INFORMATIVE VALUE OF SONOELASTOGRAPHY IN THE DIFFERENTIAL DIAGNOSIS OF FOLLICULAR THYROID CANCER

2021 ◽  
pp. 73-78
Author(s):  
Lyubov A. Timofeeva ◽  
Tatiana N. Aleshina ◽  
Marina E. Baranova ◽  
Marina A. Yusova ◽  
Natalia N. Nikolaeva
Keyword(s):  
Thyroid Cancer ◽  
Preoperative Diagnosis ◽  
Surgical Intervention ◽  
Ultrasound Examination ◽  
Shear Wave Elastography ◽  
Diagnostic Methods ◽  
Follicular Thyroid Cancer ◽  
Leading Role ◽  
Quantitative Characteristics ◽  
Multiparametric Ultrasound

In recent years, the opportunities of radiation diagnostic methods have stepped far ahead and today they play a leading role at the stage of preoperative diagnosis of thyroid diseases. The most promising of them is multiparametric ultrasound examination, as well as sonoelastography associated with it. Strain elastography and shear wave elastography make it possible to determine the boundaries of pathological formation and quantitative characteristics of nodular stiffness, which is important when determining the boundaries of invasive tumor growth, primarily thyroid cancer, when planning an upcoming surgical intervention. The article describes a clinical case of radiation diagnosis made for follicular thyroid cancer; it shows the importance of multiparametric ultrasound, including sonoelastography, in the early detection of thyroid cancer. A timely diagnosis and a correct chosen tactics for treating follicular thyroid cancer resulted in a favorable disease outcome.

EVALUATION OF PREDICTIVE CAPABILITIES OF TIRADS, EU-TIRADS, TLA_RU SYSTEMS IN THE ULTRASOUND DIAGNOSIS OF THYROID NODULAR PATHOLOGY

2021 ◽  
pp. 29-38
Author(s):  
Vladimir G. Stepanov ◽  
Lyubov A. Timofeeva ◽  
Sergey V. Alekseev ◽  
Marina A. Yusova
Keyword(s):  
Thyroid Cancer ◽  
Ultrasound Examination ◽  
Standard Procedure ◽  
Benign Tumors ◽  
Quality Test ◽  
Multivariate Statistical ◽  
Excellent Quality ◽  
Ultrasound Diagnostics ◽  
Thyroid Cancer Risk ◽  
Multiparametric Ultrasound

The aim of the study was to evaluate the prognostic capabilities of EU-TIRADS, TIRADS, TLA_RU systems in ultrasound diagnostics of thyroid nodular masses. A retrospective independent continuous blind study of ultrasound examination protocols was conducted in 665 patients, 241 patients had benign non-cancerous thyroid diseases, 86 patients had benign tumors (adenomas), 338 patients had thyroid cancer. During the preoperative examination, all patients underwent a multiparametric ultrasound examination of the neck organs according to the standard procedure, with the registration of identified thyroid nodes, with examining the prognostic capabilities of stratification systems – TIRADS, EU-TIRADS, TLA_RU. It was found that the TIRADS system has a sensitivity of 91.04%, specificity – 91.41%. Focusing on the scale of AUC values reflecting the quality of the diagnostic test, it can be stated that TIRADS is a test with excellent quality (AUC =0.972). Basing on the results of the analyzing the data obtained by the EU-TIRADS system, it was revealed that it is a high-quality test (AUC=0.826), but its predictive capabilities are worse than those of TIRADS. The original TLA_RU model has 87.5% sensitivity and 95.7% specificity. During the ROC analysis, it was found that the AUC is equal to 0.954±0.00894, which suggests that the TLA_RU model is an excellent quality test in the differential diagnosis of thyroid nodular masses. Multivariate statistical comparative analysis of thyroid imaging assessment systems (TIRADS, EU-TIRADS and TLA_RU) from the standpoint of evidence-based medicine has shown that thyroid cancer risk stratification systems based on the assessment of multiparametric ultrasound signs have great diagnostic capabilities.

scholarly journals Diagnosis and treatment of complicated Meckel’s diverticulum.

2018 ◽  
Vol 95 (11) ◽  
pp. 1013-1017 ◽  
Author(s):  
V. M. Timerbulatov ◽  
M. V. Timerbulatov ◽  
D. I. Mechdiev ◽  
Shamil V. Timerbulatov ◽  
I. S. Bikovski ◽  
...  
Keyword(s):  
Inflammatory Process ◽  
Surgical Intervention ◽  
Ultrasound Examination ◽  
Meckel’S Diverticulum ◽  
Randomized Study ◽  
Meckel's Diverticulum ◽  
Diagnostic Methods ◽  
Diagnosis And Treatment ◽  
Contrast Study ◽  
Males And Females

Meckel’s diverticulum (MD) is relatively rare, although frequent anomaly of the digestive tract, as a rule, in the event of complications or incidentally at laparotomy, laparoscopy, contrast study of the bowel. Aim - to examine the results of diagnosis and treatment of complicated forms of MD. Material and methods. It was a prospective non-randomized study of 77 patients with complicated forms of MD, including 30 adults and 47 children. The ratio of males and females in adult patients were 2,3:1, and 8,4:1 in children. The incidence of complicated forms in adults was 0,61 per 100,000 adult, 6,6 per 100,000 child population. The study was used clinical, laparotomy methods, ultrasound examination, CT, endoscopy, laparoscopy. Results. Diagnostic methods can identify complications (often diverticulitis, intestinal obstruction, peritonitis), and source-cause of complications is established by laparoscopy or laparotomy. Videolaparoscopic operations (diverticulectomy) made of 35%, the option of surgical intervention depended on the size of the diverticulum, the severity of degradation and prevalence of the inflammatory process in the wall ileum. Postoperative complications were 6,49% of patients, there were no cases mortality.

Abstract #1070 An Unusual Case of Metastatic Follicular Thyroid Cancer 40 Years After Initial Diagnosis

2018 ◽  
Vol 24 ◽  
pp. 255
Author(s):  
Lakshmi Menon ◽  
Yuanjie Mao ◽  
Sanaz Abedzadeh-Anaraki ◽  
Spyridoula Maraka
Keyword(s):  
Thyroid Cancer ◽  
Unusual Case ◽  
Initial Diagnosis ◽  
Follicular Thyroid Cancer

New markers of follicular thyroid cancer found with wide-panel next-generation sequencing

2018 ◽  
Author(s):  
Martyna Borowczyk ◽  
Ewelina Szczepanek-Parulska ◽  
Szymon Debicki ◽  
Bartlomiej Budny ◽  
Malgorzata Janicka-Jedynska ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Next Generation Sequencing ◽  
Next Generation ◽  
Follicular Thyroid Cancer ◽  
Generation Sequencing

A challenging case of progressive follicular thyroid cancer

2018 ◽  
Author(s):  
Shazia Hussain ◽  
Carmel Brennan ◽  
Nick Plowman ◽  
Kate Newbold ◽  
William Drake
Keyword(s):  
Thyroid Cancer ◽  
Follicular Thyroid Cancer

The Accuracy of ACR TI-RADS Classification of Neck Ultrasound as a First-Line Diagnostic Approach for Thyroid Neoplasms in Pediatric Patients: A Retrospective Study

2018 ◽  
Vol 5 (1) ◽  
pp. 13-23
Author(s):  
Nikolai S. Grachev ◽  
Elena V. Feoktistova ◽  
Igor N. Vorozhtsov ◽  
Natalia V. Babaskina ◽  
Ekaterina Yu. Iaremenko ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Predictive Value ◽  
Thyroid Nodules ◽  
Pediatric Patients ◽  
Thyroid Neoplasms ◽  
Diagnostic Methods ◽  
Diagnostic Approach ◽  
First Line ◽  
Neck Ultrasound

Background.Ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) is the gold standard in diagnosing the pathological nature of undetermined thyroid nodules. However, in some instances limitations and shortcomings arise, making it insufficient for determining a specific diagnosis.Objective.Our aim was to evaluate the effectiveness of ACR TI-RADS classification of neck ultrasound as a first-line diagnostic approach for thyroid neoplasms in pediatric patients.Methods.A retrospective analysis was made of FNA and US protocols in 70 patients who underwent the examination and treatment at Dmitry Rogachev National Research Center between January 2012 and August 2017. In the retrospective series 70% (49/70) of patients undergone FNA and 43% (30/70) of them undergone repeated FNA. All US protocols were interpreted according to ACR TI-RADS system by the two independent experts. The clinical judgment was assessed using the concordance test and the reliability of preoperative diagnostic methods was analized.Results.According to histologic examination protocols, benign nodules reported greater multimorbidity 29% (20/70), compared with thyroid cancer 17% (12/70), complicating FNA procedure. A statistically significant predictor of thyroid cancer with a tumor size ACR TI-RADS showed a significant advantage of ACR TI-RADS due to higher sensitivity (97.6 vs 60%), specificity (78.6 vs 53.8%), positive predictive value (87.2 vs 71.4%), and negative predictive value (95.7 vs 41.2%). Concordance on the interpreted US protocols according to ACR TI-RADS classification between two experts was high, excluding accidental coincidence.Conclusion.The data support the feasibility of US corresponding to the ACR TI-RADS classification as a first-line diagnostic approach for thyroid neoplasm reducing the number of unnecessary biopsies for thyroid nodules.

DUAL-ENERGY CT WITH XENON IN PATIENTS WITH LUNG PATHOLOGY. FIRST DATA

2018 ◽  
pp. 47-51
Author(s):  
O. E. Karpov ◽  
O. Yu. Bronov ◽  
V. M. Kitaev ◽  
P. S. Vetshev ◽  
D. A. Pikhuta ◽  
...  
Keyword(s):  
Surgical Intervention ◽  
Lung Ventilation ◽  
Dual Energy ◽  
Diagnostic Methods ◽  
Dual Energy Ct ◽  
Lung Pathology ◽  
Preoperative Preparation ◽  
Before And After ◽  
Pulmonary Pathology ◽  
Postoperative Lung Function

Routine diagnostic methods have limitations in terms of predicting the ventilation function of the lungs before and after surgery. It was decided to investigate the possibilities of dual-energy CT (DECT) using xenon in assessment of lung ventilation function.Objective: to master the methods of examination of patients with pulmonary pathology, evaluate the possibility of justifying the volume of operative intervention and prediction of postoperative lung function based on the hybrid images.Materials and methods. For the study, 12 patients with different pulmonary pathologies were selected (COPD – 5, lung cancer – 4, bronchiectasis – 3). Results. It was found that the use of DECT with xenon reflects the functional state of lung tissue.Conclusions. DECT with xenon have potential for planning surgical intervention and introducing the method into modern protocols of preoperative preparation.

Assessment of drugs increasing the reproductive function of cows of oocyte donors

2020 ◽  
pp. 122-126
Author(s):  
A. Plakhova ◽  
K. Plemyashov
Keyword(s):  
Maximum Concentration ◽  
Ultrasound Examination ◽  
Reproductive Function ◽  
Experimental Animals ◽  
Qualitative And Quantitative ◽  
Quantitative Characteristics ◽  
Oocyte Donors ◽  
Experimental Group ◽  
Qualitative And Quantitative Characteristics ◽  
Donor Cows

In these studies, a comprehensive assessment of the effect of the drugs «Carofertin» and «Hemobalance» on the reproductive function of oocyte donor cows was carried out. At the same time, the effect of these drugs on the biochemical parameters of blood serum, as well as on the concentration of progesterone, carotene in the experimental groups and the activity of the ovaries in the experimental animals was assessed. An increase in the activity of alkaline phosphatase in the first and third experimental groups was found, which amounted to 128.80 and 104.6 IU / L. There was also a decrease in the concentration of cholesterol in the experimental groups compared with the control. The maximum concentration of carotene was noted in the experimental group No. 1, which were injected with «Carofertin» subcutaneously, and in the experimental group No. 3, which were injected with «Carofertin» and «Hemobalance». The maximum concentration of progesterone was also noted in groups No. 3 and No. 1 and amounted to 21.98±3.03 and 17.01±9.68 nmol / l, respectively. In the course of ultrasound examination of the ovaries in experimental animals, a relationship was noted between the concentration of progesterone and the intensity of the blood supply of the corpus luteum on the ovaries in experimental animals. Subsequently, in one animal from each experimental group, oocytes were aspirated (OPU) twice with an interval of two weeks and their qualitative and quantitative characteristics were assessed. The maximum number of oocytes suitable for use was noted in the experimental group No. 3, which was injected with both study drugs.

Fascicular torsions of the anterior and posterior interosseous nerve in 4 cases: neuroimaging methods to improve diagnosis

2020 ◽  
Vol 132 (6) ◽  
pp. 1925-1929 ◽  
Author(s):  
Jennifer Kollmer ◽  
Paul Preisser ◽  
Martin Bendszus ◽  
Henrich Kele
Keyword(s):  
Magnetic Resonance ◽  
Surgical Intervention ◽  
Case Series ◽  
Diagnostic Methods ◽  
Posterior Interosseous Nerve ◽  
Nerve Ultrasound ◽  
Magnetic Resonance Neurography ◽  
Surgical Exploration ◽  
Hyperintense Signal ◽  
Emergency Surgical Intervention

Diagnosis of spontaneous fascicular nerve torsions is difficult and often delayed until surgical exploration is performed. This case series raises awareness of peripheral nerve torsions and will facilitate an earlier diagnosis by using nerve ultrasound (NUS) and magnetic resonance neurography (MRN). Four patients with previously ambiguous upper-extremity mononeuropathies underwent NUS and 3T MRN. Neuroimaging detected proximal torsions of the anterior and posterior interosseous nerve fascicles within median or radial nerve trunks in all patients. In NUS, most cases presented with a thickening of affected nerve fascicles, followed by an abrupt caliber decrease, leading to the pathognomonic sausage-like configuration. MRN showed T2-weighted hyperintense signal alterations of fascicles at and distal to the torsion site, and directly visualized the distorted nerves. Three patients had favorable outcomes after being transferred to emergency surgical intervention, while 1 patient with existing chronic muscle atrophy was no longer eligible for surgery. NUS and MRN are complementary diagnostic methods, and both can detect nerve torsions on a fascicular level. Neuroimaging is indispensable for diagnosing fascicular nerve torsions, and should be applied in all unclear cases of mononeuropathy to determine the diagnosis and if necessary, to guide surgical therapies, as only timely interventions enable favorable outcomes.

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