TFF peptides in the human false vocal folds of the larynx

AbstractBackground:A 29-year-old man presented with sudden onset of severe pain in his throat, difficulty breathing and a hoarse voice, following an episode of vomiting.Investigations:Initial laboratory tests were normal. The patient underwent fibre-optic nasendoscopy, which demonstrated a haematoma in the piriform fossa. Lateral neck radiography and subsequent computed tomography scanning confirmed a 2 cm, loculated, gas-containing collection at the level of the vallecula in the right posterolateral wall, extending to the false vocal folds and communicating between the right parapharyngeal space and the right carotid sheath. Water-soluble contrast swallow confirmed the diagnosis.Diagnosis:Contained oesophageal perforation.Management:Conservative treatment was adopted involving nil orally, intravenous antibiotics and nasogastric feeding. The patient made an uneventful recovery.

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The effects of the false vocal folds on laryngeal pressures and flows

The Journal of the Acoustical Society of America ◽

10.1121/1.4781441 ◽

2006 ◽

Vol 120 (5) ◽

pp. 3354-3354

Author(s):

Li Sheng ◽

Ronald C. Scherer ◽

Wan MingXi ◽

Wang SuPin ◽

Qi LiYun

Keyword(s):

Vocal Folds ◽

False Vocal

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Effects of False Vocal Folds on Intraglottal Velocity Fields

Journal of Voice ◽

10.1016/j.jvoice.2020.02.001 ◽

2020 ◽

Author(s):

Liran Oren ◽

Sid Khosla ◽

Charles Farbos de Luzan ◽

Ephraim Gutmark

Keyword(s):

Vocal Folds ◽

Velocity Fields ◽

False Vocal

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Flow Visualization and Acoustic Consequences of the Air Moving Through a Static Model of the Human Larynx

Journal of Biomechanical Engineering ◽

10.1115/1.2187042 ◽

2005 ◽

Vol 128 (3) ◽

pp. 380-390 ◽

Cited By ~ 37

Author(s):

Bogdan R. Kucinschi ◽

Ronald C. Scherer ◽

Kenneth J. DeWitt ◽

Terry T. M. Ng

Keyword(s):

Flow Visualization ◽

Flow Structure ◽

Flow Rate ◽

Real Life ◽

Vocal Folds ◽

Jet Flow ◽

Scale Model ◽

Flow Structures ◽

Human Larynx ◽

False Vocal

Flow visualization with smoke particles illuminated by a laser sheet was used to obtain a qualitative description of the air flow structures through a dynamically similar 7.5× symmetric static scale model of the human larynx (divergence angle of 10deg, minimal diameter of 0.04cm real life). The acoustic level downstream of the vocal folds was measured by using a condenser microphone. False vocal folds (FVFs) were included. In general, the glottal flow was laminar and bistable. The glottal jet curvature increased with flow rate and decreased with the presence of the FVFs. The glottal exit flow for the lowest flow rate showed a curved jet which remained laminar for all geometries. For the higher flow rates, the jet flow patterns exiting the glottis showed a laminar jet core, transitioning to vortical structures, and leading spatially to turbulent dissipation. This structure was shortened and tightened with an increase in flow rate. The narrow FVF gap lengthened the flow structure and reduced jet curvature via acceleration of the flow. These results suggest that laryngeal flow resistance and the complex jet flow structure exiting the glottis are highly affected by flow rate and the presence of the false vocal folds. Acoustic consequences are discussed in terms of the quadrupole- and dipole-type sound sources due to ordered flow structures.

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Botulinum toxin treatment of false vocal folds in adductor spasmodic dysphonia: Functional outcomes

The Laryngoscope ◽

10.1002/lary.25515 ◽

2015 ◽

Vol 126 (1) ◽

pp. 118-121 ◽

Cited By ~ 11

Author(s):

C. Blake Simpson ◽

Christopher T. Lee ◽

Jeanne L. Hatcher ◽

Joel Michalek

Keyword(s):

Botulinum Toxin ◽

Functional Outcomes ◽

Vocal Folds ◽

Spasmodic Dysphonia ◽

Adductor Spasmodic Dysphonia ◽

Botulinum Toxin Treatment ◽

False Vocal

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Influence of False Vocal Folds Gap on the Glottal Jet Flow

ASME 2012 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2012-80313 ◽

2012 ◽

Author(s):

Mehrdad H. Farahani ◽

John Mousel ◽

Fariborz Alipour ◽

Sarah Vigmostad

Keyword(s):

Vocal Folds ◽

Jet Flow ◽

Modern Life ◽

False Vocal ◽

Ventricular Folds ◽

Shape And Size

Despite the large incidence of speech problems in the modern life, our knowledge about the effect of supraglottic laryngeal structures on human phonation is lacking. These structures are mainly consisting of aryepiglottic folds, epiglottis, arytenoids, and false folds (ventricular folds). Shape and size of these structures depends on several factors including race, gender, age, and laryngeal abnormalities.

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Dynamical behavior in hemilarynx experiments with the false vocal folds attached

The Journal of the Acoustical Society of America ◽

10.1121/1.4708547 ◽

2012 ◽

Vol 131 (4) ◽

pp. 3348-3348

Author(s):

Michael Döllinger ◽

David A. Berry

Keyword(s):

Dynamical Behavior ◽

Vocal Folds ◽

False Vocal

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Changing Trends of Color of Different Laryngeal Regions in Laryngopharyngeal Reflux Disease

Ear Nose & Throat Journal ◽

10.1177/0145561319854745 ◽

2019 ◽

Vol 99 (8) ◽

pp. 543-547

Author(s):

Chen Du ◽

Paige Thayer ◽

Yan Yan ◽

Qingsong Liu ◽

Li Wang ◽

...

Keyword(s):

Laryngopharyngeal Reflux ◽

Ph Monitoring ◽

Vocal Folds ◽

Control Group ◽

Negative Group ◽

Positive Group ◽

Changing Trends ◽

Significant Difference ◽

False Vocal ◽

And Control

Introduction: In our previous study, we demonstrated that there might be correlations between laryngopharyngeal reflux disorder and the hue value of laryngoscopic images. And we found that different regions of larynx have different hue values. It was hypothesized that the degree of inflammation varies between different laryngeal regions, due to an acid reflux pattern. Objective: The objective of this study was to compare the changing trends of hue values of different laryngeal regions in patients with laryngopharyngeal reflux (LPR) disease. Methods: Ninety-seven patients, including 20 pH-positive, 19 pH-negative were tested for LPR through multichannel intraluminal impedance 24-hour pH monitoring, and 58 controls with reflux symptom index less than 13. Laryngoscopic images of all patients were obtained. The hue values of 7 areas of interest, including both sides of the true vocal folds, the false vocal folds, the arytenoids, and the interarytenoid space, were quantified using a hue calculation. The analysis of variance analysis was applied to find if there was significant difference between different groups within each region. Results: (1) In the regions of both sides of the true vocal folds and interarytenoid, there was no significant difference between positive group and negative group; (2) in the regions of both sides of false vocal folds, there was no significant difference between negative group and control group; (3) in the regions of both sides of arytenoids, there was neither significant difference between positive group and negative group nor between negative group and control group; (4) in other comparisons, there were significant differences. Conclusion: Hue values of separate laryngeal regions are different. In negative group, the hue values of interarytenoid region are similar with positive group, and the sensitivity to the acid are different from different regions. The sensitivity in the true vocal folds may be present.

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Laryngeal Thermal Injury Model

Journal of Burn Care & Research ◽

10.1093/jbcr/iraa009 ◽

2020 ◽

Vol 41 (3) ◽

pp. 626-632

Author(s):

Gregory R Dion ◽

Christian S Pingree ◽

Pedro J Rico ◽

Christine L Christensen

Keyword(s):

Wound Healing ◽

Thermal Injury ◽

Injury Severity ◽

Vocal Folds ◽

Burn Wound ◽

Burn Wound Healing ◽

Microscopic Evaluation ◽

Thermal Injuries ◽

False Vocal ◽

Over Time

Abstract A lack of reliable laryngeal thermal injury models precludes laryngeal burn wound healing studies and investigation of novel therapeutics. We hypothesize that a swine laryngeal burn model can allow for laryngeal burn evaluation over time. Twelve Yorkshire crossbreed swine underwent tracheostomy and endoscopically directed laryngeal burns using heated air (150–160°C). Swine larynges were evaluated and sectioned/stained at 12 hours, 1, 3, 7, 14, and 21 days. A board-certified veterinary pathologist assessed anatomic regions (left and right: epiglottis, true/false vocal folds, and subglottis) using a nine criteria histological injury scoring scale. Six swine were euthanized at scheduled endpoints, three prematurely (airway concerns), and three succumbed to airway complications after 16 to 36 hours. Endoscopic and gross examination from scheduled endpoints revealed massive supraglottic edema and tissue damage, particularly around the arytenoids, extending transglottically. Swine from premature endpoints had comparatively increased edema throughout. Microscopic evaluation documented an inverse relationship between injury severity score and time from injury. Inflammation severity decreased over time, nearly resolving by 14 days. Neutrophils predominated early with histiocytes appearing at 3 days. Granulation tissue appeared at 3 days, and early epiglottic and/or subglottic fibrosis appeared by 7 days and matured by 14 days. Edema, abundant initially, decreased by day 3 and resolved by day 7. This approach is the first to provide longitudinal analysis of laryngeal thermal injuries, reflecting some of the first temporal wound healing characteristic data in laryngeal thermal injuries and providing a platform for future therapeutic studies.

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