TISSUE-CULTURE MICROTEST FOR PREDICTING RESPONSE OF HUMAN CANCER TO CHEMOTHERAPY

The Lancet ◽  
1974 ◽  
Vol 304 (7887) ◽  
pp. 985-987 ◽  
Author(s):  
H.L. Holmes ◽  
J.M. Little
Keyword(s):  
Tissue Culture ◽  
Human Cancer

Eine Komplementbindungsreaktion zum Nachweis der bei Leukämieviren verschiedener Säuger vorkommenden gemeinsamen antigenen Komponente

1970 ◽  
Vol 25 (9) ◽  
pp. 1029-1036 ◽  
Author(s):  
Werner Schäfer ◽  
Jens Lange ◽  
Liselotte Pister ◽  
Eveline Seifert ◽  
Fernando de Noronha ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Cancer Cells ◽  
Human Cancer ◽  
Leukemia Virus ◽  
Mouse Leukemia ◽  
Human Cancer Cells ◽  
Mouse Leukemia Virus ◽  
Bovine Leukosis

By immunization of a rabbit with purified gs-antigen from mouse leukemia virus (MLV) a potent antiserum (R-gs-serum) was obtained, which reacts specifically with gs-antigen of MLV.In cat leukemia virus (KLV) two types of antigens, probably both group specific, could be demonstrated with anti-KLV-sera by Ouchterlony test. One of these was shown with MLV-sera to be identical with a MLV-gs-antigen component. This antigen occurring in both viruses is called gsinterspecies (interspec.) antigen.R-gs-serum allowed to detect gs-interspec. antigen also by the more sensitive CF-test. [Lispa (leukemia virus interspec. antigen) CF-test]. Preliminary experiments with this test indicated that bovine leukosis as well as human cancer cells can produce an agent in tissue culture which is serologically related to MLV.

scholarly journals Further investigation of the relation between the clinical and tissue culture response to chemotherapeutic agents on human cancer

Cancer ◽  
1962 ◽  
Vol 15 (2) ◽  
pp. 284-293 ◽  
Author(s):  
Jane C. Wright ◽  
Jewel P. Cobb ◽  
Stephen L. Gumport ◽  
David Safadi ◽  
Dorothy G. Walker ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Human Cancer ◽  
Chemotherapeutic Agents ◽  
Tissue Culture Response

Investigation of the Relation between Clinical and Tissue-Culture Response to Chemotherapeutic Agents on Human Cancer

1957 ◽  
Vol 257 (25) ◽  
pp. 1207-1211 ◽  
Author(s):  
Jane C. Wright ◽  
Jewel Plummer Cobb ◽  
Stephen L. Gumport ◽  
Frederick M. Golomb ◽  
David Safadi
Keyword(s):  
Tissue Culture ◽  
Human Cancer ◽  
Chemotherapeutic Agents ◽  
Tissue Culture Response

Do mycoplasmas cause human cancer?

2001 ◽  
Vol 47 (8) ◽  
pp. 691-697 ◽  
Author(s):  
Nevio Cimolai
Keyword(s):  
Tissue Culture ◽  
Molecular Mechanisms ◽  
Human Cancer ◽  
Epidemiological Studies ◽  
Respiratory Pathogen ◽  
The Novel ◽  
The 1960S ◽  
In Vitro Data

A linkage between mycoplasmas and malignancy was mainly proposed in the 1960s when human-associated mycoplasmas were becoming of interest given the novel characterization of the human respiratory pathogen Mycoplasma pneumoniae. Associations with leukemia and other malignancies, however, were largely ascribed to tissue-culture contamination, which is now recognized as a significant potential problem in molecular biology circles. A few epidemiological studies, however, continue to raise concern over such a linkage. As well, in vitro data have demonstrated the potential for some mycoplasmas to induce karyotypic changes and malignant transformation during chronic tissue-culture infestation. As cellular and molecular mechanisms for such transformation become studied, a resurgence of interest in this area is inevitable. A role for mycoplasmas in malignancy of any sort is conjectural, but there remains a need to continue with focussed epidemiological and laboratory investigations.Key words: mycoplasma, cancer, oncogenesis, leukemia.

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