Reactogenicity and immunogenicity of inactivated influenza A (H1N1) virus vaccine in unprimed children. Report to the Medical Research Council Committee on influenza and other respiratory virus vaccines

1980 ◽  
Vol 8 (1) ◽  
pp. 35-48 ◽  
Author(s):  
C.W. Potter ◽  
A. Clark ◽  
R. Jennings ◽  
G.C. Schild ◽  
J.M. Wood ◽  
...  
Keyword(s):  
Medical Research ◽  
Virus Vaccine ◽  
Influenza A ◽  
Research Council ◽  
Respiratory Virus ◽  
Medical Research Council ◽  
H1n1 Virus ◽  
Influenza A H1n1

scholarly journals The efficacy of live and inactivated vaccines of Hong Kong influenza virus in an industrial community: A report to the Medical Research Council Committee on Influenza and other respiratory virus vaccines

1973 ◽  
Vol 71 (4) ◽  
pp. 641-647 ◽  
Author(s):  
D. Hobson ◽  
F. A. Baker ◽  
R. L. Curry ◽  
A. S. Beare ◽  
P. M. O. Massey
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Medical Research ◽  
Research Council ◽  
Respiratory Virus ◽  
Medical Research Council ◽  
Influenza Viruses ◽  
Protective Efficiency ◽  
Industrial Community ◽  
Inactivated Vaccines

Intranasal vaccines of inactivated or living attentuated A2/Hong Kong influenza viruses were compared for clinical acceptability, serological effects and protective efficiency against natural epidemic influenza in a large industrial and clerical population.

scholarly journals A comparison of live and inactivated influenza A (H1N1) virus vaccines

1983 ◽  
Vol 90 (3) ◽  
pp. 361-370 ◽  
Author(s):  
A. Clark ◽  
C. W. Potter ◽  
R. Jennings ◽  
J. P. Nicholl ◽  
A. F. Langrick ◽  
...  
Keyword(s):  
Virus Vaccine ◽  
Influenza A ◽  
H1n1 Virus ◽  
Serum Antibody ◽  
H1n1 Vaccine ◽  
Live Virus ◽  
Post Immunization ◽  
Influenza A H1n1 ◽  
B Virus ◽  
Antibody Titres

SUMMARYGroups of volunteers were immunized with one of three influenza virus vaccines, and the resistance to challenge infection with attenuated influenza A (H1N1) virus was measured 8 months later. The vaccines were aqueous subunit influenza A/USSR/77 (H1N1) vaccine, aqueous subunit influenza B/Hong Kong/73 vaccine, or attenuated influenza virus A (H1N1) vaccine. The B virus vaccine was included as a control to assess the incidence of natural A virus infection during the study period. A proportion of the B virus vaccinees had pre-existing A (H1N1) virus antibody and were used to study the immunity conferred by natural infection to the live virus challenge. The serum antibody responses were measured at 1 and 8 months after immunization. The results showed that all the vaccines induced serum HI antibody in a proportion of the volunteers; however, after 1 month, higher titres of serum antibody were found in volunteers given inactivated A vaccine than in those given live attenuated A virus vaccine. Eight months post-immunization the titres of serum antibody in volunteers given inactivated vaccine had declined significantly, but there were no changes in the antibody titres of those given live virus vaccine. The incidence of infection by the challenge virus at 8 months post-immunization was directly related to the serum antibody titres 1 month post-immunization; no evidence was obtained to suggest that those given live virus vaccine had a more solid immunity than those given inactivated vaccine.

scholarly journals Reactions and antibody response to live influenza vaccine prepared from the Iksha (A2) strain. (A report to the Medical Research Council by their Committee on Influenza and other Respiratory Virus Vaccines)

1967 ◽  
Vol 65 (2) ◽  
pp. 245-254 ◽  
Author(s):  
A. S. Beare ◽  
D. A. J. Tyreell ◽  
J. C. McDonald ◽  
T. M. Pollock ◽  
C. E. D. Taylor ◽  
...  
Keyword(s):  
Antibody Response ◽  
Influenza Vaccine ◽  
Medical Research ◽  
Research Council ◽  
Respiratory Virus ◽  
Medical Research Council ◽  
Field Trials

Two field trials of A 2 live influenza vaccine (Iksha) are described; the clinical reactions and antibody response in three earlier trials are compared.The antibody response in the last two trials was unsatisfactory and was inferior to that observed in the earlier investigations. This reduction in response was probably due to an alteration in the virus during further passage.

Correlação entre a frequência respiratória e escalas de avaliação de dispneia

2016 ◽  
Vol 13 (6) ◽  
Author(s):  
Ivete Alonso Bredda Saad ◽  
Mariana De Moraes ◽  
Vinicius Minatel ◽  
Bruna Alonso Saad
Keyword(s):  
Medical Research ◽  
Research Council ◽  
Medical Research Council

A avaliação da dispneia tem sido feita por meio de instrumentos como escala de Borg modificada, a escala de cores e a escala do Medical Research Council modificada (mMRC). O objetivo deste estudo foi correlacionar a frequência respiratória com a sensação de dispneia, através das escalas citadas, correlacioná-las entre si e verificar se o grau de alfabetização influenciou na resposta do paciente sobre a sensação de dispneia. Para avaliar o esforço físico utilizou-se o teste de caminhada de seis minutos. Este foi um estudo prospectivo, transversal e analítico-descritivo composto por 124 voluntários com diagnóstico de doença pulmonar. Para comparar as variáveis categóricas entre os grupos foram utilizados os testes Qui-Quadrado e exato de Fisher. Para comparar as variáveis contínuas foi utilizado o teste Kruskal-Wallis e para análise de correlação foi utilizado o coeficiente de correlação de Spearman. A idade média foi de 55,9 (± 13,08 anos), 14% eram analfabetos. Nos tempos de análise houve correlação positiva entre as escalas mMRC e Borg, r = 0,43, r = 0,61 e r = 0,55. Entre as escalas mMRC e Cores, observou-se correlação negativa. Concluiu-se que a frequência respiratória correlacionou-se com as três escalas. O grau de alfabetização não modificou a resposta do paciente em relação à sensação de dispneia.Palavras-chave: dispneia, fisioterapia, avaliação.

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