Hepatitis B vaccine containing surface antigen and selected preS1 and preS2 sequences. 1. Safety and immunogenicity in young, healthy adults

Vaccine ◽  
1997 ◽  
Vol 15 (16) ◽  
pp. 1724-1731 ◽  
Author(s):  
Geert Leroux-Roels ◽  
Isabelle Desombere ◽  
Guido De Tollenaere ◽  
Marie-Anne Petit ◽  
Pierre Desmons ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Healthy Adults ◽  
Hepatitis B Vaccine

Hepatitis B Vaccine in Healthy Hospital Employees

1986 ◽  
Vol 7 (7) ◽  
pp. 365-369 ◽  
Author(s):  
S.A Klotz ◽  
R. Normand ◽  
R. Silberman
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Response Rate ◽  
Hepatitis B Surface Antigen ◽  
Hepatitis B Vaccine ◽  
Protective Level ◽  
Entire Series ◽  
Hospital Employees ◽  
Lower Response Rate ◽  
Low Rate

AbstractA low rate of seroconversion to hepatitis B vaccine is reported. This occurred in healthy hospital employees from two separate institutions. A total of 236 individuals were evaluated in this study and only 53% or 124 persons developed protective levels of antibody to hepatitis B surface antigen following a complete vaccine series. In one hospital, 30% of the vaccine recipients developed antibody but not to a protective level. Employees who received the entire series in the arm or in the arm and buttock (mixed) had a significantly greater number of responders than employees who received the entire series in the buttock (P<.05). Recipients aged 50 to 59 years had a significantly lower response rate to the vaccine (P<.05). There was no correlation with the vaccinee's sex or the timing of the second injection. Vaccine was noted to have frozen in one hospital and accounted for some loss of antigenicity. This failure to respond to the vaccine has necessitated the use of booster injections of vaccine and continued antibody monitoring.

scholarly journals Persistence of immunity in healthy adults aged ≥50 years primed with a hepatitis B vaccine 3 years previously

2015 ◽  
Vol 11 (7) ◽  
pp. 1709-1716 ◽  
Author(s):  
Rajiv Sharma ◽  
Clas Ahlm ◽  
Lars Ostergaard ◽  
Anthony Dowell ◽  
Clément Tran ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Healthy Adults ◽  
Hepatitis B Vaccine

scholarly journals Interference of Antibody Production to Hepatitis B Surface Antigen in a Combination Hepatitis A/Hepatitis B Vaccine

1999 ◽  
Vol 180 (6) ◽  
pp. 2018-2022 ◽  
Author(s):  
Sharon Frey ◽  
Ron Dagan ◽  
Yaffa Ashur ◽  
Xiao Q. Chen ◽  
Jose Ibarra ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Antibody Production ◽  
Hepatitis A ◽  
Hepatitis B Surface Antigen ◽  
Hepatitis B Vaccine

Safety and Immunogenicity of a Combined Hepatitis A and Hepatitis B Vaccine in Young Healthy Adults

1996 ◽  
Vol 31 (10) ◽  
pp. 1027-1031 ◽  
Author(s):  
G. Leroux-Roels ◽  
E. Moreau ◽  
I. Desombere ◽  
A. Safary
Keyword(s):  
Hepatitis B ◽  
Hepatitis A ◽  
Healthy Adults ◽  
Hepatitis B Vaccine

Hepatitis B vaccine boosting among young healthy adults

The Lancet ◽  
1995 ◽  
Vol 345 (8946) ◽  
pp. 395-396 ◽  
Author(s):  
Michael Gesemann ◽  
Norbert Scheiermann ◽  
WalterR. Gilks ◽  
S.Karen Vines ◽  
AntheaJ. Tilzey ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Healthy Adults ◽  
Hepatitis B Vaccine
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