Frank, Andreas O., C. J. Charles Chuong, and Robert L. Johnson. A finite-element model of oxygen diffusion in the pulmonary capillaries. J. Appl. Physiol. 82(6): 2036–2044, 1997.—We determined the overall pulmonary diffusing capacity (Dl) and the diffusing capacities of the alveolar membrane (Dm) and the red blood cell (RBC) segments (De) of the diffusional pathway for O2 by using a two-dimensional finite-element model developed to represent the sheet-flow characteristics of pulmonary capillaries. An axisymmetric model was also considered to assess the effect of geometric configuration. Results showed the membrane segment contributing the major resistance, with the RBC segment resistance increasing as O2 saturation ([Formula: see text]) rises during the RBC transit: RBC contributed 7% of the total resistance at the capillary inlet ([Formula: see text] = 75%) and 30% toward the capillary end ([Formula: see text] = 95%) for a 45% hematocrit (Hct). Both Dm and Dlincreased as the Hct increased but began approaching a plateau near an Hct of 35%, due to competition between RBCs for O2 influx. Both Dm and Dl were found to be relatively insensitive (2∼4%) to changes in plasma protein concentration (28∼45%). Axisymmetric results showed similar trends for all Hct and protein concentrations but consistently overestimated the diffusing capacities (∼2.2 times), primarily because of an exaggerated air-tissue barrier surface area. The two-dimensional model correlated reasonably well with experimental data and can better represent the O2 uptake of the pulmonary capillary bed.