The standardized creation of a lumbar spine vertebral compression fracture in a sheep osteoporosis model induced by ovariectomy, corticosteroid therapy and calcium/phosphorus/vitamin D-deficient diet

Turkey poults were fed a vitamin D-deficient diet and examined for clinical signs and structural changes of bone and parathyroid glands. Vitamin D-deficient poults developed ricketic changes during days 10 to 14. Control poults (deficient diet plus vitamin D) did not develop rickets. In deficient poults, lengths of proliferating-prehypertrophied zones of growth plates increased significantly in the proximal tibiotarsus but were only slightly elongated in the distal tibiotarsus. Unmineralized hypertrophic chondrocyte zones increased in length rapidly in conjunction with a decrease in the length of mineralized hypertrophic degenerative zones; this occurred more rapidly in proximal than in distal tibiotarsus. Other ricketic changes included decreases in bone ash, total femoral bone ash (calcium, phosphorus, magnesium), bone length, and body weight. Plasma alkaline phosphatase was increased, calcium was normal, and phosphorus was normal or elevated. Parathyroids were hyperplastic and had foci of degeneration. Vitamin D3 metabolites 25OHD3, 1,25(OH)2D3, and 24,25(OH)2D3 were rapidly depleted. Increase in bone ash Ca/P ratios in deficient poults suggests that phosphorus may be selectively released from ricketic bone. Low 25OHD3 and 1,25(OH)2D3 of control poults early in the experiment suggests that 1,400 IU of vitamin D3/kg of feed may not be an adequate level of vitamin D3 for growing turkey poults.

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Lumbar Spine Vertebral Compression Fracture Case Diagnosis Using Machine Learning Methods on CT images

2019 4th International Conference on Pattern Recognition and Image Analysis (IPRIA) ◽

10.1109/pria.2019.8786036 ◽

2019 ◽

Author(s):

Hamid Yousefi ◽

Elham Salehi ◽

Omid Sojoodi Sheyjani ◽

Hossein Ghanaatti

Keyword(s):

Machine Learning ◽

Lumbar Spine ◽

Vertebral Compression Fracture ◽

Compression Fracture ◽

Ct Images ◽

Learning Methods ◽

Machine Learning Methods ◽

Case Diagnosis

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Effects of vitamin D supplementation on the functional outcome in patients with osteoporotic vertebral compression fracture and vitamin D deficiency

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-021-02717-7 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Sangbong Ko ◽

ChungMu Jun ◽

Junho Nam

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Functional Outcome ◽

Vertebral Compression Fracture ◽

Compression Fracture ◽

Vitamin D Supplementation ◽

Osteoporotic Vertebral Compression Fracture ◽

Low Back ◽

Fracture Union

Abstract Background In osteoporotic vertebral compression fractures, supplementation using vitamin D preparations and maintenance of blood vitamin D level within the normal range are necessary for proper fracture union, enhancement of muscle strength, and maintenance of body balance. The purpose of this study is to investigate the effects of vitamin D supplementation on blood vitamin D level, pain relief, union time, and functional outcome in patients with osteoporotic vertebral compression fracture and vitamin D deficiency. Methods One hundred thirty patients who were deficient in blood vitamin D level and had osteoporotic vertebral compression fracture were divided into supplementation group and non-supplementation group. Initially, 3 months, 6 months, and 12 months after the injury, radiographs were taken to assess fracture union, and questionnaires were evaluated to evaluate the functional outcome and quality of life. Results The mean age of the 130 patients (36 males and 94 females) was 74.75 ± 7.25 years. There were no statistically significant differences in initial severity of low back pain, functional outcome, and quality of life between the insufficient group and the deficient group (all p values were > 0.05). There was no significant time-by-group interaction between the supplementation group and the non-supplementation group (p = 0.194). In terms of SF-36 physical component score, there was no significant time-by-group interaction between the supplementation group and the non-supplementation group (p = 0.934). Conclusions Fracture union was achieved in all patients regardless of serum vitamin D level, and there were significant improvements in severity of low back pain, functional outcome, and quality of life over 12 months in patients with osteoporotic vertebral compression fracture. Short-term vitamin D supplementation of patients with osteoporotic vertebral compression fracture and deficiency of vitamin D did not result in significant differences in fracture union status, functional outcome, and quality of life between the supplementation groups and the non-supplementation groups of patients.

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Effects of Vitamin D Supplementation on the Functional Outcome in Patients With Osteoporotic Vertebral Compression Fracture and Vitamin D Deficiency

10.21203/rs.3.rs-596496/v1 ◽

2021 ◽

Author(s):

Sangbong Ko ◽

ChungMu Jun ◽

Junho Nam

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Functional Outcome ◽

Vertebral Compression Fracture ◽

Compression Fracture ◽

Vitamin D Supplementation ◽

Osteoporotic Vertebral Compression Fracture ◽

Low Back ◽

Fracture Union

Abstract BackgroundIn osteoporotic vertebral compression fractures, supplementation using vitamin D preparations and maintenance of blood vitamin D level within the normal range are necessary for proper fracture union, enhancement of muscle strength, and maintenance of body balance. The purpose of this study is to investigate the effects of vitamin D supplementation on blood vitamin D level, pain relief, union time, and functional outcome in patients with osteoporotic vertebral compression fracture and vitamin D deficiency.Methods130 patients who deficient blood vitamin D level and had osteoporotic vertebral compression fracture were divided into a supplementation group and non-supplementation group. At initial, 3 months, 6 months and 12 months after the injury, radiographs were taken to assess fracture union, and questionnaire were evaluated to evaluate the functional outcome and quality of life.ResultsThe mean age of the 130 patients (36 males and 94 females) was 74.75 ± 7.25 years. There were no statistically significant differences in initial severity of low back pain, functional outcome, and quality of life between the insufficient group and deficient group (all p values were >0.05). There was no significant time-by-group interaction between the supplementation group and non-supplementation group (p = 0.194). In terms of SF-36 physical component score, there was no significant time-by-group interaction between the supplementation group and non-supplementation group (p = 0.934).ConclusionsFracture union was achieved in all patients regardless of serum vitamin D level, and there were significant improvements in severity of low back pain, functional outcome, and quality of life over 12 months in patients with osteoporotic vertebral compression fracture. Short-term vitamin D supplementation of patients with osteoporotic vertebral compression fracture and deficiency of vitamin D did not result in significant differences in fracture union status, functional outcome, and quality of life between the supplementation groups and non-supplementation groups of patients

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Nocturnal vertebral compression fracture. A presenting feature of unrecognized epileptic seizures

Archives of Family Medicine ◽

10.1001/archfami.6.2.185 ◽

1997 ◽

Vol 6 (2) ◽

pp. 185-187 ◽

Cited By ~ 13

Author(s):

A. G. Aboukasm

Keyword(s):

Vertebral Compression Fracture ◽

Compression Fracture ◽

Epileptic Seizures

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Status of Serum calcium, phosphorus and Vitamin D

International Journal of Scientific Research ◽

10.15373/22778179/july2013/111 ◽

2012 ◽

Vol 2 (7) ◽

pp. 329-330

Author(s):

Saira Baloch ◽

◽

Bikha Ram Devrajani ◽

Aneela Atta-ur-Rahman

Keyword(s):

Vitamin D ◽

Serum Calcium ◽

Calcium Phosphorus

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Vitamin D Provision in High-Yield Dairy Cows During the Winter Housing Period

Agricultural science and practice ◽

10.15407/agrisp1.01.042 ◽

2014 ◽

Vol 1 (1) ◽

pp. 42-46

Author(s):

L. Yuskiv ◽

V. Vlizlo

Keyword(s):

Vitamin D ◽

Alkaline Phosphatase Level ◽

Mineral Metabolism ◽

Physiological State ◽

Blood Parameters ◽

Postnatal Period ◽

High Yield ◽

Oral Supplementation ◽

Calcium Phosphorus ◽

Vitamin D 3

Aim. To investigate the vitamin D status in highly productive cows during winter housing period and effect of cholecalciferol by various ways of vitamin D 3 injection to cows in last days of gestation and after calving. Methods. Enzyme-linked immunoassay, spectrophotometry. Results. It has been stated that intramuscular injection of cholecalciferol into cows caused increase of the vitamin D 3 active metabolite – 25-OHD 3 , calcium, phosphorus and magnesium levels together with decrease of alkaline phosphatase level in pre- and post-natal periods. Oral supplementation makes little infl uence on the studied blood parameters of cows. Conclusions. Extrabuccal administration and oral supplementation of cholecalciferol in winter housing period to high-yield cows in the last days of gestation and after calving is accompanied by increased levels of its metabolites and their effect on mineral metabolism in the postnatal period. The nature of these changes depends on the mode of vitamin D administration and the physiological state of the cows.

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