Oocyte retrieval rate through repeated controlled ovarian hyperstimulation cycles in donors

The reports on how to stimulate the ovaries for oocyte retrieval in good prognosis patients are contradictory and often favor one type of controlled ovarian hyperstimulation (COH). For this reason, we retrospectively analyzed data from IVF/ICSI cycles carried out at our IVF Unit in good prognosis patients (aged <38 years, first and second attempts of IVF/ICSI, more than 3 oocytes retrieved) to elucidate which type of COH is optimal at our condition. The included patients were undergoing COH using GnRH agonist, GnRH antagonist or GnRH antagonist mild protocol in combination with gonadotrophins. We found significant differences in the average number of retrieved oocytes, immature oocytes, fertilized oocytes, embryos, transferred embryos, embryos frozen per cycle, and cycles with embryo freezing between studied COH protocols. Although there were no differences in live birth rate (LBR), miscarriages, and ectopic pregnancies between compared protocols, pregnancy rate was significantly higher in GnRH antagonist mild protocol in comparison with both GnRH antagonist and GnRH agonist protocols and cumulative LBR per cycle was significantly higher in GnRH antagonist mild protocol in comparison to GnRH agonist protocol. Our data show that GnRH antagonist mild protocol of COH could be the best method of choice in good prognosis patients.

Download Full-text

Comparison of Dydrogesterone and Medroxyprogesterone in the Progestin-Primed Ovarian Stimulation Protocol for Patients With Poor Ovarian Response

Frontiers in Endocrinology ◽

10.3389/fendo.2021.708704 ◽

2021 ◽

Vol 12 ◽

Author(s):

Junwei Zhang ◽

Mingze Du ◽

Zhen Li ◽

Wenxia Liu ◽

Bingnan Ren ◽

...

Keyword(s):

Oocyte Retrieval ◽

Ovarian Response ◽

Fertilization Rate ◽

Poor Ovarian Response ◽

Retrieval Rate ◽

Biochemical Pregnancy ◽

Cancellation Rate ◽

Baseline Characteristics ◽

Viable Embryo ◽

Oocyte Retrieval Rate

ObjectiveTo compare the clinical outcomes of dydrogesterone (DYG) and medroxyprogesterone (MPA) in the progestin-primed ovarian stimulation (PPOS) protocol for patients with poor ovarian response (POR).Patients and MethodsThis was a retrospective cohort study. Women with POR who underwent IVF/ICSI at the Reproductive Center of Third Affiliated Hospital of Zhengzhou University between January 2020 and January 2021 were included. The primary outcome measure of our study was the number of oocytes retrieved. The secondary outcome measures in the present study were the number of 2PN, number of available embryos, oocyte retrieval rate, fertilization rate, viable embryo rate per oocyte retrieved, cancellation rate and pregnancy outcomes of the first embryo transfer cycle, including the biochemical pregnancy, clinical pregnancy and miscarriage rates.ResultsIn total, 118 women underwent hMG +DYG protocols, and 692 women who underwent hMG +MPA met the Bologna criteria for POR. After baseline characteristics were balanced using the PSM model, 118 hMG +DYG protocols were matched to 118 hMG +MPA protocols, and the baseline characteristics were comparable between the two groups. The numbers of oocytes retrieved, 2PN, and available embryos and the oocyte retrieval rate, fertilization rate, viable embryo rate per oocyte retrieved and cancellation rate of the hMG+DYG and hMG+MPA protocols were comparable. Altogether, 66 women in the hMG+DYG group and 87 women in the hMG+MPA group underwent first embryo transfers. In the hMG+DYG group, 81.8% (54/66) of the patients underwent cleavage embryo transfers; similarly, 79.3% (69/87) of patients in the hMG+MPA group had cleavage embryo transfers (P=0.70).The biochemical pregnancy rate of the hMG+DYG group was 42.4%, and this was comparable to the rate in the hMG+DYG group, at 34.5% (P=0.32). The clinical pregnancy rates were similar between the two groups (36.4% vs. 31.0%, P=0.49), and there was no significant difference in the rate of miscarriage between the two groups (12.5% vs. 29.6%, P=0.14).ConclusionFor women with POR, the clinical outcome of the hMG + DYG group was similar to that of the hMG + MPA group, indicating that both combinations can be useful options for PPOS protocols.

Download Full-text

Is the time interval between HCG administration and oocyte retrieval associated with oocyte retrieval rate?

Reproductive BioMedicine Online ◽

10.1016/j.rbmo.2015.08.005 ◽

2015 ◽

Vol 31 (5) ◽

pp. 625-632 ◽

Cited By ~ 4

Author(s):

Julia K. Bosdou ◽

Efstratios M. Kolibianakis ◽

Christos A. Venetis ◽

Leonidas Zepiridis ◽

Katerina Chatzimeletiou ◽

...

Keyword(s):

Oocyte Retrieval ◽

Time Interval ◽

Retrieval Rate ◽

Oocyte Retrieval Rate

Download Full-text

Analyzing the risk factors for a diminished oocyte retrieval rate under controlled ovarian stimulation

Reproductive Medicine and Biology ◽

10.1002/rmb2.12004 ◽

2016 ◽

Vol 16 (1) ◽

pp. 40-44 ◽

Cited By ~ 4

Author(s):

Mayumi Nakamura ◽

Yoshiki Yamashita ◽

Atsushi Hayashi ◽

Natsuho Saito ◽

Masae Yu ◽

...

Keyword(s):

Risk Factors ◽

Ovarian Stimulation ◽

Oocyte Retrieval ◽

Controlled Ovarian Stimulation ◽

Retrieval Rate ◽

Oocyte Retrieval Rate

Download Full-text

Age and Serum AMH and FSH Levels as Predictors of the Number of Oocytes Retrieved from Chromosomal Translocation Carriers after Controlled Ovarian Hyperstimulation: Applicability and Limitations

Genes ◽

10.3390/genes12010018 ◽

2020 ◽

Vol 12 (1) ◽

pp. 18

Author(s):

Yulia V. Shilenkova ◽

Anna A. Pendina ◽

Irina D. Mekina ◽

Olga A. Efimova ◽

Evgeniia M. Komarova ◽

...

Keyword(s):

Robertsonian Translocation ◽

Chromosomal Translocation ◽

Oocyte Retrieval ◽

Controlled Ovarian Hyperstimulation ◽

Median Number ◽

Chromosomal Translocations ◽

Ovarian Hyperstimulation ◽

Younger Age ◽

Positive Correlations ◽

The Impact

We studied the impact of age and the serum anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus–oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstimulation (COH). The number of COCs retrieved after COH was retrospectively analyzed in female translocation carriers and 46,XX partners of male translocation carriers from 100 couples. The median number of COCs varied from nine to 16 and did not differ among subgroups of women categorized by age, presence and type of a translocation. The number of COCs correlated negatively with the woman’s age in both the reciprocal and the Robertsonian translocation carriers, while in 46,XX women no correlation was detected. The number of COCs did not differ between the reciprocal and the Robertsonian translocation carriers aged either <35 or ≥35 years. In translocation carriers, the number of COCs correlated with the serum AMH level only in the younger-age subgroups; the correlation was strong positive in reciprocal and moderate positive in Robertsonian translocation carriers. The 46,XX women aged both <35 and ≥35 years showed similar moderate positive correlations. Across all subgroups, the number of COCs correlated moderately negatively with the serum FSH level only in Robertsonian translocation carriers aged <35 years. Our results suggest that chromosomal translocations per se do not increase the risk of poor oocyte retrieval outcome after COH. In translocation carriers, oocyte retrieval outcome depends to a large extent on their age. The serum AMH level strongly predicts oocyte retrieval outcomes only in young reciprocal translocation carriers, while the serum FSH level has a moderate predictive value in young Robertsonian translocation carriers.

Download Full-text