scholarly journals 3-Deazaadenosine. S-adenosylhomocysteine hydrolase-independent mechanism of action in mouse lymphocytes.

1984 ◽  
Vol 259 (2) ◽  
pp. 1122-1126
Author(s):  
T P Zimmerman ◽  
M Iannone ◽  
G Wolberg
Keyword(s):  
Mechanism Of Action ◽  
Adenosylhomocysteine Hydrolase ◽  
Independent Mechanism ◽  
Mouse Lymphocytes

scholarly journals Design and synthesis of anticancer 1-hydroxynaphthalene-2-carboxanilides with a p53 independent mechanism of action

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ewelina Spaczyńska ◽  
Anna Mrozek-Wilczkiewicz ◽  
Katarzyna Malarz ◽  
Jiri Kos ◽  
Tomas Gonec ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Design And Synthesis ◽  
Independent Mechanism

scholarly journals Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142678 ◽  
Author(s):  
Anna Mrozek-Wilczkiewicz ◽  
Ewelina Spaczynska ◽  
Katarzyna Malarz ◽  
Wioleta Cieslik ◽  
Marzena Rams-Baron ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Design Synthesis ◽  
Independent Mechanism

scholarly journals Emi2-mediated Inhibition of E2-substrate Ubiquitin Transfer by the Anaphase-promoting Complex/Cyclosome through a D-Box–independent Mechanism

2010 ◽  
Vol 21 (15) ◽  
pp. 2589-2597 ◽  
Author(s):  
Wanli Tang ◽  
Judy Qiju Wu ◽  
Chen Chen ◽  
Chih-Sheng Yang ◽  
Jessie Yanxiang Guo ◽  
...  
Keyword(s):  
Oocyte Maturation ◽  
Mechanism Of Action ◽  
Substrate Binding ◽  
Zinc Binding ◽  
Anaphase Promoting Complex ◽  
Binding Region ◽  
Independent Mechanism ◽  
Interesting Possibility ◽  
Vertebrate Eggs

Vertebrate eggs are arrested at Metaphase II by Emi2, the meiotic anaphase-promoting complex/cyclosome (APC/C) inhibitor. Although the importance of Emi2 during oocyte maturation has been widely recognized and its regulation extensively studied, its mechanism of action remained elusive. Many APC/C inhibitors have been reported to act as pseudosubstrates, inhibiting the APC/C by preventing substrate binding. Here we show that a previously identified zinc-binding region is critical for the function of Emi2, whereas the D-box is largely dispensable. We further demonstrate that instead of acting through a “pseudosubstrate” mechanism as previously hypothesized, Emi2 can inhibit Cdc20-dependent activation of the APC/C substoichiometrically, blocking ubiquitin transfer from the ubiquitin-charged E2 to the substrate. These findings provide a novel mechanism of APC/C inhibition wherein the final step of ubiquitin transfer is targeted and raise the interesting possibility that APC/C is inhibited by Emi2 in a catalytic manner.

The synthesis and anticancer activity of 2-styrylquinoline derivatives. A p53 independent mechanism of action

2019 ◽  
Vol 177 ◽  
pp. 338-349 ◽  
Author(s):  
Anna Mrozek-Wilczkiewicz ◽  
Michał Kuczak ◽  
Katarzyna Malarz ◽  
Wioleta Cieślik ◽  
Ewelina Spaczyńska ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Mechanism Of Action ◽  
Independent Mechanism

scholarly journals MF59 and Pam3CSK4 Boost Adaptive Responses to Influenza Subunit Vaccine through an IFN Type I-Independent Mechanism of Action

2012 ◽  
Vol 188 (7) ◽  
pp. 3088-3098 ◽  
Author(s):  
Elena Caproni ◽  
Elaine Tritto ◽  
Mario Cortese ◽  
Alessandro Muzzi ◽  
Flaviana Mosca ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Subunit Vaccine ◽  
Type I ◽  
Adaptive Responses ◽  
Independent Mechanism

Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action

1996 ◽  
Vol 7 (4) ◽  
pp. 422-429 ◽  
Author(s):  
Jan Karlson ◽  
Anna-Karin Borg-Karlson ◽  
Rikard Unelius ◽  
Maria C Shoshan ◽  
Nils Wilking ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Mechanism Of Action ◽  
Tumor Cell Growth ◽  
Independent Mechanism
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