Cucurbitacins and its Anticancer property: A Review

Himalayan Journal of Health Sciences ◽

10.22270/hjhs.v4i4.46 ◽

2019 ◽

pp. 17-23

Author(s):

Ashmi Samuel

Keyword(s):

Cancer Research ◽

Pharmacological Activity ◽

Mode Of Action ◽

Chemical Nature ◽

Molecular Targets ◽

Diverse Group ◽

Property A ◽

Medicinal Compound ◽

Plant Families

Cucurbitacins which are structurally unlike triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological activity. This diverse group of compounds may substantiate to be important lead molecules for the treatment of cancer. Research focused on this unattended medicinal compound can prove the significance and explore the hidden potential to cure various diseases. These compounds show their proposed mode of action, probable molecular targets and have future aspects of their use as a medicinal agent. This review is aimed to provide the chemical nature and medicinal property of cucurbitacins.

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Assessing the Molecular Targets and Mode of Action of Furanone C-30 on Pseudomonas aeruginosa Quorum Sensing

Molecules ◽

10.3390/molecules26061620 ◽

2021 ◽

Vol 26 (6) ◽

pp. 1620

Author(s):

Victor Markus ◽

Karina Golberg ◽

Kerem Teralı ◽

Nazmi Ozer ◽

Esti Kramarsky-Winter ◽

...

Keyword(s):

Pseudomonas Aeruginosa ◽

Antibiotic Resistance ◽

Quorum Sensing ◽

Conformational Changes ◽

Mode Of Action ◽

Pathogenic Bacteria ◽

Molecular Targets ◽

Resistant Bacteria ◽

Public Healthcare ◽

C 30

Quorum sensing (QS), a sophisticated system of bacterial communication that depends on population density, is employed by many pathogenic bacteria to regulate virulence. In view of the current reality of antibiotic resistance, it is expected that interfering with QS can address bacterial pathogenicity without stimulating the incidence of resistance. Thus, harnessing QS inhibitors has been considered a promising approach to overriding bacterial infections and combating antibiotic resistance that has become a major threat to public healthcare around the globe. Pseudomonas aeruginosa is one of the most frequent multidrug-resistant bacteria that utilize QS to control virulence. Many natural compounds, including furanones, have demonstrated strong inhibitory effects on several pathogens via blocking or attenuating QS. While the natural furanones show no activity against P. aeruginosa, furanone C-30, a brominated derivative of natural furanone compounds, has been reported to be a potent inhibitor of the QS system of the notorious opportunistic pathogen. In the present study, we assess the molecular targets and mode of action of furanone C-30 on P. aeruginosa QS system. Our results suggest that furanone C-30 binds to LasR at the ligand-binding site but fails to establish interactions with the residues crucial for the protein’s productive conformational changes and folding, thus rendering the protein dysfunctional. We also show that furanone C-30 inhibits RhlR, independent of LasR, suggesting a complex mechanism for the agent beyond what is known to date.

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ANTITHIAMINS OF PLANT ORIGIN: THEIR CHEMICAL NATURE AND MODE OF ACTION

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1982.tb31192.x ◽

1982 ◽

Vol 378 (1 Thiamin) ◽

pp. 137-145 ◽

Cited By ~ 23

Author(s):

Doris M. Hilker ◽

J. C. Somogyi

Keyword(s):

Mode Of Action ◽

Chemical Nature ◽

Plant Origin

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Carnitines Increase Plasma Levels of Adenosine and ATP in Humans

Vascular Medicine ◽

10.1177/1358863x9700200201 ◽

1997 ◽

Vol 2 (2) ◽

pp. 77-81 ◽

Cited By ~ 13

Author(s):

PL Capecchi ◽

F Laghi Pasini ◽

E Quartarolo ◽

T Di Perri

Keyword(s):

Peripheral Arterial Disease ◽

Pharmacological Activity ◽

Plasma Levels ◽

Mode Of Action ◽

Peak Plasma ◽

Arterial Disease ◽

Physiological Mechanisms ◽

Tissue Protection ◽

Peripheral Arterial ◽

Carnitine Derivatives

In order to help to clarify the mode of action of carnitine derivatives, plasma levels of adenosine, ATP and inosine were evaluated following the infusion of 0.75, 0.50 and 0.25 mg/kg/min propionyl-L-carnitine (PLC) for 30 min in patients affected with peripheral arterial disease. Moreover, the effects of 0.75 mg/kg/min acetyl-L-carnitine (ALC) and L-carnitine (LC) were studied in the same conditions. Finally, the activity of 7.5 mg/kg/min PLC administered for 3 min was also evaluated. PLC and ALC produced a significant increase in plasma levels of adenosine and ATP, whereas LC induced less relevant changes. The administration of the compounds did not affect the adenosine/inosine ratio. Peak plasma levels of adenosine preceded in any case those of ATP. The possibility can be suggested that the pharmacological activity of PLC, ALC, and LC may be mediated, at least in part, by an interference with the endogenous purine system. Since these effects may be related to physiological mechanisms of tissue protection, new pharmacological perspectives for the compounds may arise.

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Molecular Targets of Naturopathy in Cancer Research: Bridge to Modern Medicine

Nutrients ◽

10.3390/nu7010321 ◽

2015 ◽

Vol 7 (1) ◽

pp. 321-334 ◽

Cited By ~ 17

Author(s):

Aamir Ahmad ◽

Kevin Ginnebaugh ◽

Yiwei Li ◽

Subhash Padhye ◽

Fazlul Sarkar

Keyword(s):

Cancer Research ◽

Molecular Targets ◽

Modern Medicine

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Phytotoxicity of Essential Oils: Opportunities and Constraints for the Development of Biopesticides. A Review

Foods ◽

10.3390/foods9091291 ◽

2020 ◽

Vol 9 (9) ◽

pp. 1291 ◽

Cited By ~ 2

Author(s):

Pierre-Yves Werrie ◽

Bastien Durenne ◽

Pierre Delaplace ◽

Marie-Laure Fauconnier

Keyword(s):

Essential Oils ◽

Pest Management ◽

Mode Of Action ◽

Molecular Targets ◽

Agricultural Practices ◽

Major Drawback ◽

Production Methods ◽

Potential Applicability ◽

Societal Expectations ◽

Chemical Pesticides

The extensive use of chemical pesticides leads to risks for both the environment and human health due to the toxicity and poor biodegradability that they may present. Farmers therefore need alternative agricultural practices including the use of natural molecules to achieve more sustainable production methods to meet consumer and societal expectations. Numerous studies have reported the potential of essential oils as biopesticides for integrated weed or pest management. However, their phytotoxic properties have long been a major drawback for their potential applicability (apart from herbicidal application). Therefore, deciphering the mode of action of essential oils exogenously applied in regards to their potential phytotoxicity will help in the development of biopesticides for sustainable agriculture. Nowadays, plant physiologists are attempting to understand the mechanisms underlying their phytotoxicity at both cellular and molecular levels using transcriptomic and metabolomic tools. This review systematically discusses the functional and cellular impacts of essential oils applied in the agronomic context. Putative molecular targets and resulting physiological disturbances are described. New opportunities regarding the development of biopesticides are discussed including biostimulation and defense elicitation or priming properties of essential oils.

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