Metal Ions in Biological Systems: Vol. 11: Metal Complexes as Anticancer Agents.

1982 ◽  
Vol 236 (2) ◽  
pp. C55-C56
Author(s):  
B. Ridge
Keyword(s):  
Metal Ions ◽  
Metal Complexes ◽  
Anticancer Agents ◽  
Biological Systems

Synthesis and Structural Systematics of First-Row Transition Metal Complexes with 2-[Bis(benzimidazol-2-ylmethyl)amino]ethanol

1987 ◽  
Vol 42 (10) ◽  
pp. 1307-1314 ◽  
Author(s):  
Kazuhiro Takahashi ◽  
Yuzo Nishida
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Structural Parameters ◽  
Biological Systems ◽  
Tridentate Ligand ◽  
Crystal Data ◽  
Space Group ◽  
Distorted Octahedral

Abstract A nickel(II) complex with (bbimae) (= 2-[bis(benzimidazol-2-ylmethyl)amino]ethanol), [Ni(bbimae)(NCS)2] · H2O (1) and an oxovanadium(IV) complex, [VO(bbimae)(NCS)2] · dma (dma = N.N-dimethylacetamide) (2) have been prepared and their crystal structures determined by X-ray diffraction. Crystal data for 1 at 293 K: a = 13.334(2). b = 17.048(2), c = 10.3829(9) Å, space group P212121, Z = 4, and dcalcd = 1.41 gcm-3. Crystal data for 2 at 293 K: a = 14.099(2). b = 14.998(4), c = 14.051(2) Å, β = 107.634(9)°, space group P21/c, Z = 4, and dcalcd = 1.36 gcm-3. In the nickel(II) complex, (bbimae) functions as a tetradentate ligand, and the geometry around Ni(II) ion is best described as distorted octahedral. The structure is very similar to those of the correspond­ing Co(II) and Mn(II) complexes. In the case of 2, which is also distorted octahedral, (bbimae) is a tridentate ligand without the coordination of the alcohol group. The M-N (benzimidazole) distances are in the range of 1.95-2.18 Å, and also observed for other first-row transition metal complexes with (bbimae). and differ in the order V(IV) < Mn(II) > Co(II) > Ni(II) > Cu(II). consistent with effective ionic radii of the metal ions. Comparison of the structural parameters of these complexes with those of the metal ions in biological systems has supported the usefulness of the tripod-like ligands to synthesis model compounds for biological systems.

scholarly journals Coordination Behavior of 3-Ethoxycarbonyltetronic Acid towards Cu(II) and Co(II) Metal Ions

2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
Giorgos Athanasellis ◽  
Georgia Zahariou ◽  
Stefanos Kikionis ◽  
Olga Igglessi-Markopoulou ◽  
John Markopoulos
Keyword(s):  
Magnetic Susceptibility ◽  
Metal Ions ◽  
Metal Complexes ◽  
Pharmacological Activity ◽  
Epr Spectroscopy ◽  
Heterocyclic Compounds ◽  
Biological Systems ◽  
Coordination Behavior ◽  
Integral Role ◽  
Complexation Reactions

Tetronic acids, 4-hydroxy-5H-furan-2-ones, constitute a class of heterocyclic compounds with potent biological and pharmacological activity. Theβ,β′-tricarbonyl moiety plays an integral role in biological systems and forms a variety of metal complexes. In this report, we present the complexation reactions of 3-ethoxycarbonyl tetronic acids with acetates and chlorides of Cu(II) and Co(II). These complexes have been studied by means of EPR spectroscopy and magnetic susceptibility measurements. From the obtained results, a preliminary complexation mode of the ligand is proposed.

Current Development of Metal Complexes with Diamine Ligands as Potential Anticancer Agents

2020 ◽  
Vol 27 (3) ◽  
pp. 380-410 ◽  
Author(s):  
Sonja Misirlic-Dencic ◽  
Jelena Poljarevic ◽  
Andjelka M. Isakovic ◽  
Tibor Sabo ◽  
Ivanka Markovic ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Complexes ◽  
Anticancer Agents ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Organic Ligand ◽  
Aromatic Diamine ◽  
Anticancer Efficacy ◽  
Anticancer Mechanism ◽  
Diamine Ligands

Background:: The discovery of cisplatin and the subsequent research revealed the importance of dinitrogen-containing moiety for the anticancer action of metal complexes. Moreover, certain diamine ligands alone display cytotoxicity that contributes to the overall activity of corresponding complexes. Objective:: To summarize the current knowledge on the anticancer efficacy, selectivity, and the mechanisms of action of metal complexes with various types of diamine ligands. Method:: The contribution of aliphatic acyclic, aliphatic cyclic, and aromatic diamine ligands to the anticancer activity and selectivity/toxicity of metal complexes with different metal ions were analyzed by comparison with organic ligand alone and/or conventional platinum-based chemotherapeutics. Results:: The aliphatic acyclic diamine ligands are present mostly in complexes with platinum. Aliphatic cyclic diamines are part of Pt(II), Ru(II) and Au(III) complexes, while aromatic diamine ligands are found in Pt(II), Ru(II), Pd(II) and Ir(III) complexes. The type and oxidation state of metal ions greatly influences the cytotoxicity of metal complexes with aliphatic acyclic diamine ligands. Lipophilicity of organic ligands, dependent on alkyl-side chain length and structure, determines their cellular uptake, with edda and eddp/eddip ligands being most useful in this regard. Aliphatic cyclic diamine ligands improved the activity/toxicity ratio of oxaliplatin-type complexes. The complexes with aromatic diamine ligands remain unexplored regarding their anticancer mechanism. The investigated complexes mainly caused apoptotic or necrotic cell death. Conclusion:: Metal complexes with diamine ligands are promising candidates for efficient and more selective alternatives to conventional platinum-based chemotherapeutics. Further research is required to reveal the chemico-physical properties and molecular mechanisms underlying their biological activity.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

Novel Chemotherapeutic Agents - The Contribution of Scorpionates

2020 ◽  
Vol 26 (41) ◽  
pp. 7452-7475 ◽  
Author(s):  
Marta A. Andrade ◽  
Luísa M.D.R.S. Martins
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Anticancer Agents ◽  
Medicinal Chemistry ◽  
Bioinorganic Chemistry ◽  
Chemotherapeutic Agents ◽  
Great Role ◽  
Anticancer Properties ◽  
Scorpionate Ligands

: The development of safe and effective chemotherapeutic agents is one of the uppermost priorities and challenges of medicinal chemistry and new transition metal complexes are being continuously designed and tested as anticancer agents. Scorpionate ligands have played a great role in coordination chemistry, since their discovery by Trofimenko in the late 1960s, with significant contributions in the fields of catalysis and bioinorganic chemistry. Scorpionate metal complexes have also shown interesting anticancer properties, and herein, the most recent (last decade) and relevant scorpionate complexes reported for application in medicinal chemistry as chemotherapeutic agents are reviewed. The current progress on the anticancer properties of transition metal complexes bearing homo- or hetero- scorpionate ligands, derived from bis- or tris-(pyrazol-1-yl)-borate or -methane moieties is highlighted.

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