Tumour necrosis factor alpha induces only minor inflammatory changes in the central nervous system, but augments experimental meningitis

Neuroscience ◽  
1998 ◽  
Vol 86 (2) ◽  
pp. 627-634 ◽  
Author(s):  
K Angstwurm ◽  
D Freyer ◽  
U Dirnagl ◽  
U.K Hanisch ◽  
R.R Schumann ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Alpha ◽  
Necrosis Factor Alpha ◽  
The Central Nervous System ◽  
Factor Alpha ◽  
Inflammatory Changes ◽  
Necrosis Factor

scholarly journals Central Nervous System Demyelination Related to Tumour Necrosis Factor Alpha Inhibitor

2022 ◽  
Vol 8 (1) ◽  
pp. 205521732110707
Author(s):  
Shin Yee Chey ◽  
Allan G. Kermode
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Alpha ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Background An association between tumour necrosis factor alpha (TNF-α) inhibitors exposure and central nervous system (CNS) demyelinating disorders has been postulated but is poorly understood. Objectives Describe the clinical spectrum and progress of a cohort of patients who developed demyelinating disorder following exposure to TNF-α inhibitor. Methods Retrospective chart review of patients who presented to a single neurologist in Western Australia between May 2003 and July 2020. Results 7 patients (6 females and 1 male) were identified. Mean age was 49.1 years. Mean follow-up time was 2.9 years. Mean interval between commencement of TNF-α inhibitor and onset of demyelinating event was 3 years. The spectrum of demyelinating events included transverse myelitis ( N = 3), acute brainstem syndrome ( N = 1) and optic neuritis ( N = 1). 2 patients had an atypical presentation but had MRI findings which unequivocally showed demyelinating changes. 2 patients had a monophasic event while the other 5 patients were diagnosed to have multiple sclerosis. All symptomatic patients with multiple sclerosis were started on disease modifying therapy and remained relapse free during follow-up. Conclusion Exposure to TNF-α inhibitor appears to increase the risk of demyelinating event. Whether TNFα inhibition directly results in CNS demyelination or trigger demyelination in susceptible individuals requires further research.

Tumour necrosis factor-alpha polymorphism -308 G/a and its protein in subjects with gingivitis

2021 ◽  
pp. 1-6
Author(s):  
Julieta Sarai Becerra-Ruiz ◽  
Saúl Ramírez-De los Santos ◽  
Carmen Celina Alonso-Sánchez ◽  
Fernando Martínez-Esquivias ◽  
Luz Andrea Martínez-Pérez ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Alpha ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

M1259 Tumour Necrosis Factor-Alpha Expression in Segmental Colitis Associated With Diverticulosis is Related to the Severity of the Endoscopic Damage

2010 ◽  
Vol 138 (5) ◽  
pp. S-365 ◽  
Author(s):  
Antonio Tursi ◽  
Walter Elisei ◽  
Giovanni Brandimarte ◽  
GianMarco Giorgetti ◽  
Alfredo Papa ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Alpha ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Segmental Colitis
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