Clinical utilities of single-photon biochemical tracers in estimating pathophysiologic processes in heart failure: 123I-BMIPP and 123I-MIBG

2002 ◽  
Vol 1228 ◽  
pp. 93-104
Author(s):  
Yoshio Ishida ◽  
Yoshio Yasumura ◽  
Tatsuya Sasaki ◽  
Kazuki Fukuchi ◽  
Hiroyuki Kakuchi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Single Photon ◽  
Biochemical Tracers

Nuclear cardiology: state of the art

Heart ◽  
2021 ◽  
pp. heartjnl-2019-315628
Author(s):  
Rebecca Schofield ◽  
Leon Menezes ◽  
Stephen Richard Underwood
Keyword(s):  
Heart Failure ◽  
Myocardial Perfusion ◽  
Radionuclide Imaging ◽  
Single Photon ◽  
Imaging Techniques ◽  
Sympathetic Innervation ◽  
Photon Emission ◽  
Myocardial Inflammation ◽  
Emission Computed Tomography ◽  
Device Infection

Radionuclide imaging remains an essential component of modern cardiology. There is overlap with the information from other imaging techniques, but no technique is static and new developments have expanded its role. This review focuses on ischaemic heart disease, heart failure, infection and inflammation. Radiopharmaceutical development includes the wider availability of positron emission tomography (PET) tracers such as rubidium-82, which allows myocardial perfusion to be quantified in absolute terms. Compared with alternative techniques, myocardial perfusion scintigraphy PET and single photon emission computed tomography (SPECT) have the advantages of being widely applicable using exercise or pharmacological stress, full coverage of the myocardium and a measure of ischaemic burden, which helps to triage patients between medical therapy and revascularisation. Disadvantages include the availability of expertise in some cardiac centres and the lack of simple SPECT quantification, meaning that global abnormalities can be underestimated. In patients with heart failure, despite the findings of the STICH (Surgical Treatment for Ischemic Heart Failure) trial, there are still data to support the assessment of myocardial hibernation in predicting when abolition of ischaemia might lead to improvement in ventricular function. Imaging of sympathetic innervation is well validated, but simpler markers of prognosis mean that it has not been widely adopted. There are insufficient data to support its use in predicting the need for implanted devices, but non-randomised studies are promising. Other areas where radionuclide imaging is uniquely valuable are detection and monitoring of endocarditis, device infection, myocardial inflammation in sarcoidosis, myocarditis and so on, and reliable detection of deposition in suspected transthyretin-related amyloidosis.

scholarly journals Possibilities of Evaluating the Dynamics of Left Ventricular Perfusion and Contractility in Patients with Chronic Heart Failure after Implantation of a Heart Contractility Modulator Using Perfusion Single-Photon Emission Computed Tomography

2021 ◽  
Vol 17 (2) ◽  
pp. 263-269
Author(s):  
V. A. Amanatova ◽  
A. A. Safiullina ◽  
T. M. Uskach ◽  
A. A. Ansheles ◽  
V. B. Sergienko ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Nuclear Cardiology ◽  
Single Photon ◽  
Photon Emission ◽  
Cardiac Contractility ◽  
Left Ventricular ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Heart Contractility

Perfusion scintigraphy and single-photon emission tomography of the myocardium are promising methods for complex assessment of the state of the left ventricle myocardium in patients with chronic heart failure. These methods of nuclear cardiology can be performed in patients with reduced renal function, as well as the presence of implanted devices such as implantable cardioverters-defibrillators, resynchronizing devices and cardiac modulating therapy, which is their undeniable advantage. The reproducibility of the method is ensured bu fully automated calculation of parameters of myocardial perfusion and contractility. To date, there are no data in the literature on the use of nuclear cardiology methods as an imaging technique in patients with cardiac contractility modulation devises. This paper describes the current possibilities and prospects of nuclear medicine methods in patients with chronic heart failure after implantation of a heart contractility modulator.

Prognostic value of cardiac iodine-123 metaiodobenzylguanidine imaging in patients with indications for cardiac resynchronization therapy

2014 ◽  
Vol 21 (2) ◽  
pp. 81-90
Author(s):  
Vytė Valerija Maneikienė ◽  
Donatas Vajauskas ◽  
Audrius Aidietis ◽  
Algirdas Edvardas Tamošiūnas ◽  
Kęstutis Ručinskas ◽  
...  
Keyword(s):  
Heart Failure ◽  
Single Photon ◽  
Clinical Status ◽  
Photon Emission ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Left Ventricular Ejection ◽  
Emission Computed Tomography ◽  
Mibg Imaging ◽  
Ventricular Ejection Fraction

Background. The aim of our study was to assess the cardiac 123I-MIBG imaging predictive value on the clinical outcome in HF patients with wide QRS complexes and compare its power in different treatment groups. Materials and methods. We have prospectively investigated 67 heart failure patients with the New York Heart Association (NYHA) functional class II–IV, wide QRS complexes (>120 milliseconds), reduced left ventricular ejection fraction (LV EF) eligible for CRT. 123I-MIBG planar and single photon emission computed tomography (SPECT) scans were performed in a supine position with calculation of early and late heart-to-mediastinum (H/M) ratios, washout ratio (WR), summed defect scores and scores difference from SPECT acquisition. All patients were then divided in two groups according to their clinical status – 36 patients underwent implantation of CRT, and 31 patients were continued with OMT. Initial conventional heart failure markers and NYHA were assessed at the time of 123I-MIBG imaging and 6 months later. Comparisons of two groups were done applying the Student’s t-test, and if samples were small, the Fisher’s exact test was used. NYHA groups were compared applying the ANOVA single factor analysis. ROC curve analysis was performed to establish cut off values for predictors of response. Results. Cardiac 123I-MIBG imaging data differed insignificantly, presenting a similar cardiac adrenergic innervation status in both groups. In the CRT group, NYHA and LV EF indicated more pronounced signs of HF. For all patients, NYHA IV patients had significantly larger LV diameter, smaller EF, larger BNP levels, lower late H/M values and larger denervation score difference. Responders to therapy (both groups) had significantly higher early H/M ratio  –  2.35  ±  0.41 than non-responders  –  2.00  ±  0.44 (p  =  0.004), and late H/M ratio  –  2.11  ±  0.44 for responders and 1.72 ± 0.54 for non-responders (p = 0.005). There were no significant differences in regional cardiac 123I-MIBG data for responders and non-responders. Conclusions. Cardiac 123I-MIBG imaging has valuable prognostic power predicting clinical outcomes of HF patients with wide QRS complexes, despite the chosen type of treatment, with better outcomes for patients with early H/M ratio 2.00 and late H/M ratio above 1.77.

scholarly journals Rapid Fire Abstract session: usefulness of CT and radionuclide imaging in different clinical scenarios378Improving the cost-effectiveness of chest pain investigations using single photon emission computed tomography379Is autonomic nervous dysfunction severity associated to less benefit from cardiac resynchronization therapy?380Validation of stress Thallium-201/Rest Technetium-99m sequential dual isotope high-speed myocardial perfusion imaging against fractional flow reserve for the detection of the extent of ischemia.381Nuclear imaging to predict adverse events in heart failure patients382Autonomic nervous system modulation in patients with heart failure and resynchronization after high intensity interval training383Long-term prediction of cardiac events using low-dose coronary ct angiography with prospective triggering384Left atrial appendage sizing for percutaneous occlusion with Amplatzer cardiac plug: a multimodality imaging approach385Evaluation of PAPVR using cardiac CT or MR imaging in patients with Turner syndrome.

2015 ◽  
Vol 16 (suppl 2) ◽  
pp. S48-S50 ◽  
Author(s):  
J Lagan ◽  
P Rio ◽  
G Barone-Rochette ◽  
J Limeres Freire ◽  
A Abreu ◽  
...  
Keyword(s):  
Heart Failure ◽  
High Speed ◽  
Single Photon ◽  
Multimodality Imaging ◽  
Photon Emission ◽  
Cardiac Resynchronization ◽  
Cardiac Events ◽  
Fractional Flow ◽  
Dual Isotope ◽  
Flow Reserve
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