Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid

2003 ◽  
Vol 196 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Masao Yamasaki ◽  
Hitomi Chujo ◽  
Shinsuke Nou ◽  
Hirofumi Tachibana ◽  
Koji Yamada
Keyword(s):  
Linoleic Acid ◽  
Cytotoxic Activity ◽  
Conjugated Linoleic Acid ◽  
Palmitoleic Acid ◽  
Rat Hepatoma

Potent cytotoxic effect of the trans10, cis12 isomer of conjugated linoleic acid on rat hepatoma dRLh-84 cells

2002 ◽  
Vol 188 (1-2) ◽  
pp. 171-180 ◽  
Author(s):  
Masao Yamasaki ◽  
Hitomi Chujo ◽  
Yasuko Koga ◽  
Ayana Oishi ◽  
Tatsuya Rikimaru ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Cytotoxic Effect ◽  
Rat Hepatoma

Synthesis and evaluation of cytotoxic activity of conjugated linoleic acid derivatives (esters, alcohols, and their acetates) toward cancer cell lines

2017 ◽  
Vol 119 (10) ◽  
pp. 1600470 ◽  
Author(s):  
Natalia Niezgoda ◽  
Anna Gliszczyńska ◽  
Katarzyna Kempińska ◽  
Joanna Wietrzyk ◽  
Czesław Wawrzeńczyk
Keyword(s):  
Linoleic Acid ◽  
Cytotoxic Activity ◽  
Conjugated Linoleic Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines

Effect of Dietary Conjugated Linoleic Acid on the In Vivo Growth of Rat Hepatoma dRLh-84

2001 ◽  
Vol 40 (2) ◽  
pp. 140-148 ◽  
Author(s):  
Masao Yamasaki ◽  
Atsushi Ikeda ◽  
Akira Hirao ◽  
Yoko Tanaka ◽  
Yoshiyuki Miyazaki ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Dietary Conjugated Linoleic Acid ◽  
In Vivo Growth ◽  
Rat Hepatoma

scholarly journals Dose-Dependent Effect of Dietary Conjugated Linoleic Acid on the Growth of Rat Hepatoma dRLh-84 Cells In Vivo

2002 ◽  
Vol 48 (6) ◽  
pp. 505-511 ◽  
Author(s):  
Masao YAMASAKI ◽  
Atsushi IKEDA ◽  
Akira HIRAO ◽  
Yoko TANAKA ◽  
Tatsuya RIKIMARU ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Dependent Effect ◽  
Dietary Conjugated Linoleic Acid ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
Rat Hepatoma

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

Sign in / Sign up

Export Citation Format

Share Document