585 ALLOPURINOL PROTECTS AGAINST ACUTE LIVER DAMAGE AND PREVENTS AND REVERSES CIRRHOSIS INDUCED BY CARBON TETRACHLORIDE: ROLE OF CYTOKINES MODULATION AND OXIDATIVE STRESS

2011 ◽  
Vol 54 ◽  
pp. S238
Author(s):  
L.R. Aldaba-Muruato ◽  
M. Galicia-Moreno ◽  
M. Shibayama ◽  
M.G. Moreno ◽  
P. Muriel
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Acute Liver Damage ◽  
And Oxidative Stress

scholarly journals Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats

2019 ◽  
Vol 43 (1) ◽  
Author(s):  
Mir Ajaz Akram ◽  
Manju Tembhre ◽  
Ruqaya Jabeen ◽  
Shah Khalid ◽  
Muzafar Ahmad Sheikh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Rosmarinus Officinalis ◽  
Defensive Role ◽  
And Oxidative Stress

scholarly journals Protective Role of Genistein in Acute Liver Damage Induced by Carbon Tetrachloride

2007 ◽  
Vol 2007 ◽  
pp. 1-6 ◽  
Author(s):  
Nalan Kuzu ◽  
Kerem Metin ◽  
Adile Ferda Dagli ◽  
Fatih Akdemir ◽  
Cemal Orhan ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Protective Role ◽  
Acute Liver Damage

Role of L-carnitine in the prevention of acute liver damage induced by carbon tetrachloride in rats

2004 ◽  
Vol 19 (3) ◽  
pp. 333-338 ◽  
Author(s):  
KUTBEDDIN DEMIRDAG ◽  
IBRAHIM HALIL BAHCECIOGLU ◽  
IBRAHIM HANIFI OZERCAN ◽  
MEHMET OZDEN ◽  
SEVAL YILMAZ ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Acute Liver Damage

scholarly journals Acute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
C. S. Bruells ◽  
P. Duschner ◽  
G. Marx ◽  
G. Gayan-Ramirez ◽  
N. Frank ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Liver Injury ◽  
Liver Damage ◽  
Acute Liver Injury ◽  
Serum Levels ◽  
Acute Liver Damage ◽  
Markers Of Inflammation ◽  
Amino Phenol ◽  
And Oxidative Stress

AbstractN-acetyl-para-amino phenol (APAP, usually named paracetamol), which is commonly used for its analgesic and antipyretic properties may lead to hepatotoxicity and acute liver damage in case of overdoses. Released cytokines and oxidative stress following acute liver damage may affect other organs’ function notably the diaphragm, which is particularly sensitive to oxidative stress and circulating cytokines. We addressed this issue in a mouse model of acute liver injury induced by administration of APAP. C57BL/6J mice (each n = 8) were treated with N-acetyl-para-amino phenol (APAP) to induce acute drug caused liver injury and sacrificed 12 or 24 h afterwards. An untreated group served as controls. Key markers of inflammation, proteolysis, autophagy and oxidative stress were measured in diaphragm samples. In APAP treated animals, liver damage was proven by the enhanced serum levels of alanine aminotransferase and aspartate aminotransferase. In the diaphragm, besides a significant increase in IL 6 and lipid peroxidation, no changes were observed in key markers of the proteolytic, and autophagy signaling pathways, other inflammatory markers and fiber dimensions. The first 24 h of acute liver damage did not impair diaphragm atrophic pathways although it slightly enhanced IL-6 and lipid peroxidation. Whether longer exposure might affect the diaphragm needs to be addressed in future experiments.

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