Temporary control of ventricular arrhythmias by drug-induced sinus tachycardia

1969 ◽  
Vol 2 (3) ◽  
pp. 301
Author(s):  
L. Lemberg
Keyword(s):  
Ventricular Arrhythmias ◽  
Sinus Tachycardia ◽  
Drug Induced ◽  
Temporary Control

scholarly journals hERG K+ Channels: Structure, Function, and Clinical Significance

2012 ◽  
Vol 92 (3) ◽  
pp. 1393-1478 ◽  
Author(s):  
Jamie I. Vandenberg ◽  
Matthew D. Perry ◽  
Mark J. Perrin ◽  
Stefan A. Mann ◽  
Ying Ke ◽  
...  
Keyword(s):  
Ventricular Arrhythmias ◽  
Endocrine Cells ◽  
Sudden Cardiac Arrest ◽  
Brain Regions ◽  
Delayed Rectifier ◽  
Prescription Medications ◽  
Tumor Cell Lines ◽  
Drug Induced ◽  
Increased Risk ◽  
Wide Range

The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K+ channel, Kv11.1, which are expressed in the heart, various brain regions, smooth muscle cells, endocrine cells, and a wide range of tumor cell lines. However, it is the role that Kv11.1 channels play in the heart that has been best characterized, for two main reasons. First, it is the gene product involved in chromosome 7-associated long QT syndrome (LQTS), an inherited disorder associated with a markedly increased risk of ventricular arrhythmias and sudden cardiac death. Second, blockade of Kv11.1, by a wide range of prescription medications, causes drug-induced QT prolongation with an increase in risk of sudden cardiac arrest. In the first part of this review, the properties of Kv11.1 channels, including biogenesis, trafficking, gating, and pharmacology are discussed, while the second part focuses on the pathophysiology of Kv11.1 channels.

scholarly journals Saudi Heart Rhythm Society Task Force on Management of Potential Arrhythmogenicity Associated with Pharmacotherapy for COVID-19

2020 ◽  
Vol 40 (5) ◽  
pp. 365-372
Author(s):  
Naeem A. AlShoaibi ◽  
Khadijah Maghrabi ◽  
Haitham Alanazi ◽  
Mousa Al Harbi ◽  
Saleh Alghamdi
Keyword(s):  
Ventricular Arrhythmias ◽  
Myocardial Injury ◽  
Task Force ◽  
Heart Rhythm ◽  
Cardiovascular Complications ◽  
Qt Prolongation ◽  
Drug Induced ◽  
Global Pandemic ◽  
Risk Patients ◽  
Antiviral Medications

ABSTRACT Evidence of cardiovascular complications associated with the COVID-19 global pandemic continues to evolve. These include direct and indirect myocardial injury with subsequent acute myocardial ischemia, and cardiac arrhythmia. Some results from a limited number of trials of antiviral medications, along with chloroquine/hydroxychloroquine and azithromycin, have been beneficial. However, these pharmacotherapies may cause drug-induced QT prolongation leading to ventricular arrhythmias and sudden cardiac death. Mitigation of the potential risk in these susceptible patients may prove exceptionally challenging. The Saudi Heart Rhythm Society established a task force to perform a review of this subject based on has recently published reports, and studies and recommendations from major medical organizations. The objective of this review is to identify high-risk patients, and to set clear guidelines for management of patients receiving these pharmacotherapies.

scholarly journals Transgenic LQT2, LQT5, and LQT2‐5 rabbit models with decreased repolarisation reserve for prediction of drug‐induced ventricular arrhythmias

2020 ◽  
Vol 177 (16) ◽  
pp. 3744-3759 ◽  
Author(s):  
Tibor Hornyik ◽  
Alessandro Castiglione ◽  
Gerlind Franke ◽  
Stefanie Perez‐Feliz ◽  
Péter Major ◽  
...  
Keyword(s):  
Ventricular Arrhythmias ◽  
Drug Induced

Electrocardiographic and radiographic changes in cats with hyperthyroidism: comparison of populations evaluated during 1992-1993 vs. 1979-1982

1999 ◽  
Vol 35 (1) ◽  
pp. 27-31 ◽  
Author(s):  
PR Fox ◽  
ME Peterson ◽  
JD Broussard
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Ventricular Arrhythmias ◽  
Sinus Tachycardia ◽  
Medical Center ◽  
Low Frequency ◽  
Radiographic Evidence ◽  
Intraventricular Conduction ◽  
Two Populations ◽  
Radiographic Changes

Cardiovascular manifestations of feline hyperthyroidism were compared in two populations of cats diagnosed at The Animal Medical Center from 1992 to 1993 (n=202) and 1979 to 1982 (n = 131). The prevalence of sinus tachycardia and increased R-wave voltage in lead II were both lower in the 1993 population compared with the 1982 population (p less than 0.001). A low frequency of atrial and ventricular arrhythmias and intraventricular conduction abnormalities were recorded in both populations. No significant differences between populations were recorded in the number of cats with mild, moderate, and severe cardiomegaly seen on thoracic radiographs. The percentage of cats in which radiographs were deemed clinically necessary based upon history and clinical examination was 25% of the 1993 population, compared with 63% of the 1982 population. The number of cats with radiographic evidence of congestive heart failure was 8% in 1993 compared with 20% in 1982, although this difference was not statistically significant. In conclusion, the incidence and severity of certain thyrotoxic cardiovascular manifestations were reduced in cats diagnosed between 1992 and 1993 compared with those diagnosed between 1979 and 1982.

Abstract 16223: Cardiac Arrhythmias in Hospitalized Patients With COVID-19

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Jae Hyung Cho ◽  
Ali Namazi ◽  
Richard Shelton ◽  
Archana Ramireddy ◽  
Ashkan Ehdaie ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Ventricular Fibrillation ◽  
Interleukin 6 ◽  
Cardiac Arrhythmias ◽  
Ventricular Arrhythmias ◽  
Sinus Tachycardia ◽  
Sustained Ventricular Tachycardia ◽  
Rhythm Disorder ◽  
Baseline Characteristics

Introduction: Arrhythmias have been reported frequent in COVID-19 patients, but the incidence and nature have not been well characterized. Hypothesis: Atrial and ventricular arrhythmias are common complications of patients with COVID-19. Methods: Patients admitted with COVID-19 and monitored by telemetry were prospectively enrolled in the study. Baseline characteristics, hospital course, treatment and complications were collected from the patients’ medical records. Telemetry was monitored to detect the incidence of cardiac arrhythmias. The incidence and types of cardiac arrhythmias were analyzed and compared between survivors and non-survivors. Results: Among 143 patients admitted with telemetry monitoring, overall in-hospital mortality was 23.1% (33/143 patients) during the period of observation (mean follow up 19.9 ± 13.7 days). Survivors were younger (68.1 ± 17.2 vs. 77.6 ± 15.9 years old, p=0.006), had higher body mass index (28.1 ± 8.3 vs. 24.3 ± 6.2, p=0.019), were less tachycardic on initial presentation (heart rate 90.6 ± 19.4 vs. 99.8 ± 23.7 bpm, p=0.026) and had lower troponin (peak troponin 0.03 vs. 0.14 ng/ml. p=0.006) and interleukin-6 levels (peak interleukin-6 32 vs. 264 pg/ml, p=0.001). Sinus tachycardia, the most common arrhythmia (occurring in 39.9% [57/143] of patients), occurred more frequently in non-survivors (57.6% vs. 34.5% in survivors, p=0.018). Premature ventricular complexes occurred in 28.7% (41/143), and non-sustained ventricular tachycardia in 15.4% (22/143) of patients, with no difference between survivors and non-survivors. Sustained ventricular tachycardia and ventricular fibrillation were rare (seen only in 1.4% and 0.7% of patients, respectively). Conclusions: In this prospective observational study of hospitalized and monitored patients with COVID-19, sinus tachycardia was the most common rhythm disorder, and its presence was associated with higher mortality. Sustained ventricular tachycardia or ventricular fibrillation were infrequent, contradicting previous reports that malignant ventricular arrhythmias are commonly seen in patients hospitalized with COVID-19.

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