Use of the Serum Creatinine to Estimate Glomerular Filtration Rate in Health and Early Diabetic Nephropathy

1990 ◽  
Vol 16 (3) ◽  
pp. 236-243 ◽  
Author(s):  
Jacob Lemann ◽  
Anil K. Bidani ◽  
Raymond P. Bain ◽  
Edmund J. Lewis ◽  
Richard D. Rohde
Keyword(s):  
Diabetic Nephropathy ◽  
Glomerular Filtration Rate ◽  
Serum Creatinine ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimate Glomerular Filtration Rate ◽  
Early Diabetic Nephropathy

scholarly journals Cystatin C Does Not Detect Acute Changes in Glomerular Filtration Rate in Early Diabetic Nephropathy

Renal Failure ◽  
2008 ◽  
Vol 30 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Thomas F. Mueller ◽  
Juliane Raeder ◽  
Karl Oettl ◽  
Sabine Zitta ◽  
Gert Klausmann ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Acute Changes ◽  
Early Diabetic Nephropathy

scholarly journals DIABETIC NEPHROPATHY;

2017 ◽  
Vol 24 (04) ◽  
pp. 554-559
Author(s):  
Muhammad Imran ◽  
Muhammad Usman Bashir ◽  
Ameena Nasir
Keyword(s):  
Uric Acid ◽  
Diabetic Nephropathy ◽  
Glomerular Filtration Rate ◽  
Serum Creatinine ◽  
Glomerular Filtration ◽  
Serum Uric Acid ◽  
Filtration Rate ◽  
Uric Acid Concentration ◽  
Creatinine Concentration ◽  
Serum Uric Acid Concentration

Objectives: To compare serum uric acid levels in different stages of diabeticnephropathy. Study Design: Descriptive analytical study. Setting: University of Health ScienceLahore. Period: February 2010 to January 2011. Subjects and methods: A sample size of195 diabetic subjects. They were divided among normoalbuminuric, microalbuminuric andmacroalbuminuric groups, according to their daily urinary albumin excretion rate (AER), with65 patients in each group. Their glomerular filtration rate (GFR), daily AER and serum uricacid was evaluated by conducting tests on serum and urine samples. Statistics: Kruskal-Wallis test and Mann-Whitney U test were used to observe differences of medians in differentgroups. P value less than 0.05 was taken statistically significant. Results: There was majority ofmales in microalbuminuric and macroalbuminuric groups while females were more in numberin normoalbuminuric group. Significant differences were found in serum urea concentration,serum creatinine concentration, serum uric acid concentration, glomerular filtration rate, urinarycreatinine concentration, urine flow rate, daily albumin excretion rate and urinary albuminconcentration among the three groups. Urinary creatinine concentration and glomerularfiltration rate were in the highest ranges in normoalbuminuric group and in the lowest rangesin macroalbuminuric group. While rest of the parameters (ie. age, duration of diabetes, serumurea concentration, serum creatinine concentration, urine flow rate, daily AER , urinary albuminconcentration and serum uric acid concentration) were in the lowest ranges in normoalbuminuricgroup and in the highest ranges in macroalbuminuric group. There was significant increaseserum uric acid levels in advancing stages of diabetic nephropathy. p <0.05 was takenstatistically significant. Conclusion: It is concluded that serum uric acid increases with theadvancing stages of diabetic nephropathy. Progressive decline in glomerular filtration rate andgradual rise in serum creatinine level occurs throughout the course of diabetic nephropathy.

scholarly journals Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy

2018 ◽  
Vol 314 (4) ◽  
pp. F531-F542 ◽  
Author(s):  
Masahiro Eriguchi ◽  
Mercury Lin ◽  
Michifumi Yamashita ◽  
Tuantuan V. Zhao ◽  
Zakir Khan ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Developed Countries ◽  
Tubular Injury ◽  
Wild Type ◽  
Tubulointerstitial Injury ◽  
Renal Tubular ◽  
Early Diabetic Nephropathy

Diabetic nephropathy is a major cause of end-stage renal disease in developed countries. While angiotensin-converting enzyme (ACE) inhibitors are used to treat diabetic nephropathy, how intrarenal ACE contributes to diabetic renal injury is uncertain. Here, two mouse models with different patterns of renal ACE expression were studied to determine the specific contribution of tubular vs. glomerular ACE to early diabetic nephropathy: it-ACE mice, which make endothelial ACE but lack ACE expression by renal tubular epithelium, and ACE 3/9 mice, which lack endothelial ACE and only express renal ACE in tubular epithelial cells. The absence of endothelial ACE normalized the glomerular filtration rate and endothelial injury in diabetic ACE 3/9 mice. However, these mice developed tubular injury and albuminuria and displayed low renal levels of megalin that were similar to those observed in diabetic wild-type mice. In diabetic it-ACE mice, despite hyperfiltration, the absence of renal tubular ACE greatly reduced tubulointerstitial injury and albuminuria and increased renal megalin expression compared with diabetic wild-type and diabetic ACE 3/9 mice. These findings demonstrate that endothelial ACE is a central regulator of the glomerular filtration rate while tubular ACE is a key player in the development of tubular injury and albuminuria. These data suggest that tubular injury, rather than hyperfiltration, is the main cause of microalbuminuria in early diabetic nephropathy.

scholarly journals Serum NGAL, BNP, PTH, and albumin do not improve glomerular filtration rate estimating formulas in children

2021 ◽  
Author(s):  
Julie Mouron-Hryciuk ◽  
François Cachat ◽  
Paloma Parvex ◽  
Thomas Perneger ◽  
Hassib Chehade
Keyword(s):  
Glomerular Filtration Rate ◽  
Parathyroid Hormone ◽  
Serum Creatinine ◽  
Brain Natriuretic Peptide ◽  
Glomerular Filtration ◽  
Natriuretic Peptide ◽  
Cystatin C ◽  
Filtration Rate ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

AbstractGlomerular filtration rate (GFR) is difficult to measure, and estimating formulas are notorious for lacking precision. This study aims to assess if the inclusion of additional biomarkers improves the performance of eGFR formulas. A hundred and sixteen children with renal diseases were enrolled. Data for age, weight, height, inulin clearance (iGFR), serum creatinine, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) were collected. These variables were added to the revised and combined (serum creatinine and cystatin C) Schwartz formulas, and the quadratic and combined quadratic formulas. We calculated the adjusted r-square (r2) in relation to iGFR and tested the improvement in variance explained by means of the likelihood ratio test. The combined Schwartz and the combined quadratic formulas yielded best results with an r2 of 0.676 and 0.730, respectively. The addition of BNP and PTH to the combined Schwartz and quadratic formulas improved the variance slightly. NGAL and albumin failed to improve the prediction of GFR further. These study results also confirm that the addition of cystatin C improves the performance of estimating GFR formulas, in particular the Schwartz formula.Conclusion: The addition of serum NGAL, BNP, PTH, and albumin to the combined Schwartz and quadratic formulas for estimating GFR did not improve GFR prediction in our population. What is Known:• Estimating glomerular filtration rate (GFR) formulas include serum creatinine and/or cystatin C but lack precision when compared to measured GFR.• The serum concentrations of some biological parameters such as neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) vary with the level of renal function. What is New:• The addition of BNP and PTH to the combined quadratic formula improved its performance only slightly. NGAL and albumin failed to improve the prediction of GFR further.

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