W01.45 Interaction between autologous human plaque-derived vascular smooth muscle cells, type 1 NKT and CD4+ T cells: Implication for atherosclerosis disease progression

2004 ◽  
Vol 5 (1) ◽  
pp. 10-11
Author(s):  
W CHAN
Keyword(s):  
T Cells ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Disease Progression ◽  
Vascular Smooth Muscle Cells ◽  
Cd4 T Cells ◽  
Muscle Cells

scholarly journals TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque

2006 ◽  
Vol 203 (1) ◽  
pp. 239-250 ◽  
Author(s):  
Kayoko Sato ◽  
Alexander Niessner ◽  
Stephen L. Kopecky ◽  
Robert L. Frye ◽  
Jörg J. Goronzy ◽  
...  
Keyword(s):  
T Cells ◽  
Smooth Muscle ◽  
T Cell ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Atherosclerotic Plaque ◽  
Cd4 T Cells ◽  
Muscle Cells ◽  
Immunodeficient Mice

Acute coronary syndromes (ACS) are precipitated by a rupture of the atherosclerotic plaque, often at the site of T cell and macrophage infiltration. Here, we show that plaque-infiltrating CD4 T cells effectively kill vascular smooth muscle cells (VSMC). VSMCs sensitive to T cell–mediated killing express the death receptor DR5 (TNF-related apoptosis-inducing ligand [TRAIL] receptor 2), and anti-TRAIL and anti-DR5 antibodies block T cell–mediated apoptosis. CD4 T cells that express TRAIL upon stimulation are expanded in patients with ACS and more effectively induce VSMC apoptosis. Adoptive transfer of plaque-derived CD4 T cells into immunodeficient mice that are engrafted with human atherosclerotic plaque results in apoptosis of VSMCs, which was prevented by coadministration of anti-TRAIL antibody. These data identify that the death pathway is triggered by TRAIL-producing CD4 T cells as a direct mechanism of VSMC apoptosis, a process which may lead to plaque destabilization.

scholarly journals Nuclear factor of activated T cells mediates oxidised LDL-induced calcification of vascular smooth muscle cells

Diabetologia ◽  
2011 ◽  
Vol 54 (10) ◽  
pp. 2690-2701 ◽  
Author(s):  
C. Goettsch ◽  
M. Rauner ◽  
C. Hamann ◽  
K. Sinningen ◽  
U. Hempel ◽  
...  
Keyword(s):  
T Cells ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Nuclear Factor ◽  
Activated T Cells ◽  
Oxidised Ldl

scholarly journals EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells

2010 ◽  
Vol 49 (6) ◽  
pp. 1012-1021 ◽  
Author(s):  
Gyun Jee Song ◽  
Stacey Barrick ◽  
Kristen L. Leslie ◽  
Brian Sicari ◽  
Nathalie M. Fiaschi-Taesch ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Parathyroid Hormone ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mitogenic Action
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