Spatial learning in male mice with different levels of aggressiveness: effects of housing conditions and nicotine administration

2003 ◽  
Vol 147 (1-2) ◽  
pp. 1-8 ◽  
Author(s):  
I. Moragrega ◽  
M.C. Carrasco ◽  
P. Vicens ◽  
R. Redolat
Keyword(s):  
Spatial Learning ◽  
Housing Conditions ◽  
Male Mice ◽  
Nicotine Administration ◽  
Different Levels

scholarly journals Influence of gonadal hormones on the behavioral effects of intermittent hypoxia in mice

2015 ◽  
Vol 308 (6) ◽  
pp. R489-R499 ◽  
Author(s):  
Taryn G. Aubrecht ◽  
Richelle Jenkins ◽  
Ulysses J. Magalang ◽  
Randy J. Nelson
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Intermittent Hypoxia ◽  
Upper Airway ◽  
Premenopausal Women ◽  
Gonadal Hormones ◽  
Spatial Learning And Memory ◽  
Male Mice ◽  
Intact Male ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) is characterized by repetitive upper airway obstruction resulting in cyclic intermittent hypoxia (IH) during sleep in affected individuals. OSA occurs more frequently in postmenopausal than premenopausal women and the severity of OSA increases after menopause. Gonadal hormones can influence brain and behavior; testosterone and estrogens in particular can enhance spatial learning and memory. We hypothesized that estrogens may protect mice from IH-induced hippocampal morphological and behavioral changes. To test this hypothesis we exposed intact or gonadectomized male and female mice to room air or IH [15 cycles/h, 8 h/day, fraction of inspired oxygen (FiO2) nadir of 5%] for a total of 30 days. During the final 4 days of IH, mice were tested for anxiety- and depressive-like behaviors. After cessation of IH exposure mice were tested on the Barnes maze and passive avoidance tests to assess learning and memory. Ovariectomy paired with IH treatment, impaired spatial learning and memory compared to all other female groups. Intact male mice receiving IH treatment also had impaired learning and memory compared with intact or castrated male mice exposed to room air. Learning and memory changes were mirrored by changes in basilar dendritic length of the CA1 region of the hippocampus. These data suggest that estrogens provide protection against IH-induced deficits, whereas androgens partially exacerbate IH-induced deficits on learning and memory.

scholarly journals Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis

2002 ◽  
Vol 364 (1) ◽  
pp. 115-120 ◽  
Author(s):  
Josie L. FALANY ◽  
Heather GREER ◽  
Timea KOVACS ◽  
Eric J. SORSCHER ◽  
Charles N. FALANY
Keyword(s):  
Cystic Fibrosis ◽  
Mouse Liver ◽  
Northern Blot Analysis ◽  
Transmembrane Conductance Regulator ◽  
Male Mice ◽  
Transmembrane Conductance ◽  
Female Adult ◽  
Cf Transmembrane Conductance Regulator ◽  
Different Levels

The severity of intestinal disease in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) (-/−) mice has been reported to co-segregate with gene loci which contain the genes for hydroxysteroid sulphotransferase (SULT). Because of the potential involvement of steroid hormones in CF, we investigated levels of steroid SULT activity in the livers of CFTR mice to determine whether the levels of SULT activity correlate with the occurrence or severity of CF. To elucidate the possible role of SULT activity in ameliorating the deleterious effects of CF in CFTR (-/−) mice, we determined the levels of phenol SULT (PST), hydroxysteroid SULT [dehydroepiandrosterone (DHEA)-ST] and oestrogen SULT (EST) activity in control CFTR (+/+), heterozygous CFTR (+/−) and homozygous CFTR (-/−) mice, which survive to adulthood. The level of PST activity was not significantly different between any of the groups of mice, regardless of sex or genotype. Although DHEA-ST activity was significantly higher in female mice than in male mice, there was no difference in DHEA-ST activity that could be correlated with genotype. In contrast with PST and DHEA-ST activities, we found that some male and all female adult CFTR (-/−) mice had elevated, dramatically different levels of EST from both CFTR (+/+) and CFTR (+/−) mice. Results from these SULT activity experiments were confirmed by Northern-blot analysis of mouse-liver RNA. Subsequent studies with preweanling mice revealed no differences in the levels of EST that could be correlated with genotype. Thus this study indicates that EST is elevated significantly in CFTR (-/−) mice which survive to adulthood and provides important biochemical information that EST levels may be protective in CF.

Subordinate male mice show long-lasting differences in spatial learning that persist when housed alone

2005 ◽  
Vol 84 (3) ◽  
pp. 247-251 ◽  
Author(s):  
Ann E. Fitchett ◽  
Sarah A. Collins ◽  
Christopher J Barnard ◽  
Helen J. Cassaday
Keyword(s):  
Spatial Learning ◽  
Male Mice ◽  
Subordinate Male

Parallel Recovery of MK-801–Induced Spatial Learning Impairment and Neuronal Injury in Male Mice

1999 ◽  
Vol 62 (1) ◽  
pp. 111-122 ◽  
Author(s):  
G. Brosnan-Watters ◽  
D.F. Wozniak ◽  
A. Nardi ◽  
J.W. Olney
Keyword(s):  
Spatial Learning ◽  
Neuronal Injury ◽  
Male Mice ◽  
Mk 801 ◽  
Learning Impairment

MK-801 neurotoxicity in male mice: histologic effects and chronic impairment in spatial learning

1996 ◽  
Vol 707 (2) ◽  
pp. 165-179 ◽  
Author(s):  
D.F. Wozniak ◽  
G. Brosnan-Watters ◽  
A. Nardi ◽  
M. McEwen ◽  
T.D. Corso ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Male Mice ◽  
Mk 801

ADRENOCORTICAL RESPONSES AND CHANGES DURING THE OESTROUS CYCLE IN MICE: EFFECTS OF MALE PRESENCE, MALE URINE AND HOUSING CONDITIONS

1981 ◽  
Vol 91 (2) ◽  
pp. 263-269 ◽  
Author(s):  
D. J. NICHOLS ◽  
P. F. D. CHEVINS
Keyword(s):  
Virgin Female ◽  
Plasma Corticosterone ◽  
Housing Conditions ◽  
Male Mice ◽  
Single Application ◽  
Environmental Signals ◽  
Male Urine ◽  
Induced Stress ◽  
Adrenal System ◽  
Adrenocortical Responses

Male urine applied daily to their bedding raised the basal levels of plasma corticosterone in individually housed, virgin female mice, when compared with females (grouped or individually housed) living with male mice or with group-housed females exposed daily to male urine. Values were not affected during ether-induced stress. A single application of male urine raised plasma levels 30 min later regardless of housing conditions; but after 4 and 24 h levels had fallen to normal. The results are discussed in terms of sensitization of the pituitary-adrenal system and of stress and reproductive pheromones. Male urine was less effective than male presence at inducing 4-day oestrous cycles. Length and type of cycle varied continuously under the influence of a spectrum of environmental signals.

scholarly journals Nicotine Oral Administration Attenuates DSS-Induced Colitis Through Upregulation of Indole in the Distal Colon and Rectum in Mice

2021 ◽  
Vol 8 ◽  
Author(s):  
Akihito Nakajima ◽  
Tomoyoshi Shibuya ◽  
Takashi Sasaki ◽  
Yu Jie Lu ◽  
Dai Ishikawa ◽  
...  
Keyword(s):  
Oral Administration ◽  
Potential Role ◽  
Distal Colon ◽  
Short Chain Fatty Acids ◽  
Proximal Colon ◽  
Gut Contents ◽  
Male Mice ◽  
Histological Changes ◽  
Nicotine Administration ◽  
Colon And Rectum

Nicotine affects the gastrointestinal environment and modulates ulcerative colitis (UC). However, the associations among nicotine, gut metabolites, and UC are still largely unknown. We investigated whether orally administered nicotine affected gut metabolites and dextran sodium sulfate (DSS)-induced colitis. C57BL/6 male mice were orally administered nicotine solution in drinking water prior to inducing DSS-induced colitis. Short-chain fatty acids (SCFAs) and indole in gut contents and fecal samples were measured by GC-MS and hydroxylamine-based indole assays, respectively. Oral administration of nicotine increased indole concentration in feces, but, in contrast, SCFA values did not differ with nicotine administration. Indole levels were increased in the distal colon and rectum but not in the cecum and proximal colon. DSS-induced colitis was less severe clinically and histological changes were minimal in the rectum of orally nicotine-administered mice compared to mice drinking only water. 16S rRNA microbiome on the feces revealed an increasing in Clostridium and Porphyromonas in nicotine-administered mice. In conclusion, nicotine administration was associated with increased indole levels in the distal colon and rectum and attenuated DSS-induced colitis. Oral administration of nicotine may play a potential role in indole upregulation and prevention of UC.

scholarly journals Egg Albumin Supplementation Decreases Isolation-Induced Aggression in Male White

2015 ◽  
pp. 70-80
Author(s):  
Francis Legario ◽  
Maureen Antonette Bereber
Keyword(s):  
Aggressive Behavior ◽  
Mus Musculus ◽  
Negative Control ◽  
Test Results ◽  
Male Mice ◽  
Egg Albumin ◽  
Homologous Genes ◽  
Significant Difference ◽  
Status Analysis ◽  
Different Levels

There is a need to search for solutions of minimizing aggression so as to minimize violence. The purpose of the study is to determine the effects of different levels of egg albumin supplementation to the aggressive behavior of male white mice (Mus musculus). Specifically, this study aimed to describe aggressive tendencies by isolation-induced fighting of male white mice when fed different levels of egg albumin; determine aggressive behavior in terms of the number of attacks and body scars when fed different levels of egg albumin; and measure dominant-subordinate status when fed different levels of egg albumin. White mice were chosen as test animals since they have homologous genes coding with humans. Furthermore, aggression tends to be more common among male mice than female mice. T-test results showed that there is a significant difference in the aggressive behavior between the treated and untreated mice in all treatments except for Treatment D (negative control) in terms of number of attacks and body scars and a significant difference in all treatments in terms of the dominant-subordinate status. Analysis of Variance (ANOVA) showed a significant difference in the number of attacks and the dominant subordinate status. Overall, results showed that egg albumin supplementation reduced aggression in male white mice regardless of the level of egg albumin. It was concretely shown that treatments fed with varied levels of egg albumin significantly alleviated aggressive behavior compared with treatments without egg albumin supplementation.

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