scholarly journals THE CHEMICAL NATURE AND MODE OF ACTION OF PANCREATIC CARBOXYPEPTIDASE

1949 ◽  
Vol 179 (2) ◽  
pp. 803-813
Author(s):  
Emil L. Smith ◽  
H.The. Hanson
Keyword(s):  
Mode Of Action ◽  
Chemical Nature

scholarly journals Cucurbitacins and its Anticancer property: A Review

2019 ◽  
pp. 17-23
Author(s):  
Ashmi Samuel
Keyword(s):  
Cancer Research ◽  
Pharmacological Activity ◽  
Mode Of Action ◽  
Chemical Nature ◽  
Molecular Targets ◽  
Diverse Group ◽  
Property A ◽  
Medicinal Compound ◽  
Plant Families

Cucurbitacins which are structurally unlike triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological activity. This diverse group of compounds may substantiate to be important lead molecules for the treatment of cancer. Research focused on this unattended medicinal compound can prove the significance and explore the hidden potential to cure various diseases. These compounds show their proposed mode of action, probable molecular targets and have future aspects of their use as a medicinal agent. This review is aimed to provide the chemical nature and medicinal property of cucurbitacins.

Mode of Action, Localization of Production, Chemical Nature, and Activity of Sorgoleone: A Potent PSII Inhibitor in Sorghum spp. Root Exudates1

2001 ◽  
Vol 15 (4) ◽  
pp. 813-825 ◽  
Author(s):  
MARK A. CZARNOTA ◽  
REX N. PAUL ◽  
FRANCK E. DAYAN ◽  
CHANDRASHEKHAR I. NIMBAL ◽  
LESLIE A. WESTON
Keyword(s):  
Mode Of Action ◽  
Chemical Nature ◽  
Action Localization

scholarly journals Wilhelm Siegmund Feldberg, C. B. E. 19 November 1900—23 October 1993

1997 ◽  
Vol 43 ◽  
pp. 145-170 ◽  
Author(s):  
G. W. Bisset ◽  
T. V. P. Bliss
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Synaptic Transmission ◽  
20Th Century ◽  
Mode Of Action ◽  
Experimental Approach ◽  
Chemical Nature ◽  
Working Life ◽  
The Central Nervous System ◽  
The Brain

Wilhelm Siegmund Feldberg, one of the greatest neuropharmacologists of the 20th century, was born in Hamburg on 19 November 1900. During a working life of 65 years, he published over 350 papers. His early work in Berlin on the pharmacology of histamine and acetylcholine was followed in the 1930s by his fundamental work with Dale, which finally established the chemical nature of synaptic transmission in the peripheral nervous system. In later years he turned to the central nervous system, introducing a new and widely adopted experimental approach to elucidate the site and mode of action of drugs in the brain.

Chemical Nature and Mode of Action of a Toxin from Pandorina Morum

1981 ◽  
pp. 231-241
Author(s):  
G. M. L. Patterson ◽  
D. O. Harris ◽  
W. S. Cohen
Keyword(s):  
Mode Of Action ◽  
Chemical Nature ◽  
Pandorina Morum

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

Release of Neurosecretion in the Crayfish Sinus Gland

1968 ◽  
Vol 26 ◽  
pp. 150-151
Author(s):  
Richard R. Shivers
Keyword(s):  
Chemical Nature ◽  
Storage Site ◽  
Neurosecretory Granules ◽  
Sinus Gland ◽  
Diameter Class ◽  
Dense Membrane ◽  
Neurohemal Organ ◽  
Dense Vesicles

The sinus gland is a neurohemal organ located in the crayfish eyestalk and represents a storage site for neurohormones prior to their release into the circulation. The sinus gland contains 3 classes of dense, membrane-limited granules: 1) granules measuring less than 1000 Å in diameter, 2) granules measuring 1100-1400 Å in diameter, and 3) granules measuring 1500-2000 Å in diameter. Class 3 granules are the most electron-dense of the granules found in the sinus gland, while class 2 granules are the most abundant. Generally, all granules appear to undergo similar changes during release.Release of neurosecretory granules may be initiated by a preliminary fragmentation of the “parent granule” into smaller, less dense vesicles which measure about 350 Å in diameter (V, Figs. 1-3). A decrease in density of the granules prior to their fragmentation has been observed and may reflect a change in the chemical nature of the granule contents.

Freeze-fracture cytochemistry: A goal set by Russell Steere in 1957

1993 ◽  
Vol 51 ◽  
pp. 60-61
Author(s):  
Nicholas J Severs
Keyword(s):  
Chemical Nature ◽  
Biological Systems ◽  
Freeze Fracture ◽  
Structural Components ◽  
Major Goal ◽  
Membrane Biology ◽  
Routine Application ◽  
The Future ◽  
Freeze Etching

In his pioneering demonstration of the potential of freeze-etching in biological systems, Russell Steere assessed the future promise and limitations of the technique with remarkable foresight. Item 2 in his list of inherent difficulties as they then stood stated “The chemical nature of the objects seen in the replica cannot be determined”. This defined a major goal for practitioners of freeze-fracture which, for more than a decade, seemed unattainable. It was not until the introduction of the label-fracture-etch technique in the early 1970s that the mould was broken, and not until the following decade that the full scope of modern freeze-fracture cytochemistry took shape. The culmination of these developments in the 1990s now equips the researcher with a set of effective techniques for routine application in cell and membrane biology.Freeze-fracture cytochemical techniques are all designed to provide information on the chemical nature of structural components revealed by freeze-fracture, but differ in how this is achieved, in precisely what type of information is obtained, and in which types of specimen can be studied.

Sign in / Sign up

Export Citation Format

Share Document