Investigation of a novel defect in patients with familial hypercholesterolaemia (FH): Identification of a protein that binds to the cytoplasmic tail of the low density lipoprotein (LDL) receptor

2000 ◽  
Vol 151 (1) ◽  
pp. 242-243
Author(s):  
J. Burden ◽  
E. Eden ◽  
X-M. Sun ◽  
A. Soutar
Keyword(s):  
Familial Hypercholesterolaemia ◽  
Low Density Lipoprotein ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Cytoplasmic Tail ◽  
Low Density

Identification of a deletion in the low density lipoprotein (LDL) receptor gene in a patient with familial hypercholesterolaemia

1985 ◽  
Vol 71 (1) ◽  
pp. 75-78 ◽  
Author(s):  
B. Horsthemke ◽  
Anna M. Kessling ◽  
Mary Seed ◽  
V. Wynn ◽  
R. Williamson ◽  
...  
Keyword(s):  
Familial Hypercholesterolaemia ◽  
Receptor Gene ◽  
Low Density Lipoprotein ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Low Density

scholarly journals Interaction of 4-hydroxynonenal-modified low-density lipoproteins with the fibroblast apolipoprotein B/E receptor

1986 ◽  
Vol 234 (1) ◽  
pp. 245-248 ◽  
Author(s):  
W Jessup ◽  
G Jurgens ◽  
J Lang ◽  
H Esterbauer ◽  
R T Dean
Keyword(s):  
Apolipoprotein B ◽  
Negative Charge ◽  
Low Density Lipoprotein ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipid Peroxidation Product ◽  
Modified Low Density Lipoproteins ◽  
Peroxidation Product

The incorporation of the lipid peroxidation product 4-hydroxynonenal into low-density lipoprotein (LDL) increases the negative charge of the particle, and decreases its affinity for the fibroblast LDL receptor. It is suggested that this modification may occur in vivo, and might promote atherogenesis.

Sign in / Sign up

Export Citation Format

Share Document