scholarly journals Effects of opiate substitution treatment on mortality for opioids users: a systematic review and meta-analysis

The Lancet ◽  
2017 ◽  
Vol 390 ◽  
pp. S56 ◽  
Author(s):  
Jun Ma ◽  
Ru-Jia Wang ◽  
Meng-Fan Su ◽  
Mo-Xuan Liu ◽  
Jie Shi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Substitution Treatment ◽  
Opiate Substitution Treatment

scholarly journals Opiate substitution treatment and HIV transmission in people who inject drugs: systematic review and meta-analysis

BMJ ◽  
2012 ◽  
Vol 345 (oct03 3) ◽  
pp. e5945-e5945 ◽  
Author(s):  
G. J. MacArthur ◽  
S. Minozzi ◽  
N. Martin ◽  
P. Vickerman ◽  
S. Deren ◽  
...  
Keyword(s):  
Systematic Review ◽  
People Who Inject Drugs ◽  
Hiv Transmission ◽  
Meta Analysis ◽  
Substitution Treatment ◽  
Opiate Substitution Treatment

scholarly journals Impact of opioid agonists on mental health in substitution treatment for opioid use disorder: A systematic review and Bayesian network meta-analysis of randomized clinical trials

2020 ◽  
Author(s):  
Ehsan Moazen-Zadeh ◽  
Kimia Ziafat ◽  
Kiana Yazdani ◽  
Mostafa Mamdouh ◽  
James Wong ◽  
...  
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Opioid Use Disorder ◽  
Substitution Treatment ◽  
Opioid Use ◽  
Psychosocial Services ◽  
Opioid Medications

AbstractObjectiveThere is a dearth of high-quality systematic evidence on the impact of opioid substitution medications on mental health. We compared mental health outcomes between opioid medications and placebo/waitlist, and between different opioids.MethodsThis systematic review and meta-analysis of randomized clinical trials (RCTs) was pre-registered at PROSPERO (CRD42018109375). Embase, MEDLINE, PsychInfo, CINAHL Complete, and Web of Science Core Collection were searched from inception to May 2020. RCTs were included if they compared opioid agonists with each other or with a placebo/waitlist in substitution treatment of patients with opioid use disorder, and reported at least one mental health outcome on a span of more than 1-month post baseline. Studies with psychiatric care, adjunct psychotropic medications, or unbalanced psychosocial services were excluded. Primary outcomes were comparison of depressive symptoms and overall mental health between opioids and placebo/waitlist. Random effects model was used for all the meta-analysis.ResultsNineteen studies were included in the narrative synthesis and 15 in the quantitative synthesis. Hydromorphone, diacetylmorphine (DAM), methadone, slow-release oral morphine, buprenorphine, and placebo/waitlist were among the included interventions. Based on network meta-analysis for primary outcomes, buprenorphine (SMD (CI95%)= −0.61 (−1.20, −0.11)), DAM (−1.40 (−2.70, −0.23)), and methadone (−1.20 (−2.30, −0.11)) were superior to waitlist/placebo on overall mental health. Further direct pairwise meta-analysis indicated that overall mental health improved more in DAM compared to methadone (−0.23 (−0.34, −0.13)).ConclusionsIt appears that opioid medications improve mental health independent of psychosocial services. Potential contribution of other factors needs to be further investigated.

scholarly journals Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies

BMJ ◽  
2017 ◽  
pp. j1550 ◽  
Author(s):  
Luis Sordo ◽  
Gregorio Barrio ◽  
Maria J Bravo ◽  
B Iciar Indave ◽  
Louisa Degenhardt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Mortality Risk ◽  
Meta Analysis ◽  
Substitution Treatment ◽  
Opioid Substitution Treatment ◽  
Opioid Substitution

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

The association between dietary inflammatory index and risk of central obesity in adults: An updated systematic review and meta-analysis

2020 ◽  
Vol 90 (5-6) ◽  
pp. 535-552 ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Mahdi Vajdi
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Central Obesity ◽  
Assessment Tool ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Dietary Factors ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Obesity Indices

Abstract. Backgrounds: Central obesity, as a pivotal component of metabolic syndrome is associated with numerous co-morbidities. Dietary factors influence central obesity by increased inflammatory status. However, recent studies didn’t evaluate the association between central obesity and dietary inflammation index (DII®) that give score to dietary factors according to their inflammatory potential. In the current systematic review and meta-analysis, we summarized the studies that investigated the association between DII® with central obesity indices in the general populations. Methods: In a systematic search from PubMed, SCOPUS, Web of Sciences and Cochrane electronic databases, we collected relevant studies written in English and published until 30 October 2019. The population of included studies were apparently healthy subjects or individuals with obesity or obesity-related diseases. Observational studies that evaluated the association between DII® and indices of central obesity including WC or WHR were included. Results: Totally thirty-two studies were included; thirty studies were cross-sectional and two were cohort studies with 103071 participants. Meta-analysis of observational studies showed that higher DII® scores were associated with 1.81 cm increase in WC (Pooled weighted mean difference (WMD) = 1.813; CI: 0.785–2.841; p = 0.001). Also, a non-significant increase in the odds of having higher WC (OR = 1.162; CI: 0.95–1.43; p = 0.154) in the highest DII category was also observed. In subgroup analysis, the continent, dietary assessment tool and gender were the heterogeneity sources. Conclusion: The findings proposed that adherence to diets with high DII® scores was associated with increased WC. Further studies with interventional designs are necessary to elucidate the causality inference between DII® and central obesity indices.

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