Effect of early thyroxine treatment on brain-derived neurotrophic factor mRNA expression and protein amount in the rat medial septum/diagonal band of Broca

2003 ◽  
Vol 350 (3) ◽  
pp. 141-144 ◽  
Author(s):  
Daniele Camboni ◽  
Thomas Roskoden ◽  
Herbert Schwegler
Keyword(s):  
Mrna Expression ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Medial Septum ◽  
Diagonal Band ◽  
Thyroxine Treatment ◽  
Diagonal Band Of Broca

No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial

2015 ◽  
Vol 28 (2) ◽  
pp. 101-109 ◽  
Author(s):  
Ulla Knorr ◽  
Pernille Koefoed ◽  
Mia H. Greisen Soendergaard ◽  
Maj Vinberg ◽  
Ulrik Gether ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Whole Blood ◽  
Neurotrophic Factor ◽  
Messenger Rna ◽  
Randomised Trial ◽  
Significant Negative Correlation ◽  
Brain Derived Neurotrophic Factor ◽  
Healthy Individuals ◽  
Bdnf Mrna ◽  
Significant Difference

ObjectiveBrain-derived neurotrophic factor (BDNF) seems to play an important role in the course of depression including the response to antidepressants in patients with depression. We aimed to study the effect of an antidepressant intervention on peripheral BDNF in healthy individuals with a family history of depression.MethodsWe measured changes in BDNF messenger RNA (mRNA) expression and whole-blood BDNF levels in 80 healthy first-degree relatives of patients with depression randomly allocated to receive daily tablets of escitalopram 10 mg versus placebo for 4 weeks.ResultsWe found no statistically significant difference between the escitalopram and the placebo group in the change in BDNF mRNA expression and whole-blood BDNF levels. Post hoc analyses showed a statistically significant negative correlation between plasma escitalopram concentration and change in whole-blood BDNF levels in the escitalopram-treated group.ConclusionThe results of this randomised trial suggest that escitalopram 10 mg has no effect on peripheral BDNF levels in healthy individuals.

scholarly journals Co-activation of nAChR and mGluR induces γ oscillation in rat medial septum diagonal band of Broca slices

2014 ◽  
Vol 35 (2) ◽  
pp. 175-184
Author(s):  
Ya-li Wang ◽  
Jian-gang Wang ◽  
Gao-xiang Ou-yang ◽  
Xiao-li Li ◽  
Zaineb Henderson ◽  
...  
Keyword(s):  
Medial Septum ◽  
Diagonal Band ◽  
Co Activation ◽  
Diagonal Band Of Broca
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