Preparation and release kinetics of carboxymethyl chitosan/cellulose acetate microspheres as drug delivery system

The present studies discuss about the quality by design (QbD)-based development and evaluation of chronomodulated release drug delivery system of amoxicillin trihydrate for management of bacterial infection. Initially, target product profile was defined and critical quality attributes were earmarked. Risk assessment study was performed for identifying the critical material attributes. Preformulation studies were carried out, and direct compression method was employed for the preparation of bilayer matrix tablets containing a delayed and a sustained release layer for preliminary optimization. Systematic formulation optimization was carried out using central composite design by selecting the concentration of Eudragit-L100 D55 and HPMCK4M. Mathematical modeling was performed and optimized compositions of the polymers were identified from the design space. Moreover, the prepared bilayer tablets were evaluated for various tablet properties including in vitro drug release study, release kinetics evaluation and characterized for FTIR, DSC, XRD, SEM studies, in vitro was-off test, antimicrobial assay and accelerated stability studies. In a nutshell, the present studies indicated the supremacy of designing a chronomodulated release bilayer tablet formulations of amoxicillin trihydrate for effective management of bacterial infections.

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NOVEL SYNTHESIS OF PEG COATED IRON NANOPARTICLES (Fe3O4) AND IT’S EVALUATION OF CONTROLLED RELEASE KINETICS IN DRUG DELIVERY SYSTEM

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v0i0.890 ◽

2014 ◽

Vol 0 (0) ◽

Author(s):

Doppalapudi Swathi ◽

Sarala Devi

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Drug Delivery System ◽

Delivery System ◽

Iron Nanoparticles ◽

Release Kinetics ◽

Novel Synthesis

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Blend Electrospinning of Poly(Ɛ-Caprolactone) and Poly(Ethylene Glycol-400) Nanofibers Loaded with Ibuprofen as a Potential Drug Delivery System for Wound Dressings

Autex Research Journal ◽

10.2478/aut-2021-0017 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Tabinda Riaz ◽

Nabyl Khenoussi ◽

Delia Mihaela Rata ◽

Leonard Ionut Atanase ◽

Dominique C. Adolphe ◽

...

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Drug Delivery System ◽

Delivery System ◽

Release Kinetics ◽

Poly Ethylene Glycol ◽

Vis Spectroscopy ◽

Poly Ethylene ◽

The Impact

Abstract Electrospinning (ES) is a versatile and diverse technique to fabricate nano and micro fibers that could be utilized as drug delivery systems. The aim of this research was the fabrication and characterization of drug loaded nanofibrous scaffold produced by single-needle ES using poly(Ɛ-caprolactone) (PCL) and poly(ethylene glycol-400) (PEG) and to investigate the potential of this material as a drug delivery system. A model drug, Ibuprofen (IBU), was used. Ibuprofen is a medicine that is a non-steroidal, anti-inflammatory drug (NSAID). Two concentrations of IBU, 5 wt% and 7 wt%, were incorporated for the ES of PCL and PCL/PEG nanofibers. Characterization of nanofibers was done by using Scanning Electron Microscopy (SEM), Differential Scanning Calorimeter (DSC), Thermogravimetric Analysis (TGA), and Water Contact Angle Measurements. The impact of IBU on nanofibers’ properties such as morphology, diameters, hydrophilicity, and tensile strength was investigated. Finally, the drug release kinetics of IBU from nanofibers was analyzed and their percentage release efficiency of IBU (RE%) was determined by UV-vis spectroscopy during 24 h.

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pH-responsive surface charge reversal carboxymethyl chitosan-based drug delivery system for pH and reduction dual-responsive triggered DOX release

Carbohydrate Polymers ◽

10.1016/j.carbpol.2020.116093 ◽

2020 ◽

Vol 236 ◽

pp. 116093 ◽

Cited By ~ 4

Author(s):

Pengwei Xie ◽

Peng Liu

Keyword(s):

Drug Delivery ◽

Surface Charge ◽

Drug Delivery System ◽

Delivery System ◽

Carboxymethyl Chitosan ◽

Ph Responsive ◽

Charge Reversal ◽

Dual Responsive

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Charge-conversion and ultrasound-responsive O-carboxymethyl chitosan nanodroplets for controlled drug delivery

Nanomedicine ◽

10.2217/nnm-2019-0217 ◽

2019 ◽

Vol 14 (19) ◽

pp. 2549-2565 ◽

Cited By ~ 5

Author(s):

Dong Meng ◽

Lu Guo ◽

Dandan Shi ◽

Xiao Sun ◽

Mengmeng Shang ◽

...

Keyword(s):

Drug Delivery ◽

Tumor Cells ◽

Drug Delivery System ◽

Ultrasound Imaging ◽

Delivery System ◽

Cell Interaction ◽

Carboxymethyl Chitosan ◽

Ultrasound Exposure ◽

Interaction Efficiency

Aim: O-carboxymethyl chitosan/perfluorohexane nanodroplets (O-CS NDs) and doxorubicin-loading O-carboxymethyl chitosan nanodroplets were synthesized and functionally tested as drug delivery system in vitro. Materials & methods: The characteristics, charge conversion, stability, cytotoxicity, ultrasound imaging ability, interaction with tumor cells of the nanodroplets and eradication on tumor cells of the doxorubicin-loaded nanodroplets were investigated. Results: O-CS NDs (below 200 nm) achieved higher tumor cellular associations at acidic pH, with great serum stability, pH-dependent charge conversion and good ultrasound imaging ability. Doxorubicin-loading O-carboxymethyl chitosan nanodroplets exhibited strong cytotoxicity on PC-3 cells with ultrasound exposure. Conclusion: These stable, safe and smart O-CS NDs may be a promising approach to improve cell interaction efficiency as an ultrasound imaging and cancer-targeting drug delivery system.

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