scholarly journals Multiple mechanisms, independent of sterol regulatory element binding proteins, regulate low density lipoprotein gene transcription

2000 ◽  
Vol 41 (5) ◽  
pp. 762-774 ◽  
Author(s):  
Robert S.J. Makar ◽  
Peter E. Lipsky ◽  
Jennifer A. Cuthbert
Keyword(s):  
Gene Transcription ◽  
Binding Proteins ◽  
Regulatory Element ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Sterol Regulatory Element

Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis

2002 ◽  
Vol 30 (6) ◽  
pp. 1091-1095 ◽  
Author(s):  
J. D. Horton
Keyword(s):  
Binding Proteins ◽  
Regulatory Element ◽  
Low Density Lipoprotein ◽  
Lipid Synthesis ◽  
Density Lipoprotein ◽  
Building Blocks ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Transcriptional Activators ◽  
Sterol Regulatory Element

Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP iso-forms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activation properties of each SREBP isoform facilitates the co-ordinate regulation of all essential lipid building blocks required for cell membranes as well as for very-low-density lipoprotein formation in hepatocytes.

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