scholarly journals Ontogeny of two vitamin A-metabolizing enzymes and two retinol-binding proteins present in the small intestine of the rat.

1991 ◽  
Vol 32 (9) ◽  
pp. 1521-1527
Author(s):  
DE Ong ◽  
PC Lucas ◽  
B Kakkad ◽  
TC Quick
Keyword(s):  
Small Intestine ◽  
Vitamin A ◽  
Binding Proteins ◽  
Metabolizing Enzymes

Effect of Vitamin A on the CD44 Expression in the Small Intestine of Rats with Obstructive Jaundice

2006 ◽  
Vol 38 (3) ◽  
pp. 347-352 ◽  
Author(s):  
Meral Sen ◽  
Aydın Inan ◽  
Sibel Yenidünya ◽  
Metin Ergin ◽  
Cenap Dener
Keyword(s):  
Small Intestine ◽  
Vitamin A ◽  
Obstructive Jaundice ◽  
Cd44 Expression

scholarly journals RNAseq Studies Reveal Distinct Transcriptional Response to Vitamin a (VA) Deficiency in Small Intestine (SI) versus Colon, Discovering Novel VA-regulated Genes (P15-002-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Zhi Chai ◽  
Yafei Lyu ◽  
Qiuyan Chen ◽  
Cheng-Hsin Wei ◽  
Lindsay Snyder ◽  
...  
Keyword(s):  
Gene Expression ◽  
Small Intestine ◽  
Vitamin A ◽  
Target Genes ◽  
Expression Profiles ◽  
Expression Patterns ◽  
Differentially Expressed Gene ◽  
Gene Expression Profiles ◽  
Illumina Hiseq ◽  
The Impact

Abstract Objectives To characterize and compare the impact of vitamin A (VA) deficiency on gene expression patterns in the small intestine (SI) and the colon, and to discover novel target genes in VA-related biological pathways. Methods vitamin A deficient (VAD) mice were generated by feeding VAD diet to pregnant C57/BL6 dams and their post-weaning offspring. Total mRNA extracted from SI and colon were sequenced using Illumina HiSeq 2500 platform. Differentially Expressed Gene (DEG), Gene Ontology (GO) enrichment, and Weighted Gene Co-expression Network Analysis (WGCNA) were performed to characterize expression patterns and co-expression patterns. Results The comparison between vitamin A sufficient (VAS) and VAD groups detected 49 and 94 DEGs in SI and colon, respectively. According to GO information, DEGs in the SI demonstrated significant enrichment in categories relevant to retinoid metabolic process, molecule binding, and immune function. Immunity related pathways, such as “humoral immune response” and “complement activation,” were positively associated with VA in SI. On the contrary, in colon, “cell division” was the only enriched category and was negatively associated with VA. WGCNA identified modules significantly correlated with VA status in SI and in colon. One of those modules contained five known retinoic acid targets. Therefore we have prioritized the other module members (e.g., Mbl2, Mmp9, Mmp13, Cxcl14 and Pkd1l2) to be investigated as candidate genes regulated by VA. Comparison of co-expression modules between SI and colon indicated distinct VA effects on these two organs. Conclusions The results show that VA deficiency alters the gene expression profiles in SI and colon quite differently. Some immune-related genes (Mbl2, Mmp9, Mmp13, Cxcl14 and Pkd1l2) may be novel targets under the control of VA in SI. Funding Sources NIH training grant and NIH research grant. Supporting Tables, Images and/or Graphs

scholarly journals Identification of 5,8-oxyretinoic acid isolated from small intestine of vitamin A-deficient rats dosed with retinoic acid.

1978 ◽  
Vol 75 (6) ◽  
pp. 2603-2605 ◽  
Author(s):  
J. L. Napoli ◽  
A. M. McCormick ◽  
H. K. Schnoes ◽  
H. F. DeLuca
Keyword(s):  
Small Intestine ◽  
Retinoic Acid ◽  
Vitamin A

scholarly journals Vitamin A, Cancer Treatment and Prevention: The New Role of Cellular Retinol Binding Proteins

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Elena Doldo ◽  
Gaetana Costanza ◽  
Sara Agostinelli ◽  
Chiara Tarquini ◽  
Amedeo Ferlosio ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Cancer Progression ◽  
Binding Proteins ◽  
Bone Growth ◽  
Animal Origin ◽  
Ovarian Cancer Cells ◽  
Tissue Remodelling ◽  
Wide Range

Retinol and vitamin A derivatives influence cell differentiation, proliferation, and apoptosis and play an important physiologic role in a wide range of biological processes. Retinol is obtained from foods of animal origin. Retinol derivatives are fundamental for vision, while retinoic acid is essential for skin and bone growth. Intracellular retinoid bioavailability is regulated by the presence of specific cytoplasmic retinol and retinoic acid binding proteins (CRBPs and CRABPs). CRBP-1, the most diffuse CRBP isoform, is a small 15 KDa cytosolic protein widely expressed and evolutionarily conserved in many tissues. CRBP-1 acts as chaperone and regulates the uptake, subsequent esterification, and bioavailability of retinol. CRBP-1 plays a major role in wound healing and arterial tissue remodelling processes. In the last years, the role of CRBP-1-related retinoid signalling during cancer progression became object of several studies. CRBP-1 downregulation associates with a more malignant phenotype in breast, ovarian, and nasopharyngeal cancers. Reexpression of CRBP-1 increased retinol sensitivity and reduced viability of ovarian cancer cellsin vitro. Further studies are needed to explore new therapeutic strategies aimed at restoring CRBP-1-mediated intracellular retinol trafficking and the meaning of CRBP-1 expression in cancer patients’ screening for a more personalized and efficacy retinoid therapy.

Sign in / Sign up

Export Citation Format

Share Document