽

pp. 73-78

Author(s):

Lyubov A. Timofeeva ◽

Tatiana N. Aleshina ◽

Marina E. Baranova ◽

Marina A. Yusova ◽

Natalia N. Nikolaeva

Keyword(s):

Thyroid Cancer ◽

Preoperative Diagnosis ◽

Surgical Intervention ◽

Ultrasound Examination ◽

Shear Wave Elastography ◽

Diagnostic Methods ◽

Follicular Thyroid Cancer ◽

Leading Role ◽

Quantitative Characteristics ◽

Multiparametric Ultrasound

In recent years, the opportunities of radiation diagnostic methods have stepped far ahead and today they play a leading role at the stage of preoperative diagnosis of thyroid diseases. The most promising of them is multiparametric ultrasound examination, as well as sonoelastography associated with it. Strain elastography and shear wave elastography make it possible to determine the boundaries of pathological formation and quantitative characteristics of nodular stiffness, which is important when determining the boundaries of invasive tumor growth, primarily thyroid cancer, when planning an upcoming surgical intervention. The article describes a clinical case of radiation diagnosis made for follicular thyroid cancer; it shows the importance of multiparametric ultrasound, including sonoelastography, in the early detection of thyroid cancer. A timely diagnosis and a correct chosen tactics for treating follicular thyroid cancer resulted in a favorable disease outcome.

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A prospective observational study to study and correlate the clinical and microbiological profile of bile cultures in patients with symptomatic cholelithiasis

International Surgery Journal ◽

10.18203/2349-2902.isj20201870 ◽

2020 ◽

Vol 7 (5) ◽

pp. 1566

Author(s):

Ramakrishnan Shankaran ◽

Chaminda Amarasekara

Keyword(s):

Laparoscopic Cholecystectomy ◽

Gall Bladder ◽

Gallstone Disease ◽

Significant Proportion ◽

Antibiotic Sensitivity ◽

Klebsiella Species ◽

Duration Of Symptoms ◽

Symptomatic Cholelithiasis ◽

Bile Culture ◽

Symptomatic Gallstone Disease

Background: Biliary infection has been reported in a significant proportion of patients developing gallstones. Many studies have found biliary microflora in 20% to 46% patients with a post-operative infection rate of 7% to 20% in those who undergo cholecystectomy for symptomatic gallstone disease. Various antibiotics are also used empirically as prophylaxis against post-operative infection. The study was conducted in order to determine the bacteriology and to test its sensitivity to commonly used antibiotics of aspirated bile samples taken during laparoscopic cholecystectomy, and to correlate it with the clinical profile recorded in patients with symptomatic cholelithiasis.Methods: A total of 266 patients who underwent laparoscopic cholecystectomy were included in the study over a two year period. Intra operatively, bile was aspirated from gall bladder and sent for culture and antibiotic sensitivity testing.Results: 14.66% (39 out of 266) patients had positive growth with Escherichia coli most commonly isolated in 9.77% (26/266) patients, followed by the Klebsiella species in 4.89% (13 out of 266) patients. All the cultures were sensitive to amikacin and meropenem, 97.44% to imipenem, and only 43.39% were sensitive to ampicillin. A statistically significant correlation was observed between a positive bile culture with the duration of symptoms (p=0.01874) and gall bladder thickness (p<0.0001). No correlation was seen between bile culture and history of acute cholecystitis, number or size of calculi.Conclusions: The results of this study can help develop local guidelines and recommendations based on Indian data to ensure the rational use of prophylactic antibiotics in patients with symptomatic cholelithiasis.

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