PT03.6: Resistance Exercise Induces Alterations in Whole Body Branched Chain Amino Acids (BCAA), Keto Acids (BCKA), and B-Hydroxy-B-Methylbutyrate (HMB) Metabolism in Patients with Chronic Obstructive Pulmonary Disease

Abstract Background Reversibility measured by spirometry in chronic obstructive pulmonary disease (COPD) is defined as an increase in forced expiratory volume in first second (FEV1) that is both more than 12% and 200 mL above the pre-bronchodilator value in response to inhaled bronchodilators. FEV1 only may not fully reverberate the changes caused by reduction in air trapping or hyperinflation. To date, the studies that examined the effect of inhaled bronchodilators (BD) on residual volume (RV) and total lung capacity (TLC) are limited. This study was carried out to assess the differences between flow and volume responses after bronchodilator reversibility testing in patients with different COPD GOLD stages (GOLD stage I to stage IV). Spirometry and whole body plethysmography were done before and 15 min after inhalation of 400 μg salbutamol. Results Majority (53.3%) of cases were volume responders, 18.7% were flow responders, 20% were flow and volume responders, and 8% were non responders. Significant increase in Δ FEV1% was found in 15% of cases while 55% showed a significant increase in Δ FVC (P= < 0.001). Mean difference of Δ FVC (L) post BD was significantly increased with advancing GOLD stage (P= 0.03). A cutoff point > 20% for Δ RV% had 70% sensitivity and 60% specificity and > 12% for Δ TLC% showed 90% sensitivity and 45% specificity for prediction of clinically significant response to BD based on FEV1. A cutoff point > 18% for Δ RV% had 78% sensitivity and 29% specificity and > 14% for Δ TLC% had 50% sensitivity and 70% specificity for prediction of clinically significant response to BD based on FVC. Conclusion ΔFEV1 underestimates the true effect of bronchodilators with advancing GOLD stage. Measurement of lung volumes in addition to the standard spirometric indices is recommended when determining bronchodilator response in COPD patients.

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Decreased Whole-Body and Splanchnic Glutamate Metabolism in Healthy Elderly Men and Patients with Chronic Obstructive Pulmonary Disease in the Postabsorptive State and in Response to Feeding

Journal of Nutrition ◽

10.1093/jn/135.9.2166 ◽

2005 ◽

Vol 135 (9) ◽

pp. 2166-2170 ◽

Cited By ~ 5

Author(s):

Erica P. A. Rutten ◽

Marielle P.K.J. Engelen ◽

Carmen L. N. Castro ◽

Emiel F. M. Wouters ◽

Annemie M.W.J. Schols ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Whole Body ◽

Chronic Obstructive ◽

Glutamate Metabolism ◽

Elderly Men ◽

Obstructive Pulmonary Disease ◽

Healthy Elderly

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Associations between Plasma Branched Chain Amino Acids and Health Biomarkers in Response to Resistance Exercise Training Across Age

Nutrients ◽

10.3390/nu12103029 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3029

Author(s):

Mariwan H. Sayda ◽

Bethan E. Phillips ◽

John P. Williams ◽

Paul L. Greenhaff ◽

Daniel J. Wilkinson ◽

...

Keyword(s):

Amino Acids ◽

Exercise Training ◽

Resistance Exercise ◽

Branched Chain Amino Acids ◽

Metabolic Health ◽

Whole Body ◽

Gas Chromatography Mass Spectrometry ◽

Resistance Exercise Training ◽

Fasting Plasma ◽

Branched Chain

Leucine, isoleucine and valine (i.e., the branched chain amino acids, BCAA) play a key role in the support of tissue protein regulation and can be mobilized as energy substrates during times of starvation. However, positive relationships exist between elevated levels of BCAA and insulin resistance (IR). Thus, we sought to investigate the links between fasting plasma BCAA following a progressive resistance exercise training (RET) programme, an intervention known to improve metabolic health. Fasting plasma BCAA were quantified in adults (young: 18–28 y, n = 8; middle-aged: 45–55 y, n = 9; older: 65–75 y, n = 15; BMI: 23–28 kg/m2, both males and females (~50:50), in a cross-sectional, intervention study. Participants underwent 20-weeks whole-body RET. Measurements of body composition, muscle strength (1-RM) and metabolic health biomarkers (e.g., HOMA-IR) were made at baseline and post-RET. BCAA concentrations were determined by gas-chromatography mass spectrometry (GC-MS). No associations were observed across age with BCAA; however, RET elicited (p < 0.05) increases in plasma BCAA (all age-groups), while HOMA-IR scores reduced (p < 0.05) following RET. After RET, positive correlations in lean body mass (p = 0.007) and strength gains (p = 0.001) with fasting BCAA levels were observed. Elevated BCAA are not a robust marker of ageing nor IR in those with a healthy BMI; rather, despite decreasing IR, RET was associated with increased BCAA.

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