Chapter 26 Studies of protective actions of nicotine on neuronal and vascular functions in the brain of rats: comparison between sympathetic noradrenergic and mesostriatal dopaminergic fiber systems, and the effect of a dopamine agonist

Stroke is a leading cause of death, but treatments are limited. This experimental study reveals that the hormone ghrelin powerfully protects the brain and its blood vessels against injury after stroke, raising the possibility that it could be exploited therapeutically.

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Protective Actions of Ghrelin Gene‐derived Peptides on the Brain after Ischemic Stroke

The FASEB Journal ◽

10.1096/fasebj.29.1_supplement.780.6 ◽

2015 ◽

Vol 29 (S1) ◽

Author(s):

Jacqueline Ku ◽

T Michael De Silva ◽

Tom Barsby ◽

Connie Wong ◽

Zane Andrews ◽

...

Keyword(s):

Ischemic Stroke ◽

Protective Actions ◽

Ghrelin Gene ◽

The Brain

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The drug treatment of parkinson’s disease

Drug and Therapeutics Bulletin ◽

10.1136/dtb.22.10.37 ◽

1984 ◽

Vol 22 (10) ◽

pp. 37-40

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Monoamine Oxidase ◽

Drug Treatment ◽

Dopamine Agonist ◽

Monoamine Oxidase B ◽

Anticholinergic Drugs ◽

Decarboxylase Inhibitor ◽

Progressive Degeneration ◽

The Brain

The symptoms of idiopathic Parkinson’s disease are due mainly to progressive degeneration of the dopaminergic nigro-striatal pathways in the brain. The drugs which can help fall into five categories: dopamine replacement, using dopa with a decarboxylase inhibitor; a dopamine agonist, bromocriptine;1 selegiline, recently introduced, which inhibits monoamine oxidase B; anticholinergic drugs; and amantadine.2 This article discusses recent ideas about the management of Parkinson’s disease, particularly about levodopa dosage, bromocriptine and selegiline.

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Bacterial meningitis as a first presentation of pituitary macroprolactinoma

Endocrinology Diabetes and Metabolism Case Reports ◽

10.1530/edm-14-0028 ◽

2014 ◽

Vol 2014 ◽

Author(s):

Niki Margari ◽

Simon Page

Keyword(s):

Bacterial Meningitis ◽

Dopamine Agonist ◽

Pneumococcal Meningitis ◽

Final Diagnosis ◽

Favourable Outcome ◽

List Type ◽

Close Monitoring ◽

Tissue Mass ◽

Csf Leakage ◽

The Brain

Summary A 56-year-old man was brought to the Emergency Department after being found collapsed at his office with a reduced level of consciousness. From clinical examination and initial investigations, he was diagnosed as having bacterial meningitis and was promptly commenced on empirical i.v. antibiotics. Computed tomography of the brain revealed a parenchymal mass at the base of the skull and subsequent magnetic resonance imaging of the head 4 days later confirmed a large soft tissue mass, which extended through to the cavernous sinus. Examination of the cerebrospinal fluid (CSF) following lumbar puncture confirmed pneumococcal meningitis and antibiotics were continued for 2 weeks in total. During the admission, hormone profiling revealed a grossly elevated prolactin. When coupled with the initial results of the brain imaging, this result helped to confirm a macroprolactinoma that was invading the postnasal space. A final diagnosis of pneumococcal meningitis secondary to invading prolactinoma was made. The patient was started on cabergoline and was followed up in the outpatient clinic upon discharge. He made a full recovery from the meningitis. Over the next few months, prolactin levels returned to be normal and the prolactinoma shrank significantly in size. The patient remains on cabergoline that will most likely be continued indefinitely. Learning points Bacterial meningitis is a rare first presentation of pituitary macroprolactinoma. Patients with invasive macroprolactinoma do not always present with CSF leakage. Prompt treatment with antibiotics and a dopamine agonist is of great importance for a favourable outcome. Close monitoring of the patient for signs of raised intracranial pressure is essential in the management of macroprolactinoma. Note the risk of CSF leakage after initiation of dopamine agonist therapy irrespective of concomitant meningitis in macroprolactinoma.

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