PO-068 Locoregional Relapse Impact on Survival for Resected Early Stage Oral Tongue Carcinoma

Background: Carcinoma of oral tongue has a great potential for metastatic spread to neck nodes, which may not be clinically detected in early stage. To detect frequency of occult neck metastasis in clinically No patients with early oral tongue carcinoma (stage I & II) the study has done. Methods: It was a 2 years cross sectional study among fifty patients in three tertiary care hospitals of Dhaka from 2016 to 2018. Results: Majority of the patients were male (M:F=3:2) with age ranged 25 to 80 years. Among these patients 38(76%) were in T1 and remaining 12(24%) in T2 stage. Tongue ulceration was most common(84%) presenting feature followed by dysphagia(64%) and pain(52%).Only 32(64%) patients revealed no histopathological proved metastasis(true N0). Occult nodal metastasis was significantly common(83.33%) among male patients than females(p<0.01) and also common(72.22%) among < 50 years age group(p<0.01).Sampling node positive was significantly more(66.67%) in T2 stage(p<0.01). Conclusion: Regarding clinical, radiological and histopathological stages and stage migration of early carcinoma in oral tongue this study revealed significant differentiation among these methods. This study implies sampling neck dissection of sentinel neck nodes in early oral tongue carcinoma for management. Bangladesh J Otorhinolaryngol; October 2020; 26(2): 147-152

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Recurrence Pattern of Early Stage- Node Negative Oral Tongue Carcinoma Post Operative - A Retrospective Study

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v7i3.20 ◽

2019 ◽

Vol 7 (3) ◽

Author(s):

Dr R. Giridharan ◽

Keyword(s):

Retrospective Study ◽

Early Stage ◽

Tongue Carcinoma ◽

Recurrence Pattern ◽

Oral Tongue ◽

Node Negative

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Locoregional Relapse and Distant Metastasis in Conservatively Managed Triple Negative Early-Stage Breast Cancer

Breast Diseases A Year Book Quarterly ◽

10.1016/s1043-321x(07)80435-8 ◽

2008 ◽

Vol 18 (4) ◽

pp. 401-402

Author(s):

C.R. Osborne

Keyword(s):

Breast Cancer ◽

Distant Metastasis ◽

Triple Negative ◽

Early Stage ◽

Early Stage Breast Cancer ◽

Locoregional Relapse

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Improving Risk Stratification of Early Oral Tongue Cancer with TNM-Immune (TNM-I) Staging System

Cancers ◽

10.3390/cancers13133235 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3235

Author(s):

Alhadi Almangush ◽

Ibrahim O. Bello ◽

Ilkka Heikkinen ◽

Jaana Hagström ◽

Caj Haglund ◽

...

Keyword(s):

Overall Survival ◽

Tongue Cancer ◽

Early Stage ◽

Disease Free Survival ◽

Tumor Infiltrating Lymphocytes ◽

Staging System ◽

Oral Tongue ◽

Oral Tongue Cancer ◽

Important Player ◽

Infiltrating Lymphocytes

Although patients with early-stage oral tongue squamous cell carcinoma (OTSCC) show better survival than those with advanced disease, there is still a number of early-stage cases who will suffer from recurrence, cancer-related mortality and worse overall survival. Incorporation of an immune descriptive factor in the staging system can aid in improving risk assessment of early OTSCC. A total of 290 cases of early-stage OTSCC re-classified according to the American Joint Committee on Cancer (AJCC 8) staging were included in this study. Scores of tumor-infiltrating lymphocytes (TILs) were divided as low or high and incorporated in TNM AJCC 8 to form our proposed TNM-Immune system. Using AJCC 8, there were no significant differences in survival between T1 and T2 tumors (p > 0.05). Our proposed TNM-Immune staging system allowed for significant discrimination in risk between tumors of T1N0M0-Immune vs. T2N0M0-Immune. The latter associated with a worse overall survival with hazard ratio (HR) of 2.87 (95% CI 1.92–4.28; p < 0.001); HR of 2.41 (95% CI 1.26–4.60; p = 0.008) for disease-specific survival; and HR of 1.97 (95% CI 1.13–3.43; p = 0.017) for disease-free survival. The TNM-Immune staging system showed a powerful ability to identify cases with worse survival. The immune response is an important player which can be assessed by evaluating TILs, and it can be implemented in the staging criteria of early OTSCC. TNM-Immune staging forms a step towards a more personalized classification of early OTSCC.

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