A new dicoumarinyl ether and two rare furocoumarins from Ruta montana

Fitoterapia ◽  
2003 ◽  
Vol 74 (1-2) ◽  
pp. 194-196 ◽  
Author(s):  
Z Kabouche ◽  
N Benkiki ◽  
E Seguin ◽  
C Bruneau
Keyword(s):  
Ruta Montana

Ruta montana evokes antihypertensive activity through increase of prosta-glandins release in L-NAME-induced hypertensive rats

2020 ◽  
Vol 20 ◽  
Author(s):  
El-Ouady Fadwa ◽  
Mohamed Eddouks
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Aqueous Extract ◽  
Antihypertensive Effect ◽  
Antihypertensive Activity ◽  
Computer Assisted ◽  
Hypertensive Rats ◽  
Vasorelaxant Effect ◽  
Vasorelaxant Activity ◽  
Ruta Montana

Aims: The aim of the study was to investigate experimentally the antihypertensive effect of Ruta Montana. Background: Ruta montana L. is traditionally used in Moroccan herbal medicine to treat hypertension. This study aimed to evaluate experimentally the hypotensive and vasoactive properties of this plant. Objective: The objective of the study was to evaluate the effect of the aqueous extract of Ruta Montana on blood pressure parameters in LNAME-induced hypertensive rats and to determine the vasorelaxant activity of this aqueous extract. Methods: The antihypertensive effect of the aqueous extract obtained from Ruta montana aerial parts (RMAPAE) (200 mg/kg) was evaluated in normal and anesthetized hypertensive rats. Blood pressure parameters (systolic blood pressure (SBP), mean blood pressure (MBP) and diastolic blood pressure (DBP)) and heart rate were measured using a tail-cuff and a computer-assisted monitoring device. The acute and chronic effect of RMAPAE was recorded during 6 hours for the acute experiment and during 7 days for the sub-chronic test. In the other set, the vasorelaxant effect of RMAPAE on the contractile response was undertaken in isolated thoracic aorta. Results: The results indicated that RMAPAE extract significantly decreased SBP, MBP, DBP and heart rate in L-NAMEinduced hypertensive rats. Furthermore, RMAPAE was demonstrated to induce a dose dependent relaxation in the aorta precontracted with Epinephrine or KCl. More interestingly, this vasorelaxant activity of RMAPAE seems to be probably mediated through the prostaglandins pathway. Conclusion: The present study illustrates the beneficial action of Ruta montana on hypertension and supports then its use as an antihypertensive agent.

Acute and chronic toxicity of aqueous extract of Ruta montana L. in rodents

2013 ◽  
Vol 3 (2) ◽  
pp. 50-57 ◽  
Author(s):  
Mounira Merghem ◽  
Saliha Dahamna ◽  
Abir Rezzagui ◽  
Soulef Boussahel ◽  
Assia Belguet ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Chronic Toxicity ◽  
Acute And Chronic Toxicity ◽  
Ruta Montana

scholarly journals In vitro digestion, antioxidant and antiacetylcholinesterase activities of two species of Ruta: Ruta chalepensis and Ruta montana

2016 ◽  
Vol 55 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Ayda Khadhri ◽  
Intidhar Bouali ◽  
Samia Belkhir ◽  
Rabhi Mokded ◽  
Samira Smiti ◽  
...  
Keyword(s):  
In Vitro Digestion ◽  
Ruta Chalepensis ◽  
Ruta Montana

Heraclenol and Isopimpinellin: Two Rare Furocoumarins from Ruta montana

Biodiversity ◽  
2002 ◽  
pp. 303-307 ◽  
Author(s):  
N. Benkiki ◽  
M. Benkhaled ◽  
Zahia Kabouche ◽  
C. Bruneau
Keyword(s):  
Ruta Montana

A propos d’un cas d’intoxication aigüe par Ruta montana

2015 ◽  
Vol 13 (1) ◽  
pp. 36-38 ◽  
Author(s):  
W. Masri ◽  
I. Belwaer ◽  
F. Khlifi ◽  
A. Nouioui ◽  
D. Ben salah ◽  
...  
Keyword(s):  
Ruta Montana

Erratum: A New Alkaloid, Montanine, from Ruta montana

1990 ◽  
Vol 53 (3) ◽  
pp. 685-685
Author(s):  
A Ulubelen
Keyword(s):  
Ruta Montana

Chemical Composition and Antioxidant Potential of Ruta montana L. Essential Oil from Algeria

2008 ◽  
Vol 11 (3) ◽  
pp. 593-595 ◽  
Author(s):  
N. Kambouche ◽  
B. Merah ◽  
S. Bellahouel ◽  
J. Bouayed ◽  
A. Dicko ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Antioxidant Potential ◽  
Ruta Montana

scholarly journals In-Vitro Antioxidant Activity and Total Phenolic Content of Ruta montana L. Extracts

2020 ◽  
Vol 10 (2) ◽  
pp. 69-75
Author(s):  
Mounira Merghem ◽  
Saliha Dahamna
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Chloroform Extract ◽  
Total Phenolic ◽  
Ruta Montana ◽  
Β Carotene

The aim of this study is to evaluate in vitro antioxidant activities of Ruta montana L.  extracts. This activity was evaluated by three methods : DPPH (2, 2'-diphenyl- 1- picrylhydrazy), bleaching of β-carotene and chelation of ferrous iron. Results showed that ethyl acetate extract (EAE) represents the highest amount of total polyphenols, tannins and flavonoids with 257,1 ± 0,703µg gallic acid equivalent/mg of extract,  251 ± 1.41 µg tannic acid equivalent /mg of extract,117,4 ± 3,451 µg quercetin equivalents/mg of extract, 139,5 ± 4,107 µg rutin equivalents/mg of extract, respectively. In the DPPH assay, ethyl acetate extract showed the higher scavenging capacity (IC50 = 0.044 ± 0.001 mg/ml) followed by methanol, aqueous and chloroform extract. Whereas, AqE showed the best chelating effect and the best inhibitory capacity of the coupled oxidation of linoleic acid/ β-carotene. Keywords: Ruta montana L; polyphenols; antioxidant activity; free radical scavenging.

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