VARIATION IN INTRACORONARY LIPID-RICH PLAQUE DETECTED BY NEAR-INFRARED SPECTROSCOPY IN ASYMPTOMATIC INDIVIDUALS WITH HIGH CORONARY ARTERY CALCIUM SCORES

Since there is merit in noninvasive monitoring of muscular oxidative metabolism for near-infrared spectroscopy in a wide range of clinical scenarios, the present study attempted to evaluate the clinical usability for featuring the modulatory strategies of sternocleidomastoid muscular oxygenation using near-infrared spectroscopy in mild nonspecific neck pain patients. The muscular oxygenation variables of the dominant or affected sternocleidomastoid muscles of interest were extracted at 25% of the maximum voluntary isometric contraction from ten patients (5 males and 5 females, 23.6 ± 4.2 years) and asymptomatic individuals (6 males and 4 females, 24.0 ± 5.1 years) using near-infrared spectroscopy. Only a shorter half-deoxygenation time of oxygen saturation during a sternocleidomastoid isometric contraction was noted in patients compared to asymptomatic individuals (10.43 ± 1.79 s vs. 13.82 ± 1.42 s, p < 0.001). Even though the lack of statically significant differences in most of the muscular oxygenation variables failed to refine the definite pathogenic mechanisms underlying nonspecific neck pain, the findings of modulatory strategies of faster deoxygenation implied that near-infrared spectroscopy appears to have practical potential to provide relevant physiological information regarding muscular oxidative metabolism and constituted convincing preliminary evidences of the adaptive manipulations rather than pathological responses of oxidative metabolism capacity of sternocleidomastoid muscles in nonspecific neck patients with mild disability.

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Application of Peripheral Near Infrared Spectroscopy to Assess Risk Factors in Patient with Coronary Artery Disease: Part 2

Advances in Experimental Medicine and Biology - Oxygen Transport to Tissue XLI ◽

10.1007/978-3-030-34461-0_45 ◽

2020 ◽

pp. 355-360

Author(s):

Keiichiro Kuronuma ◽

Tsuyoshi Kawamorita ◽

Tsukasa Yagi ◽

Eizo Tachibana ◽

Shonosuke Sugai ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Infrared Spectroscopy ◽

Coronary Artery ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Artery Disease

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Relation of Plasma Xanthine Oxidoreductase Activity to Coronary Lipid Core Plaques Assessed by Near-Infrared Spectroscopy Intravascular Ultrasound in Patients With Stable Coronary Artery Disease

The American Journal of Cardiology ◽

10.1016/j.amjcard.2019.12.043 ◽

2020 ◽

Vol 125 (7) ◽

pp. 1006-1012 ◽

Cited By ~ 3

Author(s):

Naoto Mori ◽

Yuichi Saito ◽

Kan Saito ◽

Takaaki Matsuoka ◽

Kazuya Tateishi ◽

...

Keyword(s):

Coronary Artery Disease ◽

Infrared Spectroscopy ◽

Coronary Artery ◽

Intravascular Ultrasound ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Stable Coronary Artery Disease ◽

Xanthine Oxidoreductase ◽

Oxidoreductase Activity ◽

Artery Disease

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CRT-300.02 Longitudinal Distribution of Lipid-rich Plaque Components in Culprit Lesions: A Near-infrared Spectroscopy Study

JACC Cardiovascular Interventions ◽

10.1016/j.jcin.2018.01.116 ◽

2018 ◽

Vol 11 (4) ◽

pp. S36

Author(s):

Hideaki Ota ◽

Shuichi Okamoto ◽

Toru Tanigaki ◽

Hiroyuki Omori ◽

Tetsuo Hirata ◽

...

Keyword(s):

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Longitudinal Distribution ◽

Spectroscopy Study ◽

Lipid Rich Plaque

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Intracoronary near-infrared spectroscopy and the risk of future cardiovascular events

Open Heart ◽

10.1136/openhrt-2018-000917 ◽

2019 ◽

Vol 6 (1) ◽

pp. e000917 ◽

Cited By ~ 7

Author(s):

Sofia Karlsson ◽

Erik Anesäter ◽

Klara Fransson ◽

Pontus Andell ◽

Jonas Persson ◽

...

Keyword(s):

Coronary Artery Disease ◽

Infrared Spectroscopy ◽

Coronary Artery ◽

Near Infrared Spectroscopy ◽

Cardiovascular Events ◽

Roc Analysis ◽

Near Infrared ◽

Plaque Burden ◽

Cerebrovascular Events ◽

Artery Disease

ObjectivesThe objectives of this study were to investigate if findings by intracoronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) are associated with future cardiovascular events and if NIRS can differentiate culprit from non-culprit segments in patients with coronary artery disease.MethodsThe study included 144 patients with coronary artery disease undergoing percutaneous coronary intervention and combined NIRS-IVUS imaging at two Swedish hospitals. The NIRS-derived lipid core burden index (LCBI), the 4 mm segment with maximum LCBI (MaxLCBI4mm) and the IVUS-derived maximum plaque burden (MaxPB) were analysed within the culprit segment and continuous 10 mm non-culprit segments of the index culprit vessels. The association with future major adverse cardiovascular and cerebrovascular events (MACCE), defined as all-cause mortality, acute coronary syndrome requiring revascularisation and cerebrovascular events during follow-up was evaluated using multivariable Cox regressions. A receiver operating characteristic (ROC) analysis was performed to test the ability of NIRS to discriminate culprit against non-culprit segments.ResultsA non-culprit maxLCBI4mm ≥400 (HR: 3.67, 95% CI 1.46 to 9.23, p=0.006) and a non-culprit LCBI ≥ median (HR: 3.08, 95% CI 1.11 to 8.56, p=0.031) were both significantly associated with MACCE, whereas a non-culprit MaxPB ≥70% (HR: 0.61, 95% CI 0.08 to 4.59, p=0.63) was not. The culprit segments had larger lipid cores compared with non-culprit segments (MaxLCBI4mm 425 vs 74, p<0.001), and the ROC analysis showed that NIRS can differentiate culprit against non-culprit segments (c-statistics: 0.85, 95% CI 0.81 to 0.89).ConclusionA maxLCBI4mm ≥400 and LCBI ≥ median, assessed by NIRS in non-culprit segments of a culprit artery, were significantly associated with patient-level MACCE. NIRS furthermore adequately discriminated culprit against non-culprit segments in patients with coronary disease.

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