P.7 The effect of a carnitine-palmitoyl-transferase-I-inhibitor(etomoxir) on hydrolysis and ketogenesis of medium-chain and long-chain triglycerides in perfused rat liver

1997 ◽  
Vol 16 ◽  
pp. 24
Author(s):  
A. Böer ◽  
B. Gebhardt ◽  
A. Sewell ◽  
H.-J. Böhles
Keyword(s):  
Rat Liver ◽  
Perfused Rat Liver ◽  
Carnitine Palmitoyl Transferase ◽  
Medium Chain ◽  
Carnitine Palmitoyl Transferase I ◽  
Long Chain Triglycerides ◽  
Long Chain

scholarly journals The effects of short term lipid infusion on plasma and hepatic bile lipids in humans

Gut ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 453-458 ◽  
Author(s):  
R Pakula ◽  
F M Konikoff ◽  
A M Moser ◽  
F Greif ◽  
A Tietz ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Lipid Emulsions ◽  
Medium Chain Triglycerides ◽  
Hepatic Bile ◽  
Lipid Infusion ◽  
Bile Composition ◽  
Medium Chain ◽  
Increased Risk ◽  
Long Chain Triglycerides ◽  
Long Chain

BACKGROUNDPatients on parenteral nutrition have an increased incidence of gall bladder sludge and gallstone disease, thought to be related to bile stasis. Intravenous lipid emulsions, especially those containing medium chain triglycerides, have also been shown to have a lithogenic effect on the composition of bile in the gall bladder.AIMSTo determine whether lipid infusion influences hepatic bile composition in patients with an indwelling T tube following cholecystectomy and choledochotomy.METHODSIn eight patients undergoing the above surgical procedure, the time at which effects of the interrupted enterohepatic circulation were minimal was determined. Twenty two cholesterol gallstone patients with bile fistula were then randomised to receive an infusion of a lipid emulsion containing either long chain triglycerides or a mixture of long and medium chain triglycerides.RESULTSLipid infusion resulted in a significant increase in plasma levels of triglycerides and phospholipids. Both lipid emulsions caused an increase in hepatic biliary cholesterol level and cholesterol saturation index, but this effect was more pronounced with medium chain triglycerides. The fatty acid composition of biliary phospholipids showed a significant enrichment of linoleic acid by both lipid infusions.CONCLUSIONSInfusion of triglycerides causes lithogenic changes in hepatic bile composition in humans, the lithogenic effect of infusion of medium chain triglycerides being more pronounced than that of long chain triglycerides. This effect, coupled with gall bladder stasis, may be responsible for the increased risk of biliary sludge and gallstone formation in patients on long term lipid infusion.

Effect of medium-chain triglycerides and long-chain triglycerides on plasma pancreatic polypeptide secretion in man

1985 ◽  
Vol 11 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Alphons J.L. de Jong ◽  
Wim P.M. Hopman ◽  
Jan B.M.J. Jansen ◽  
Cornelis B.H.W. Lamers
Keyword(s):  
Pancreatic Polypeptide ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Long Chain Triglycerides ◽  
Long Chain
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