scholarly journals Differential Gene Expression of Transcription Factor LZIP during Mouse Car-diac Development

1997 ◽  
Vol 73 ◽  
pp. 73
Author(s):  
Masaaki Hayashi ◽  
Hiroyasu Inada ◽  
Toshio Tanaka
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Differential Gene Expression ◽  
Differential Gene

Early genetic responses in rat vascular tissue after simulated diving

2012 ◽  
Vol 44 (24) ◽  
pp. 1201-1207 ◽  
Author(s):  
Ingrid Eftedal ◽  
Arve Jørgensen ◽  
Ragnhild Røsbjørgen ◽  
Arnar Flatberg ◽  
Alf O. Brubakk
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Plasminogen Activator ◽  
Differential Gene Expression ◽  
Vascular Function ◽  
Plasminogen Activator Inhibitor ◽  
Fine Tuning ◽  
Plasminogen Activator Inhibitor 1 ◽  
Differential Gene ◽  
Activator Inhibitor

Diving causes a transient reduction of vascular function, but the mechanisms behind this are largely unknown. The aim of this study was therefore to analyze genetic reactions that may be involved in acute changes of vascular function in divers. Rats were exposed to 709 kPa of hyperbaric air (149 kPa Po2) for 50 min followed by postdive monitoring of vascular bubble formation and full genome microarray analysis of the aorta from diving rats ( n = 8) and unexposed controls ( n = 9). Upregulation of 23 genes was observed 1 h after simulated diving. The differential gene expression was characteristic of cellular responses to oxidative stress, with functions of upregulated genes including activation and fine-tuning of stress-responsive transcription, cytokine/cytokine receptor signaling, molecular chaperoning, and coagulation. By qRT-PCR, we verified increased transcription of neuron-derived orphan receptor-1 ( Nr4a3), plasminogen activator inhibitor 1 ( Serpine1), cytokine TWEAK receptor FN14 ( Tnfrsf12a), transcription factor class E basic helix-loop-helix protein 40 ( Bhlhe40), and adrenomedullin ( Adm). Hypoxia-inducible transcription factor HIF1 subunit HIF1-α was stabilized in the aorta 1 h after diving, and after 4 h there was a fivefold increase in total protein levels of the procoagulant plasminogen activator inhibitor 1 (PAI1) in blood plasma from diving rats. The study did not have sufficient power for individual assessment of effects of hyperoxia and decompression-induced bubbles on postdive gene expression. However, differential gene expression in rats without venous bubbles was similar to that of all the diving rats, indicating that elevated Po2 instigated the observed genetic reactions.

scholarly journals EDGEdb: a transcription factor-DNA Interaction database for the analysis of C. elegans differential gene expression

BMC Genomics ◽  
2007 ◽  
Vol 8 (1) ◽  
Author(s):  
M Inmaculada Barrasa ◽  
Philippe Vaglio ◽  
Fabien Cavasino ◽  
Laurent Jacotot ◽  
Albertha JM Walhout
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Differential Gene Expression ◽  
Dna Interaction ◽  
C Elegans ◽  
Interaction Database ◽  
Differential Gene

scholarly journals Alterations in gene expression in the spinal cord of mice lacking Nfix

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Elise Matuzelski ◽  
Alexandra Essebier ◽  
Lachlan Harris ◽  
Richard M. Gronostajski ◽  
Tracey J. Harvey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Transcription Factor ◽  
Differential Gene Expression ◽  
Cell Biology ◽  
Wild Type ◽  
Spinal Cord Development ◽  
Differential Gene ◽  
Developing Mouse Brain

Abstract Objective Nuclear Factor One X (NFIX) is a transcription factor expressed by neural stem cells within the developing mouse brain and spinal cord. In order to characterise the pathways by which NFIX may regulate neural stem cell biology within the developing mouse spinal cord, we performed an microarray-based transcriptomic analysis of the spinal cord of embryonic day (E)14.5 Nfix−/− mice in comparison to wild-type controls. Data description Using microarray and differential gene expression analyses, we were able to identify differentially expressed genes in the spinal cords of E14.5 Nfix−/− mice compared to wild-type controls. We performed microarray-based sequencing on spinal cords from n = 3 E14.5 Nfix−/− mice and n = 3 E14.5 Nfix+/+ mice. Differential gene expression analysis, using a false discovery rate (FDR) p-value of p < 0.05, and a fold change cut-off for differential expression of >  ± 1.5, revealed 1351 differentially regulated genes in the spinal cord of Nfix−/− mice. Of these, 828 were upregulated, and 523 were downregulated. This resource provides a tool to interrogate the role of this transcription factor in spinal cord development.

scholarly journals Same same but different: Cluster architecture variation in five ‘Pinot Noir’ clonal selection lines correlates with differential expression of three transcription factors and further growth related genes

2020 ◽  
Author(s):  
Robert Richter ◽  
Susanne Rossmann ◽  
Doreen Gabriel ◽  
Reinhard Töpfer ◽  
Klaus Theres ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Differential Gene Expression ◽  
Fungal Infections ◽  
Clonal Selection ◽  
Pinot Noir ◽  
Cellular Growth ◽  
Wine Production ◽  
Cluster Architecture ◽  
Differential Gene

AbstractGrapevine (Vitis vinifera L.) is an economically important crop that needs to comply with high quality standards for fruit, juice and wine production. Intense plant protection is required to avoid losses caused by fungal infections. Grapevine cultivars with loose cluster architecture enable to reduce protective chemical treatments due to their enhanced resilience against fungal infections such as Botrytis cinerea induced grey mold. A recent study identified transcription factor gene VvGRF4 as determinant of inflorescence structure in exemplary samples of loose and compact quasi-isogenic ‘Pinot Noir’ clones. Here, we extended the analysis to 12 differently clustered ‘Pinot Noir’ clones originating from five different clonal selection programs. Differential gene expression of these clones was studied in three different locations over three seasons in demonstrative vineyards. Two phenotypically contrasting clones were grown at all three locations and served for standardization of downstream analyses. Differential gene expression data were correlated to the phenotypic variation of cluster architecture sub-traits. A consistent differential gene expression of VvGRF4 in relation to loose clusters was verified over the different environments and in the extended set of ‘Pinot Noir’ clones. In addition, 14 more genes with consistent expression differences between loosely and compactly clustered clones independent from season and location were identified. These genes show annotations related to cellular growth, cell wall extension, cell division and auxin metabolism. They include two more transcription factor genes.

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