The effect of Pluronic on the protein release kinetics of an injectable drug delivery system

2003 ◽  
Vol 86 (1) ◽  
pp. 15-24 ◽  
Author(s):  
J.R DesNoyer ◽  
A.J McHugh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Kinetics ◽  
Protein Release ◽  
Injectable Drug ◽  
Kinetics Of

Preparation and release kinetics of carboxymethyl chitosan/cellulose acetate microspheres as drug delivery system

2015 ◽  
Vol 132 (26) ◽  
pp. n/a-n/a ◽  
Author(s):  
Hui Yun Zhou ◽  
Pei Pei Cao ◽  
Jun Bo Li ◽  
Fa Liang Zhang ◽  
Pei Pei Ding
Keyword(s):  
Drug Delivery ◽  
Cellulose Acetate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Kinetics ◽  
Carboxymethyl Chitosan ◽  
Kinetics Of

scholarly journals Injectable Drug Delivery System Based on in Situ Self‐Assembly of Liquid Star PEG‐PLGA

2020 ◽  
pp. 2000069
Author(s):  
Bat-Hen Eylon ◽  
Alona Shagan ◽  
Ayelet Shabtay-Orbach ◽  
Adi Gross ◽  
Boaz Mizrahi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
Injectable Drug

Development of a novel injectable drug delivery system for subconjunctival glaucoma treatment

2015 ◽  
Vol 214 ◽  
pp. 1-11 ◽  
Author(s):  
Karsten Voss ◽  
Karen Falke ◽  
Arne Bernsdorf ◽  
Niels Grabow ◽  
Christian Kastner ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Injectable Drug ◽  
Glaucoma Treatment

scholarly journals QbD-Based Development and Evaluation of Time-dependent Chronopharmaceutical Drug Delivery System of Amoxicillin Trihydrate for Management of Bacterial Infection

2018 ◽  
Vol 10 (03) ◽  
Author(s):  
Shyam Narayan Prasad ◽  
Ashok Kumar Sahoo ◽  
Abhijit V. Gothoskar
Keyword(s):  
Drug Delivery ◽  
Bacterial Infection ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bacterial Infections ◽  
Release Kinetics ◽  
Matrix Tablets ◽  
Critical Material ◽  
Amoxicillin Trihydrate

The present studies discuss about the quality by design (QbD)-based development and evaluation of chronomodulated release drug delivery system of amoxicillin trihydrate for management of bacterial infection. Initially, target product profile was defined and critical quality attributes were earmarked. Risk assessment study was performed for identifying the critical material attributes. Preformulation studies were carried out, and direct compression method was employed for the preparation of bilayer matrix tablets containing a delayed and a sustained release layer for preliminary optimization. Systematic formulation optimization was carried out using central composite design by selecting the concentration of Eudragit-L100 D55 and HPMCK4M. Mathematical modeling was performed and optimized compositions of the polymers were identified from the design space. Moreover, the prepared bilayer tablets were evaluated for various tablet properties including in vitro drug release study, release kinetics evaluation and characterized for FTIR, DSC, XRD, SEM studies, in vitro was-off test, antimicrobial assay and accelerated stability studies. In a nutshell, the present studies indicated the supremacy of designing a chronomodulated release bilayer tablet formulations of amoxicillin trihydrate for effective management of bacterial infections.

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